Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy

Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy

Abstract Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form of intellectual disability and autism spectrum disorder. FXS mouse models display clinically-relevant phenotypes, such as increased anxiety and hyperactivity. Despite their availabi...

Full description

Saved in:
Bibliographic Details
Main Authors: Samantha T. Reyes, Robert M. J. Deacon, Scarlett G. Guo, Francisco J. Altimiras, Jessa B. Castillo, Berend van der Wildt, Aimara P. Morales, Jun Hyung Park, Daniel Klamer, Jarrett Rosenberg, Lindsay M. Oberman, Nell Rebowe, Jeffrey Sprouse, Christopher U. Missling, Christopher R. McCurdy, Patricia Cogram, Walter E. Kaufmann, Frederick T. Chin
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/3fe726770d9a49e4a8f47d5b5a43daca
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items