Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray

Abstract Paper spray ionization (PSI) mass spectrometry (MS) is an emerging tool for ambient reaction monitoring via microdroplet reaction acceleration. PSI-MS was used to accelerate and monitor the time course of the reaction of dansyl chloride with aniline, in acetonitrile, to produce dansyl anili...

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Autores principales:	Norfatirah Muhamad Sarih, David Romero-Perez, Behnam Bastani, Monrawat Rauytanapanit, Cedric Boisdon, Thanit Praneenararat, Hairul Anuar Tajuddin, Zanariah Abdullah, Abraham K. Badu-Tawiah, Simon Maher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3fd6c95b15ba4cf19b26149394c0fe5a
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spelling	oai:doaj.org-article:3fd6c95b15ba4cf19b26149394c0fe5a2021-12-02T16:18:04ZAccelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray10.1038/s41598-020-78133-42045-2322https://doaj.org/article/3fd6c95b15ba4cf19b26149394c0fe5a2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78133-4https://doaj.org/toc/2045-2322Abstract Paper spray ionization (PSI) mass spectrometry (MS) is an emerging tool for ambient reaction monitoring via microdroplet reaction acceleration. PSI-MS was used to accelerate and monitor the time course of the reaction of dansyl chloride with aniline, in acetonitrile, to produce dansyl aniline. Three distinct PSI arrangements were explored in this study representing alternative approaches for sample loading and interaction; conventional single tip as well as two novel setups, a dual-tip and a co-axial arrangement were designed so as to limit any on-paper interaction between reagents. The effect on product abundance was investigated using these different paper configurations as it relates to the time course and distance of microdroplet travel. It was observed that product yield increases at a given distance and then decreases thereafter for all PSI configurations. The fluorescent property of the product (dansyl aniline) was used to visually inspect the reaction progress on the paper substrate during the spraying process. Amongst the variety of sample loading methods the novel dual-tip arrangement showed an increased product yield and microdroplet density, whilst avoiding any on-paper interaction between the reagents.Norfatirah Muhamad SarihDavid Romero-PerezBehnam BastaniMonrawat RauytanapanitCedric BoisdonThanit PraneenararatHairul Anuar TajuddinZanariah AbdullahAbraham K. Badu-TawiahSimon MaherNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Norfatirah Muhamad Sarih David Romero-Perez Behnam Bastani Monrawat Rauytanapanit Cedric Boisdon Thanit Praneenararat Hairul Anuar Tajuddin Zanariah Abdullah Abraham K. Badu-Tawiah Simon Maher Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray
description	Abstract Paper spray ionization (PSI) mass spectrometry (MS) is an emerging tool for ambient reaction monitoring via microdroplet reaction acceleration. PSI-MS was used to accelerate and monitor the time course of the reaction of dansyl chloride with aniline, in acetonitrile, to produce dansyl aniline. Three distinct PSI arrangements were explored in this study representing alternative approaches for sample loading and interaction; conventional single tip as well as two novel setups, a dual-tip and a co-axial arrangement were designed so as to limit any on-paper interaction between reagents. The effect on product abundance was investigated using these different paper configurations as it relates to the time course and distance of microdroplet travel. It was observed that product yield increases at a given distance and then decreases thereafter for all PSI configurations. The fluorescent property of the product (dansyl aniline) was used to visually inspect the reaction progress on the paper substrate during the spraying process. Amongst the variety of sample loading methods the novel dual-tip arrangement showed an increased product yield and microdroplet density, whilst avoiding any on-paper interaction between the reagents.
format	article
author	Norfatirah Muhamad Sarih David Romero-Perez Behnam Bastani Monrawat Rauytanapanit Cedric Boisdon Thanit Praneenararat Hairul Anuar Tajuddin Zanariah Abdullah Abraham K. Badu-Tawiah Simon Maher
author_facet	Norfatirah Muhamad Sarih David Romero-Perez Behnam Bastani Monrawat Rauytanapanit Cedric Boisdon Thanit Praneenararat Hairul Anuar Tajuddin Zanariah Abdullah Abraham K. Badu-Tawiah Simon Maher
author_sort	Norfatirah Muhamad Sarih
title	Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray
title_short	Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray
title_full	Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray
title_fullStr	Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray
title_full_unstemmed	Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray
title_sort	accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3fd6c95b15ba4cf19b26149394c0fe5a
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Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray

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