Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice.

Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice.

Obesity/metabolic syndrome are common risk factors for overactive bladder. This study aimed to investigate the functional and molecular changes of detrusor smooth muscle (DSM) in high-fat insulin resistant obese mice, focusing on the role of protein kinase C (PKC) and Ca(v)1.2 in causing bladder dys...

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Autores principales: Luiz O Leiria, Carolina Sollon, Marina C Calixto, Letícia Lintomen, Fabíola Z Mónica, Gabriel F Anhê, Gilberto De Nucci, Angelina Zanesco, Andrew D Grant, Edson Antunes
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/3fd31b1e20ca40359c22230386b9b370
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