Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma

Despite extensive genetic heterogeneity, nearly half of all multiple myeloma (MM) cases are driven by cyclin D2 (CCND2) over-expression. Here the authors dissect the chromatin landscape of MM to provide insights into the transcriptional regulatory landscape driving MM and divergent transcriptomes co...

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Autores principales:	Jaime Alvarez-Benayas, Nikolaos Trasanidis, Alexia Katsarou, Kanagaraju Ponnusamy, Aristeidis Chaidos, Philippa C. May, Xiaolin Xiao, Marco Bua, Maria Atta, Irene A. G. Roberts, Holger W. Auner, Evdoxia Hatjiharissi, Maria Papaioannou, Valentina S. Caputo, Ian M. Sudbery, Anastasios Karadimitris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3fcdca45e3ee4529b529898c605a8394
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spelling	oai:doaj.org-article:3fcdca45e3ee4529b529898c605a83942021-12-02T15:15:41ZChromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma10.1038/s41467-021-25704-22041-1723https://doaj.org/article/3fcdca45e3ee4529b529898c605a83942021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25704-2https://doaj.org/toc/2041-1723Despite extensive genetic heterogeneity, nearly half of all multiple myeloma (MM) cases are driven by cyclin D2 (CCND2) over-expression. Here the authors dissect the chromatin landscape of MM to provide insights into the transcriptional regulatory landscape driving MM and divergent transcriptomes corresponding to different MM genetic subtypes.Jaime Alvarez-BenayasNikolaos TrasanidisAlexia KatsarouKanagaraju PonnusamyAristeidis ChaidosPhilippa C. MayXiaolin XiaoMarco BuaMaria AttaIrene A. G. RobertsHolger W. AunerEvdoxia HatjiharissiMaria PapaioannouValentina S. CaputoIan M. SudberyAnastasios KaradimitrisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jaime Alvarez-Benayas Nikolaos Trasanidis Alexia Katsarou Kanagaraju Ponnusamy Aristeidis Chaidos Philippa C. May Xiaolin Xiao Marco Bua Maria Atta Irene A. G. Roberts Holger W. Auner Evdoxia Hatjiharissi Maria Papaioannou Valentina S. Caputo Ian M. Sudbery Anastasios Karadimitris Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
description	Despite extensive genetic heterogeneity, nearly half of all multiple myeloma (MM) cases are driven by cyclin D2 (CCND2) over-expression. Here the authors dissect the chromatin landscape of MM to provide insights into the transcriptional regulatory landscape driving MM and divergent transcriptomes corresponding to different MM genetic subtypes.
format	article
author	Jaime Alvarez-Benayas Nikolaos Trasanidis Alexia Katsarou Kanagaraju Ponnusamy Aristeidis Chaidos Philippa C. May Xiaolin Xiao Marco Bua Maria Atta Irene A. G. Roberts Holger W. Auner Evdoxia Hatjiharissi Maria Papaioannou Valentina S. Caputo Ian M. Sudbery Anastasios Karadimitris
author_facet	Jaime Alvarez-Benayas Nikolaos Trasanidis Alexia Katsarou Kanagaraju Ponnusamy Aristeidis Chaidos Philippa C. May Xiaolin Xiao Marco Bua Maria Atta Irene A. G. Roberts Holger W. Auner Evdoxia Hatjiharissi Maria Papaioannou Valentina S. Caputo Ian M. Sudbery Anastasios Karadimitris
author_sort	Jaime Alvarez-Benayas
title	Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
title_short	Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
title_full	Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
title_fullStr	Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
title_full_unstemmed	Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
title_sort	chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3fcdca45e3ee4529b529898c605a8394
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Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma

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