Circulating Biomarkers and Cardiac Structure and Function in Rheumatoid Arthritis

Background: Rheumatoid arthritis (RA) increases the risk for abnormalities of the cardiac structure and function, which may lead to heart failure (HF). Studying the association between circulating biomarkers and echocardiographic parameters is important to screen patients with RA with a higher risk...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Masatake Kobayashi, Maria Betânia Ferreira, Rita Quelhas Costa, Tomás Fonseca, José Carlos Oliveira, António Marinho, Henrique Cyrne Carvalho, Nicolas Girerd, Patrick Rossignol, Faiez Zannad, Patrícia Rodrigues, João Pedro Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	rheumatoid arthritis heart failure with preserved ejection fraction echocardiogram circulating biomarkers prognosis Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/3fe8a12e6a0d42de9f6ee17b76f28cb2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3fe8a12e6a0d42de9f6ee17b76f28cb2
record_format	dspace
spelling	oai:doaj.org-article:3fe8a12e6a0d42de9f6ee17b76f28cb22021-11-18T06:17:35ZCirculating Biomarkers and Cardiac Structure and Function in Rheumatoid Arthritis2297-055X10.3389/fcvm.2021.754784https://doaj.org/article/3fe8a12e6a0d42de9f6ee17b76f28cb22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.754784/fullhttps://doaj.org/toc/2297-055XBackground: Rheumatoid arthritis (RA) increases the risk for abnormalities of the cardiac structure and function, which may lead to heart failure (HF). Studying the association between circulating biomarkers and echocardiographic parameters is important to screen patients with RA with a higher risk of cardiac dysfunction.Aim: To study the association between circulating biomarkers and echocardiographic parameters in patients with RA.Methods: Echocardiography was performed in 355 patients with RA from RA Porto cohort and the associations between echocardiographic characteristics and 94 circulating biomarkers were assessed. These associations were also assessed in the Metabolic Road to Diastolic Heart Failure (MEDIA-DHF) [392 patients with HF with preserved ejection fraction (HFpEF)] and the Suivi Temporaire Annuel Non-Invasif de la Santé des Lorrains Assurés Sociaux (STANISLAS) (1,672 healthy population) cohorts.Results: In the RA Porto cohort, mean age was 58 ± 13 years, 23% were males and mean RA duration was 12 ± 10 years. After adjustment and multiple testing correction, left ventricular mass index (LVMi), left atrial volume index (LAVi), and E/e′ were independently associated with biomarkers reflecting inflammation [i.e., bone morphogenetic protein 9 (BMP9), pentraxin-related protein 3 (PTX3), tumor necrosis factor receptor superfamily member 11a (TNFRSF11A)], extracellular matrix remodeling [i.e., placental growth factor (PGF)], congestion [i.e., N-terminal pro-brain natriuretic peptide (NT-proBNP), adrenomedullin (ADM)], and myocardial injury (e.g., troponin). Greater LVMi [hazard ratio (HR) (95% CI) per 1 g/m2 = 1.03 (1.02–1.04), p < 0.001], LAVi [HR (95% CI) per 1 ml/m2 = 1.03 (1.01–1.06), p < 0.001], and E/e′ [HR (95% CI) per 1 = 1.08 (1.04–1.13), p < 0.001] were associated with higher rates of cardiovascular events. These associations were externally replicated in patients with HFpEF and asymptomatic individuals.Conclusion: Circulating biomarkers reflecting inflammation, extracellular matrix remodeling, congestion, and myocardial injury were associated with underlying alterations of cardiac structure and function. Biomarkers might be used for the screening of cardiac alterations in patients with RA.Masatake KobayashiMaria Betânia FerreiraMaria Betânia FerreiraMaria Betânia FerreiraRita Quelhas CostaTomás FonsecaJosé Carlos OliveiraAntónio MarinhoAntónio MarinhoHenrique Cyrne CarvalhoHenrique Cyrne CarvalhoHenrique Cyrne CarvalhoNicolas GirerdPatrick RossignolFaiez ZannadPatrícia RodriguesPatrícia RodriguesPatrícia RodriguesJoão Pedro FerreiraJoão Pedro FerreiraFrontiers Media S.A.articlerheumatoid arthritisheart failure with preserved ejection fractionechocardiogramcirculating biomarkersprognosisDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rheumatoid arthritis heart failure with preserved ejection fraction echocardiogram circulating biomarkers prognosis Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	rheumatoid arthritis heart failure with preserved ejection fraction echocardiogram circulating biomarkers prognosis Diseases of the circulatory (Cardiovascular) system RC666-701 Masatake Kobayashi Maria Betânia Ferreira Maria Betânia Ferreira Maria Betânia Ferreira Rita Quelhas Costa Tomás Fonseca José Carlos Oliveira António Marinho António Marinho Henrique Cyrne Carvalho Henrique Cyrne Carvalho Henrique Cyrne Carvalho Nicolas Girerd Patrick Rossignol Faiez Zannad Patrícia Rodrigues Patrícia Rodrigues Patrícia Rodrigues João Pedro Ferreira João Pedro Ferreira Circulating Biomarkers and Cardiac Structure and Function in Rheumatoid Arthritis
description	Background: Rheumatoid arthritis (RA) increases the risk for abnormalities of the cardiac structure and function, which may lead to heart failure (HF). Studying the association between circulating biomarkers and echocardiographic parameters is important to screen patients with RA with a higher risk of cardiac dysfunction.Aim: To study the association between circulating biomarkers and echocardiographic parameters in patients with RA.Methods: Echocardiography was performed in 355 patients with RA from RA Porto cohort and the associations between echocardiographic characteristics and 94 circulating biomarkers were assessed. These associations were also assessed in the Metabolic Road to Diastolic Heart Failure (MEDIA-DHF) [392 patients with HF with preserved ejection fraction (HFpEF)] and the Suivi Temporaire Annuel Non-Invasif de la Santé des Lorrains Assurés Sociaux (STANISLAS) (1,672 healthy population) cohorts.Results: In the RA Porto cohort, mean age was 58 ± 13 years, 23% were males and mean RA duration was 12 ± 10 years. After adjustment and multiple testing correction, left ventricular mass index (LVMi), left atrial volume index (LAVi), and E/e′ were independently associated with biomarkers reflecting inflammation [i.e., bone morphogenetic protein 9 (BMP9), pentraxin-related protein 3 (PTX3), tumor necrosis factor receptor superfamily member 11a (TNFRSF11A)], extracellular matrix remodeling [i.e., placental growth factor (PGF)], congestion [i.e., N-terminal pro-brain natriuretic peptide (NT-proBNP), adrenomedullin (ADM)], and myocardial injury (e.g., troponin). Greater LVMi [hazard ratio (HR) (95% CI) per 1 g/m2 = 1.03 (1.02–1.04), p < 0.001], LAVi [HR (95% CI) per 1 ml/m2 = 1.03 (1.01–1.06), p < 0.001], and E/e′ [HR (95% CI) per 1 = 1.08 (1.04–1.13), p < 0.001] were associated with higher rates of cardiovascular events. These associations were externally replicated in patients with HFpEF and asymptomatic individuals.Conclusion: Circulating biomarkers reflecting inflammation, extracellular matrix remodeling, congestion, and myocardial injury were associated with underlying alterations of cardiac structure and function. Biomarkers might be used for the screening of cardiac alterations in patients with RA.
format	article
author	Masatake Kobayashi Maria Betânia Ferreira Maria Betânia Ferreira Maria Betânia Ferreira Rita Quelhas Costa Tomás Fonseca José Carlos Oliveira António Marinho António Marinho Henrique Cyrne Carvalho Henrique Cyrne Carvalho Henrique Cyrne Carvalho Nicolas Girerd Patrick Rossignol Faiez Zannad Patrícia Rodrigues Patrícia Rodrigues Patrícia Rodrigues João Pedro Ferreira João Pedro Ferreira
author_facet	Masatake Kobayashi Maria Betânia Ferreira Maria Betânia Ferreira Maria Betânia Ferreira Rita Quelhas Costa Tomás Fonseca José Carlos Oliveira António Marinho António Marinho Henrique Cyrne Carvalho Henrique Cyrne Carvalho Henrique Cyrne Carvalho Nicolas Girerd Patrick Rossignol Faiez Zannad Patrícia Rodrigues Patrícia Rodrigues Patrícia Rodrigues João Pedro Ferreira João Pedro Ferreira
author_sort	Masatake Kobayashi
title	Circulating Biomarkers and Cardiac Structure and Function in Rheumatoid Arthritis
title_short	Circulating Biomarkers and Cardiac Structure and Function in Rheumatoid Arthritis
title_full	Circulating Biomarkers and Cardiac Structure and Function in Rheumatoid Arthritis
title_fullStr	Circulating Biomarkers and Cardiac Structure and Function in Rheumatoid Arthritis
title_full_unstemmed	Circulating Biomarkers and Cardiac Structure and Function in Rheumatoid Arthritis
title_sort	circulating biomarkers and cardiac structure and function in rheumatoid arthritis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3fe8a12e6a0d42de9f6ee17b76f28cb2
work_keys_str_mv	AT masatakekobayashi circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT mariabetaniaferreira circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT mariabetaniaferreira circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT mariabetaniaferreira circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT ritaquelhascosta circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT tomasfonseca circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT josecarlosoliveira circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT antoniomarinho circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT antoniomarinho circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT henriquecyrnecarvalho circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT henriquecyrnecarvalho circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT henriquecyrnecarvalho circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT nicolasgirerd circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT patrickrossignol circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT faiezzannad circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT patriciarodrigues circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT patriciarodrigues circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT patriciarodrigues circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT joaopedroferreira circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis AT joaopedroferreira circulatingbiomarkersandcardiacstructureandfunctioninrheumatoidarthritis
_version_	1718424531375226880

Circulating Biomarkers and Cardiac Structure and Function in Rheumatoid Arthritis

Ejemplares similares