Epithelial Aryl Hydrocarbon Receptor Protects From Mucus Production by Inhibiting ROS-Triggered NLRP3 Inflammasome in Asthma

BackgroundDespite long-standing recognition in the significance of mucus overproduction in asthma, its etiology remains poorly understood. Muc5ac is a secretory mucin that has been associated with reduced pulmonary function and asthma exacerbations.ObjectivesWe sought to investigate the immunologica...

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Autores principales: Xinyue Hu, Yingchun Shen, Yilin Zhao, Ji Wang, Xin Zhang, Wei Tu, William Kaufman, Juntao Feng, Peisong Gao
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
ROS
Acceso en línea:https://doaj.org/article/3fd14cf87caf4b32bf86593efa1e708d
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