Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor

Oligodendrocyte precursor cell (OPC) proliferation and differentiation is greater in white matter than gray matter. Here, the authors show regulation of OPC proliferation in white matter involved trans-activation of PDGFRα on OPCs via Nrp1 expressed by adjacent microglia.

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Autores principales:	Amin Sherafat, Friederike Pfeiffer, Alexander M. Reiss, William M. Wood, Akiko Nishiyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3fe090a54fae4abb94913b0060155aa9
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spelling	oai:doaj.org-article:3fe090a54fae4abb94913b0060155aa92021-12-02T14:30:27ZMicroglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor10.1038/s41467-021-22532-22041-1723https://doaj.org/article/3fe090a54fae4abb94913b0060155aa92021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22532-2https://doaj.org/toc/2041-1723Oligodendrocyte precursor cell (OPC) proliferation and differentiation is greater in white matter than gray matter. Here, the authors show regulation of OPC proliferation in white matter involved trans-activation of PDGFRα on OPCs via Nrp1 expressed by adjacent microglia.Amin SherafatFriederike PfeifferAlexander M. ReissWilliam M. WoodAkiko NishiyamaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amin Sherafat Friederike Pfeiffer Alexander M. Reiss William M. Wood Akiko Nishiyama Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor
description	Oligodendrocyte precursor cell (OPC) proliferation and differentiation is greater in white matter than gray matter. Here, the authors show regulation of OPC proliferation in white matter involved trans-activation of PDGFRα on OPCs via Nrp1 expressed by adjacent microglia.
format	article
author	Amin Sherafat Friederike Pfeiffer Alexander M. Reiss William M. Wood Akiko Nishiyama
author_facet	Amin Sherafat Friederike Pfeiffer Alexander M. Reiss William M. Wood Akiko Nishiyama
author_sort	Amin Sherafat
title	Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor
title_short	Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor
title_full	Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor
title_fullStr	Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor
title_full_unstemmed	Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor
title_sort	microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3fe090a54fae4abb94913b0060155aa9
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Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor

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