Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets

Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets

A longitudinal analysis of SARS-CoV-2 infection in humans is challenging. Here the authors show a single cell RNA-sequencing analysis of BAL fluid cells from ferrets and characterise the time dependent recruitment of macrophage subsets to the lungs in response to SARS-CoV-2 infection.

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Autores principales: Jeong Seok Lee, June-Young Koh, Kijong Yi, Young-Il Kim, Su-Jin Park, Eun-Ha Kim, Se-Mi Kim, Sung Ho Park, Young Seok Ju, Young Ki Choi, Su-Hyung Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3fcb349eb9d2404d912ec95de1112f28
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spelling oai:doaj.org-article:3fcb349eb9d2404d912ec95de1112f282021-12-02T16:23:44ZSingle-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets10.1038/s41467-021-24807-02041-1723https://doaj.org/article/3fcb349eb9d2404d912ec95de1112f282021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24807-0https://doaj.org/toc/2041-1723A longitudinal analysis of SARS-CoV-2 infection in humans is challenging. Here the authors show a single cell RNA-sequencing analysis of BAL fluid cells from ferrets and characterise the time dependent recruitment of macrophage subsets to the lungs in response to SARS-CoV-2 infection.Jeong Seok LeeJune-Young KohKijong YiYoung-Il KimSu-Jin ParkEun-Ha KimSe-Mi KimSung Ho ParkYoung Seok JuYoung Ki ChoiSu-Hyung ParkNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jeong Seok Lee
June-Young Koh
Kijong Yi
Young-Il Kim
Su-Jin Park
Eun-Ha Kim
Se-Mi Kim
Sung Ho Park
Young Seok Ju
Young Ki Choi
Su-Hyung Park
Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets
description A longitudinal analysis of SARS-CoV-2 infection in humans is challenging. Here the authors show a single cell RNA-sequencing analysis of BAL fluid cells from ferrets and characterise the time dependent recruitment of macrophage subsets to the lungs in response to SARS-CoV-2 infection.
format article
author Jeong Seok Lee
June-Young Koh
Kijong Yi
Young-Il Kim
Su-Jin Park
Eun-Ha Kim
Se-Mi Kim
Sung Ho Park
Young Seok Ju
Young Ki Choi
Su-Hyung Park
author_facet Jeong Seok Lee
June-Young Koh
Kijong Yi
Young-Il Kim
Su-Jin Park
Eun-Ha Kim
Se-Mi Kim
Sung Ho Park
Young Seok Ju
Young Ki Choi
Su-Hyung Park
author_sort Jeong Seok Lee
title Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets
title_short Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets
title_full Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets
title_fullStr Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets
title_full_unstemmed Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets
title_sort single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during sars-cov-2 infection in ferrets
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/3fcb349eb9d2404d912ec95de1112f28
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