Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm

Rene Hernandez-Delgadillo1, Donaji Velasco-Arias2, David Diaz2, Katiushka Arevalo-Ni&ntilde;o1, Marianela Garza-Enriquez1, Myriam A De la Garza-Ramos1, Claudio Cabral-Romero11Instituto de Biotecnologia, Centro de Investigacion y Desarrollo en Ciencias de la Salud, CIDICS, Facultad de Odontol...

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Autores principales:	Hernandez-Delgadillo R, Velasco-Arias D, Diaz D, Arevalo-Ni&ntilde;o K, Garza-Enriquez M, De la Garza-Ramos MA, Cabral-Romero C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3fdeef27cf904ec9b536f5085deb4887
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spelling	oai:doaj.org-article:3fdeef27cf904ec9b536f5085deb48872021-12-02T02:42:32ZZerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm1176-91141178-2013https://doaj.org/article/3fdeef27cf904ec9b536f5085deb48872012-04-01T00:00:00Zhttp://www.dovepress.com/zerovalent-bismuth-nanoparticles-inhibit-streptococcus-mutans-growth-a-a9762https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Rene Hernandez-Delgadillo1, Donaji Velasco-Arias2, David Diaz2, Katiushka Arevalo-Ni&ntilde;o1, Marianela Garza-Enriquez1, Myriam A De la Garza-Ramos1, Claudio Cabral-Romero11Instituto de Biotecnologia, Centro de Investigacion y Desarrollo en Ciencias de la Salud, CIDICS, Facultad de Odontologia, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, Nuevo Leon, 2Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Distrito Federal, MexicoBackground and methods: Despite continuous efforts, the increasing prevalence of resistance among pathogenic bacteria to common antibiotics has become one of the most significant concerns in modern medicine. Nanostructured materials are used in many fields, including biological sciences and medicine. While some bismuth derivatives has been used in medicine to treat vomiting, nausea, diarrhea, and stomach pain, the biocidal activity of zerovalent bismuth nanoparticles has not yet been studied. The objective of this investigation was to analyze the antimicrobial activity of bismuth nanoparticles against oral bacteria and their antibiofilm capabilities.Results: Our results showed that stable colloidal bismuth nanoparticles had 69% antimicrobial activity against Streptococcus mutans growth and achieved complete inhibition of biofilm formation. These results are similar to those obtained with chlorhexidine, the most commonly used oral antiseptic agent. The minimal inhibitory concentration of bismuth nanoparticles that interfered with S. mutans growth was 0.5 mM.Conclusion: These results suggest that zerovalent bismuth nanoparticles could be an interesting antimicrobial agent to be incorporated into an oral antiseptic preparation.Keywords: zerovalent bismuth nanoparticles, antimicrobial agent, biofilm, Streptococcus mutansHernandez-Delgadillo RVelasco-Arias DDiaz DArevalo-Ni&ntilde;o KGarza-Enriquez MDe la Garza-Ramos MACabral-Romero CDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 2109-2113 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Hernandez-Delgadillo R Velasco-Arias D Diaz D Arevalo-Ni&ntilde;o K Garza-Enriquez M De la Garza-Ramos MA Cabral-Romero C Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm
description	Rene Hernandez-Delgadillo1, Donaji Velasco-Arias2, David Diaz2, Katiushka Arevalo-Ni&ntilde;o1, Marianela Garza-Enriquez1, Myriam A De la Garza-Ramos1, Claudio Cabral-Romero11Instituto de Biotecnologia, Centro de Investigacion y Desarrollo en Ciencias de la Salud, CIDICS, Facultad de Odontologia, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, Nuevo Leon, 2Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Distrito Federal, MexicoBackground and methods: Despite continuous efforts, the increasing prevalence of resistance among pathogenic bacteria to common antibiotics has become one of the most significant concerns in modern medicine. Nanostructured materials are used in many fields, including biological sciences and medicine. While some bismuth derivatives has been used in medicine to treat vomiting, nausea, diarrhea, and stomach pain, the biocidal activity of zerovalent bismuth nanoparticles has not yet been studied. The objective of this investigation was to analyze the antimicrobial activity of bismuth nanoparticles against oral bacteria and their antibiofilm capabilities.Results: Our results showed that stable colloidal bismuth nanoparticles had 69% antimicrobial activity against Streptococcus mutans growth and achieved complete inhibition of biofilm formation. These results are similar to those obtained with chlorhexidine, the most commonly used oral antiseptic agent. The minimal inhibitory concentration of bismuth nanoparticles that interfered with S. mutans growth was 0.5 mM.Conclusion: These results suggest that zerovalent bismuth nanoparticles could be an interesting antimicrobial agent to be incorporated into an oral antiseptic preparation.Keywords: zerovalent bismuth nanoparticles, antimicrobial agent, biofilm, Streptococcus mutans
format	article
author	Hernandez-Delgadillo R Velasco-Arias D Diaz D Arevalo-Ni&ntilde;o K Garza-Enriquez M De la Garza-Ramos MA Cabral-Romero C
author_facet	Hernandez-Delgadillo R Velasco-Arias D Diaz D Arevalo-Ni&ntilde;o K Garza-Enriquez M De la Garza-Ramos MA Cabral-Romero C
author_sort	Hernandez-Delgadillo R
title	Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm
title_short	Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm
title_full	Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm
title_fullStr	Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm
title_full_unstemmed	Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm
title_sort	zerovalent bismuth nanoparticles inhibit streptococcus mutans growth and formation of biofilm
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/3fdeef27cf904ec9b536f5085deb4887
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Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm

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