Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

Tobacco use is one of the major risk factors for Head and neck squamous cell carcinoma (HNSCC). Here, the authors report an immune-competent syngeneic mouse model that mimics human tobacco-related HNSCC, and develops tumors in the tongue, and report a high response rate to anti-CTLA-4 therapy.

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Autores principales:	Zhiyong Wang, Victoria H. Wu, Michael M. Allevato, Mara Gilardi, Yudou He, Juan Luis Callejas-Valera, Lynn Vitale-Cross, Daniel Martin, Panomwat Amornphimoltham, James Mcdermott, Bryan S. Yung, Yusuke Goto, Alfredo A. Molinolo, Andrew B. Sharabi, Ezra E. W. Cohen, Qianming Chen, J. Guy Lyons, Ludmil B. Alexandrov, J. Silvio Gutkind
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3fd2a00b6d274d9893b38fa9d6f2e131
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spelling	oai:doaj.org-article:3fd2a00b6d274d9893b38fa9d6f2e1312021-12-02T16:57:50ZSyngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-410.1038/s41467-019-13471-02041-1723https://doaj.org/article/3fd2a00b6d274d9893b38fa9d6f2e1312019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13471-0https://doaj.org/toc/2041-1723Tobacco use is one of the major risk factors for Head and neck squamous cell carcinoma (HNSCC). Here, the authors report an immune-competent syngeneic mouse model that mimics human tobacco-related HNSCC, and develops tumors in the tongue, and report a high response rate to anti-CTLA-4 therapy.Zhiyong WangVictoria H. WuMichael M. AllevatoMara GilardiYudou HeJuan Luis Callejas-ValeraLynn Vitale-CrossDaniel MartinPanomwat AmornphimolthamJames McdermottBryan S. YungYusuke GotoAlfredo A. MolinoloAndrew B. SharabiEzra E. W. CohenQianming ChenJ. Guy LyonsLudmil B. AlexandrovJ. Silvio GutkindNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhiyong Wang Victoria H. Wu Michael M. Allevato Mara Gilardi Yudou He Juan Luis Callejas-Valera Lynn Vitale-Cross Daniel Martin Panomwat Amornphimoltham James Mcdermott Bryan S. Yung Yusuke Goto Alfredo A. Molinolo Andrew B. Sharabi Ezra E. W. Cohen Qianming Chen J. Guy Lyons Ludmil B. Alexandrov J. Silvio Gutkind Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
description	Tobacco use is one of the major risk factors for Head and neck squamous cell carcinoma (HNSCC). Here, the authors report an immune-competent syngeneic mouse model that mimics human tobacco-related HNSCC, and develops tumors in the tongue, and report a high response rate to anti-CTLA-4 therapy.
format	article
author	Zhiyong Wang Victoria H. Wu Michael M. Allevato Mara Gilardi Yudou He Juan Luis Callejas-Valera Lynn Vitale-Cross Daniel Martin Panomwat Amornphimoltham James Mcdermott Bryan S. Yung Yusuke Goto Alfredo A. Molinolo Andrew B. Sharabi Ezra E. W. Cohen Qianming Chen J. Guy Lyons Ludmil B. Alexandrov J. Silvio Gutkind
author_facet	Zhiyong Wang Victoria H. Wu Michael M. Allevato Mara Gilardi Yudou He Juan Luis Callejas-Valera Lynn Vitale-Cross Daniel Martin Panomwat Amornphimoltham James Mcdermott Bryan S. Yung Yusuke Goto Alfredo A. Molinolo Andrew B. Sharabi Ezra E. W. Cohen Qianming Chen J. Guy Lyons Ludmil B. Alexandrov J. Silvio Gutkind
author_sort	Zhiyong Wang
title	Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
title_short	Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
title_full	Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
title_fullStr	Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
title_full_unstemmed	Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
title_sort	syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-ctla-4
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3fd2a00b6d274d9893b38fa9d6f2e131
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Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

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