Characteristics of gut microbiota in people with obesity.

<h4>Background</h4>Obesity is the cause of cardiovascular diseases and other diseases, leading to increased medical costs, and causing a great burden to individuals, families and society. The prevalence of obesity is increasing and has become a global health problem. There is growing evi...

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Autores principales:	Mengmeng Duan, Yuezhu Wang, Qiang Zhang, Rong Zou, Min Guo, Huajun Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3fd25d4681d548729719af0ae8742301
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spelling	oai:doaj.org-article:3fd25d4681d548729719af0ae87423012021-12-02T20:18:27ZCharacteristics of gut microbiota in people with obesity.1932-620310.1371/journal.pone.0255446https://doaj.org/article/3fd25d4681d548729719af0ae87423012021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255446https://doaj.org/toc/1932-6203<h4>Background</h4>Obesity is the cause of cardiovascular diseases and other diseases, leading to increased medical costs, and causing a great burden to individuals, families and society. The prevalence of obesity is increasing and has become a global health problem. There is growing evidence that gut microbiota plays an important role in obesity. In this article, we revealed the differences in the gut microbiota between 21 people with obesity and 21 control subjects, and predicted the functional potential changes by 16S rRNA sequencing of the fecal bacteria of the subjects.<h4>Methods</h4>The raw sequencing data of 21 healthy Beijing volunteers was downloaded from Microbial Genome Database System. Microbial 16S rRNA genes of 21 adults with obesity were sequenced on an Illumina MiSeq instrument and analyzed by using bioinformatics and statistical methods.<h4>Results</h4>The diversity of gut microbiota in people with obesity decreased significantly. There were significant differences in gut microbiota between the Obesity and Control group at different levels. At the phylum level, Firmicutes, Bacteroidetes, Actinobacteria and Fusobacteria are significantly different between the Obesity and Control group. In people with obesity, the ratio of Firmicutes/Bacteroidetes decreased significantly. At the genus level, there were significant differences among the 16 major genera, of which four genera Prevotella, Megamonas, Fusobacterium and Blautia increased significantly in people with obesity, while the remaining 12 genera, Faecalibacterium, Lachnospiracea_incertae_sedis, Gemmiger and Clostridium XlVa, etc. decreased significantly. At the species level, nine species including Bacteroides uniformis and Prevotella copri had significant differences. Compared with the control group, subjects with obesity were abnormalities in 57 pathways, mainly in Carbohydrate metabolism and Lipid metabolism.<h4>Conclusions</h4>Overall, our study revealed differences in the gut microbiota between people with obesity and control subjects, providing novel target for the treatment of individuals with obesity.Mengmeng DuanYuezhu WangQiang ZhangRong ZouMin GuoHuajun ZhengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255446 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mengmeng Duan Yuezhu Wang Qiang Zhang Rong Zou Min Guo Huajun Zheng Characteristics of gut microbiota in people with obesity.
description	<h4>Background</h4>Obesity is the cause of cardiovascular diseases and other diseases, leading to increased medical costs, and causing a great burden to individuals, families and society. The prevalence of obesity is increasing and has become a global health problem. There is growing evidence that gut microbiota plays an important role in obesity. In this article, we revealed the differences in the gut microbiota between 21 people with obesity and 21 control subjects, and predicted the functional potential changes by 16S rRNA sequencing of the fecal bacteria of the subjects.<h4>Methods</h4>The raw sequencing data of 21 healthy Beijing volunteers was downloaded from Microbial Genome Database System. Microbial 16S rRNA genes of 21 adults with obesity were sequenced on an Illumina MiSeq instrument and analyzed by using bioinformatics and statistical methods.<h4>Results</h4>The diversity of gut microbiota in people with obesity decreased significantly. There were significant differences in gut microbiota between the Obesity and Control group at different levels. At the phylum level, Firmicutes, Bacteroidetes, Actinobacteria and Fusobacteria are significantly different between the Obesity and Control group. In people with obesity, the ratio of Firmicutes/Bacteroidetes decreased significantly. At the genus level, there were significant differences among the 16 major genera, of which four genera Prevotella, Megamonas, Fusobacterium and Blautia increased significantly in people with obesity, while the remaining 12 genera, Faecalibacterium, Lachnospiracea_incertae_sedis, Gemmiger and Clostridium XlVa, etc. decreased significantly. At the species level, nine species including Bacteroides uniformis and Prevotella copri had significant differences. Compared with the control group, subjects with obesity were abnormalities in 57 pathways, mainly in Carbohydrate metabolism and Lipid metabolism.<h4>Conclusions</h4>Overall, our study revealed differences in the gut microbiota between people with obesity and control subjects, providing novel target for the treatment of individuals with obesity.
format	article
author	Mengmeng Duan Yuezhu Wang Qiang Zhang Rong Zou Min Guo Huajun Zheng
author_facet	Mengmeng Duan Yuezhu Wang Qiang Zhang Rong Zou Min Guo Huajun Zheng
author_sort	Mengmeng Duan
title	Characteristics of gut microbiota in people with obesity.
title_short	Characteristics of gut microbiota in people with obesity.
title_full	Characteristics of gut microbiota in people with obesity.
title_fullStr	Characteristics of gut microbiota in people with obesity.
title_full_unstemmed	Characteristics of gut microbiota in people with obesity.
title_sort	characteristics of gut microbiota in people with obesity.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3fd25d4681d548729719af0ae8742301
work_keys_str_mv	AT mengmengduan characteristicsofgutmicrobiotainpeoplewithobesity AT yuezhuwang characteristicsofgutmicrobiotainpeoplewithobesity AT qiangzhang characteristicsofgutmicrobiotainpeoplewithobesity AT rongzou characteristicsofgutmicrobiotainpeoplewithobesity AT minguo characteristicsofgutmicrobiotainpeoplewithobesity AT huajunzheng characteristicsofgutmicrobiotainpeoplewithobesity
_version_	1718374279313096704

Characteristics of gut microbiota in people with obesity.

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