Increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network

Abstract Increased decision latency in alcohol use disorder (AUD) has been generally explained in terms of psychomotor slowing. Recent results suggest that AUD patients’ slowed decision-making might rather reflect alterations in the neural circuitry underlying the engagement of controlled processing...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nicola Canessa, Gianpaolo Basso, Irene Carne, Paolo Poggi, Claudia Gianelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3fd5fee3a4e84a74853473540ef91d0a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3fd5fee3a4e84a74853473540ef91d0a
record_format	dspace
spelling	oai:doaj.org-article:3fd5fee3a4e84a74853473540ef91d0a2021-12-02T19:16:47ZIncreased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network10.1038/s41598-021-99211-12045-2322https://doaj.org/article/3fd5fee3a4e84a74853473540ef91d0a2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99211-1https://doaj.org/toc/2045-2322Abstract Increased decision latency in alcohol use disorder (AUD) has been generally explained in terms of psychomotor slowing. Recent results suggest that AUD patients’ slowed decision-making might rather reflect alterations in the neural circuitry underlying the engagement of controlled processing by salient stimuli. We addressed this hypothesis by testing a relationship between decision latency at the Cambridge Gambling Task (CGT) and intrinsic brain activity in 22 individuals with AUD and 19 matched controls. CGT deliberation time was related to two complementary facets of resting-state fMRI activity, i.e. coherence and intensity, representing early biomarkers of functional changes in the intrinsic brain architecture. For both metrics, we assessed a multiple regression (to test a relationship with deliberation time in the whole sample), and an interaction analysis (to test a significantly different relationship with decision latency across groups). AUD patients’ slowed deliberation time (p < 0.025) reflected distinct facets of altered intrinsic activity in the cingulate node of the anterior salience network previously associated with the “output” motor stage of response selection. Its heightened activity in AUD patients compared with controls, tracking choice latency (p < 0.025 corrected), might represent a compensation mechanism counterbalancing the concurrent decrease of its internal coherent activity (p < 0.025 corrected). These findings provide novel insights into the intrinsic neural mechanisms underlying increased decision latency in AUD, involving decreased temporal synchronicity in networks promoting executive control by behaviourally relevant stimuli. These results pave the way to further studies assessing more subtle facets of decision-making in AUD, and their possible changes with rehabilitative treatment.Nicola CanessaGianpaolo BassoIrene CarnePaolo PoggiClaudia GianelliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicola Canessa Gianpaolo Basso Irene Carne Paolo Poggi Claudia Gianelli Increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network
description	Abstract Increased decision latency in alcohol use disorder (AUD) has been generally explained in terms of psychomotor slowing. Recent results suggest that AUD patients’ slowed decision-making might rather reflect alterations in the neural circuitry underlying the engagement of controlled processing by salient stimuli. We addressed this hypothesis by testing a relationship between decision latency at the Cambridge Gambling Task (CGT) and intrinsic brain activity in 22 individuals with AUD and 19 matched controls. CGT deliberation time was related to two complementary facets of resting-state fMRI activity, i.e. coherence and intensity, representing early biomarkers of functional changes in the intrinsic brain architecture. For both metrics, we assessed a multiple regression (to test a relationship with deliberation time in the whole sample), and an interaction analysis (to test a significantly different relationship with decision latency across groups). AUD patients’ slowed deliberation time (p < 0.025) reflected distinct facets of altered intrinsic activity in the cingulate node of the anterior salience network previously associated with the “output” motor stage of response selection. Its heightened activity in AUD patients compared with controls, tracking choice latency (p < 0.025 corrected), might represent a compensation mechanism counterbalancing the concurrent decrease of its internal coherent activity (p < 0.025 corrected). These findings provide novel insights into the intrinsic neural mechanisms underlying increased decision latency in AUD, involving decreased temporal synchronicity in networks promoting executive control by behaviourally relevant stimuli. These results pave the way to further studies assessing more subtle facets of decision-making in AUD, and their possible changes with rehabilitative treatment.
format	article
author	Nicola Canessa Gianpaolo Basso Irene Carne Paolo Poggi Claudia Gianelli
author_facet	Nicola Canessa Gianpaolo Basso Irene Carne Paolo Poggi Claudia Gianelli
author_sort	Nicola Canessa
title	Increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network
title_short	Increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network
title_full	Increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network
title_fullStr	Increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network
title_full_unstemmed	Increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network
title_sort	increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3fd5fee3a4e84a74853473540ef91d0a
work_keys_str_mv	AT nicolacanessa increaseddecisionlatencyinalcoholusedisorderreflectsalteredrestingstatesynchronyintheanteriorsaliencenetwork AT gianpaolobasso increaseddecisionlatencyinalcoholusedisorderreflectsalteredrestingstatesynchronyintheanteriorsaliencenetwork AT irenecarne increaseddecisionlatencyinalcoholusedisorderreflectsalteredrestingstatesynchronyintheanteriorsaliencenetwork AT paolopoggi increaseddecisionlatencyinalcoholusedisorderreflectsalteredrestingstatesynchronyintheanteriorsaliencenetwork AT claudiagianelli increaseddecisionlatencyinalcoholusedisorderreflectsalteredrestingstatesynchronyintheanteriorsaliencenetwork
_version_	1718376906894606336

Increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network

Ejemplares similares