A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury

Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, 56000, MalaysiaCorrespondence: Soelaiman Ima-NirwanaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob...

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Autores principales:	Wong SK, Chin KY, Ima-Nirwana S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	andrographis myocardial infarction inflammation oxidative stress apoptosis fibrosis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3fdab652f75d468abf814dfa1ed12be5
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spelling	oai:doaj.org-article:3fdab652f75d468abf814dfa1ed12be52021-11-09T18:40:35ZA review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury1177-8881https://doaj.org/article/3fdab652f75d468abf814dfa1ed12be52021-11-01T00:00:00Zhttps://www.dovepress.com/a-review-on-the-molecular-basis-underlying-the-protective-effects-of-a-peer-reviewed-fulltext-article-DDDThttps://doaj.org/toc/1177-8881Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, 56000, MalaysiaCorrespondence: Soelaiman Ima-NirwanaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, MalaysiaTel +62 603-9145 9579Fax +62 603-9145 9545Email imasoel@gmail.comAbstract: Andrographolide is the major compound found in the medicinal plant, Andrographis paniculata (Burm.f.) Nees, which accounts for its medicinal properties. Both the plant extract and compound have been reported to exhibit potential cardiovascular activities. This review summarises related studies describing the biological activities and target mechanisms of A. paniculata and andrographolide in vivo and in vitro. The current evidence unambiguously indicated the protective effects provided by A. paniculata and andrographolide administration against myocardial injury. The intervention ameliorates the symptoms of myocardial injury by interfering with the inductive phase of a) inflammatory response mediated by nuclear factor-kappa B (NF-κB), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription 3 (STAT3) signalling molecules; b) oxidative stress via activation of nuclear factor erythroid 2-related factor (Nrf-2) and reduction of enzymes responsible for generating reactive oxygen and nitrogen species; c) intrinsic and extrinsic mechanisms in apoptosis regulated by upstream insulin-like growth factor-1 receptor (IGF-1R) and peroxisome proliferator-activated receptor-alpha (PPAR-α); d) profibrotic growth factors thus reducing cardiac fibrosis, improving endothelial function and fibrinolytic function. In conclusion, A. paniculata and andrographolide possess therapeutic potential in the management of myocardial injury, which requires further validation in human clinical trials.Keywords: Andrographis, myocardial infarction, inflammation, oxidative stress, apoptosis, fibrosisWong SKChin KYIma-Nirwana SDove Medical Pressarticleandrographismyocardial infarctioninflammationoxidative stressapoptosisfibrosisTherapeutics. PharmacologyRM1-950ENDrug Design, Development and Therapy, Vol Volume 15, Pp 4615-4632 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	andrographis myocardial infarction inflammation oxidative stress apoptosis fibrosis Therapeutics. Pharmacology RM1-950
spellingShingle	andrographis myocardial infarction inflammation oxidative stress apoptosis fibrosis Therapeutics. Pharmacology RM1-950 Wong SK Chin KY Ima-Nirwana S A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury
description	Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, 56000, MalaysiaCorrespondence: Soelaiman Ima-NirwanaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, MalaysiaTel +62 603-9145 9579Fax +62 603-9145 9545Email imasoel@gmail.comAbstract: Andrographolide is the major compound found in the medicinal plant, Andrographis paniculata (Burm.f.) Nees, which accounts for its medicinal properties. Both the plant extract and compound have been reported to exhibit potential cardiovascular activities. This review summarises related studies describing the biological activities and target mechanisms of A. paniculata and andrographolide in vivo and in vitro. The current evidence unambiguously indicated the protective effects provided by A. paniculata and andrographolide administration against myocardial injury. The intervention ameliorates the symptoms of myocardial injury by interfering with the inductive phase of a) inflammatory response mediated by nuclear factor-kappa B (NF-κB), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription 3 (STAT3) signalling molecules; b) oxidative stress via activation of nuclear factor erythroid 2-related factor (Nrf-2) and reduction of enzymes responsible for generating reactive oxygen and nitrogen species; c) intrinsic and extrinsic mechanisms in apoptosis regulated by upstream insulin-like growth factor-1 receptor (IGF-1R) and peroxisome proliferator-activated receptor-alpha (PPAR-α); d) profibrotic growth factors thus reducing cardiac fibrosis, improving endothelial function and fibrinolytic function. In conclusion, A. paniculata and andrographolide possess therapeutic potential in the management of myocardial injury, which requires further validation in human clinical trials.Keywords: Andrographis, myocardial infarction, inflammation, oxidative stress, apoptosis, fibrosis
format	article
author	Wong SK Chin KY Ima-Nirwana S
author_facet	Wong SK Chin KY Ima-Nirwana S
author_sort	Wong SK
title	A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury
title_short	A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury
title_full	A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury
title_fullStr	A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury
title_full_unstemmed	A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury
title_sort	review on the molecular basis underlying the protective effects of andrographis paniculata and andrographolide against myocardial injury
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/3fdab652f75d468abf814dfa1ed12be5
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A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury

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