Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients

Abstract The purpose of this study is to evaluate the levels and clinical diagnosis value of CA15-3, CEA, and SF in canine mammary gland tumors (CMGTs). In this study, the levels of tissues/serum CA15-3, CEA, and SF in 178 CMGT patients or healthy dogs were determined by ELISA and qRT-PCR assay. CA1...

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Autores principales:	Yuying Fan, Xiaoli Ren, Xuesong Liu, Dongmei Shi, Enshuang Xu, Shuang Wang, Yun Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3fe16fe04ee14a4a9ab29e7112d87c30
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spelling	oai:doaj.org-article:3fe16fe04ee14a4a9ab29e7112d87c302021-12-02T13:24:25ZCombined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients10.1038/s41598-021-85029-42045-2322https://doaj.org/article/3fe16fe04ee14a4a9ab29e7112d87c302021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85029-4https://doaj.org/toc/2045-2322Abstract The purpose of this study is to evaluate the levels and clinical diagnosis value of CA15-3, CEA, and SF in canine mammary gland tumors (CMGTs). In this study, the levels of tissues/serum CA15-3, CEA, and SF in 178 CMGT patients or healthy dogs were determined by ELISA and qRT-PCR assay. CA15-3, CEA, and SF levels of the malignant tumor group were significantly higher than that of the benign tumor group and the healthy control group. In the malignant tumor group, CA15-3 held a sensitivity of 51.8%, a specificity of 93.9%, and an accuracy of 76.8%. The sensitivity, specificity, and accuracy of CEA were 44.6%, 84.1%, and 68.1% respectively. SF held a sensitivity of 62.5%, a specificity of 85.4%, and an accuracy of 76.1%. SF showed the highest sensitivity and CA15-3 showed the highest specificity. The sensitivity, specificity, and accuracy of the combined detection of the three biomarkers in malignant tumor groups were 80.4%, 78.0%, and 80.0%, respectively, therefore combined detection increased sensitivity and accuracy but decreased specificity. In conclusion, the combined detection of serum/tissue markers CA15-3, CEA, and SF may improve the detection sensitivity of CMGTs, providing reference value for clinical application.Yuying FanXiaoli RenXuesong LiuDongmei ShiEnshuang XuShuang WangYun LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuying Fan Xiaoli Ren Xuesong Liu Dongmei Shi Enshuang Xu Shuang Wang Yun Liu Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients
description	Abstract The purpose of this study is to evaluate the levels and clinical diagnosis value of CA15-3, CEA, and SF in canine mammary gland tumors (CMGTs). In this study, the levels of tissues/serum CA15-3, CEA, and SF in 178 CMGT patients or healthy dogs were determined by ELISA and qRT-PCR assay. CA15-3, CEA, and SF levels of the malignant tumor group were significantly higher than that of the benign tumor group and the healthy control group. In the malignant tumor group, CA15-3 held a sensitivity of 51.8%, a specificity of 93.9%, and an accuracy of 76.8%. The sensitivity, specificity, and accuracy of CEA were 44.6%, 84.1%, and 68.1% respectively. SF held a sensitivity of 62.5%, a specificity of 85.4%, and an accuracy of 76.1%. SF showed the highest sensitivity and CA15-3 showed the highest specificity. The sensitivity, specificity, and accuracy of the combined detection of the three biomarkers in malignant tumor groups were 80.4%, 78.0%, and 80.0%, respectively, therefore combined detection increased sensitivity and accuracy but decreased specificity. In conclusion, the combined detection of serum/tissue markers CA15-3, CEA, and SF may improve the detection sensitivity of CMGTs, providing reference value for clinical application.
format	article
author	Yuying Fan Xiaoli Ren Xuesong Liu Dongmei Shi Enshuang Xu Shuang Wang Yun Liu
author_facet	Yuying Fan Xiaoli Ren Xuesong Liu Dongmei Shi Enshuang Xu Shuang Wang Yun Liu
author_sort	Yuying Fan
title	Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients
title_short	Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients
title_full	Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients
title_fullStr	Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients
title_full_unstemmed	Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients
title_sort	combined detection of ca15-3, cea, and sf in serum and tissue of canine mammary gland tumor patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3fe16fe04ee14a4a9ab29e7112d87c30
work_keys_str_mv	AT yuyingfan combineddetectionofca153ceaandsfinserumandtissueofcaninemammaryglandtumorpatients AT xiaoliren combineddetectionofca153ceaandsfinserumandtissueofcaninemammaryglandtumorpatients AT xuesongliu combineddetectionofca153ceaandsfinserumandtissueofcaninemammaryglandtumorpatients AT dongmeishi combineddetectionofca153ceaandsfinserumandtissueofcaninemammaryglandtumorpatients AT enshuangxu combineddetectionofca153ceaandsfinserumandtissueofcaninemammaryglandtumorpatients AT shuangwang combineddetectionofca153ceaandsfinserumandtissueofcaninemammaryglandtumorpatients AT yunliu combineddetectionofca153ceaandsfinserumandtissueofcaninemammaryglandtumorpatients
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Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients

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