Simulation of pH-Dependent Conformational Transitions in Membrane Proteins: The CLC-ec1 Cl<sup>−</sup>/H<sup>+</sup> Antiporter

Intracellular transport of chloride by members of the CLC transporter family involves a coupled exchange between a Cl<sup>−</sup> anion and a proton (H<sup>+</sup>), which makes the transport function dependent on ambient pH. Transport activity peaks at pH 4.5 and stalls at n...

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Autores principales: Ekaterina Kots, Derek M. Shore, Harel Weinstein
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/3fcb8aab014141448b78da10c6219dc3
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