Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.

Affective symptoms such as anxiety and depression are frequently observed in patients with epilepsy. The mechanisms of comorbidity of epilepsy and affective disorders, however, remain unclear. Diverse models are traditionally used in epilepsy research, including the status epilepticus (SE) model in...

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Autores principales:	Marion Inostroza, Elena Cid, Liset Menendez de la Prida, Carmen Sandi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3fe9ac71a84c4063a5a46c174e62c05f
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spelling	oai:doaj.org-article:3fe9ac71a84c4063a5a46c174e62c05f2021-11-18T07:15:22ZDifferent emotional disturbances in two experimental models of temporal lobe epilepsy in rats.1932-620310.1371/journal.pone.0038959https://doaj.org/article/3fe9ac71a84c4063a5a46c174e62c05f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22720001/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Affective symptoms such as anxiety and depression are frequently observed in patients with epilepsy. The mechanisms of comorbidity of epilepsy and affective disorders, however, remain unclear. Diverse models are traditionally used in epilepsy research, including the status epilepticus (SE) model in rats, which are aimed at generating chronic epileptic animals; however, the implications of different SE models and rat strains in emotional behaviors has not been reported. To address this issue, we examined the emotional sequelae of two SE models of temporal lobe epilepsy (TLE)--the lithium-pilocarpine (LIP) model and the kainic acid (KA) model--in two different rat strains (Wistar and Sprague-Dawley), which differ significantly in the pattern and extent of TLE-associated brain lesions. We found differences between LIP- and KA-treated animals in tests for depression-like and anxiety-like behaviors, as well as differences in plasma corticosterone levels. Whereas only LIP-treated rats displayed increased motivation to consume saccharin, both SE models led to reduced motivation for social contact, with LIP-treated animals being particularly affected. Evaluation of behavior in the open field test indicated very low levels of anxiety in LIP-treated rats and a mild decrease in KA-treated rats compared to controls. After exposure to a battery of behavioral tests, plasma corticosterone levels were increased only in LIP-treated animals. This hyperactivity in the hypothalamus-pituitary-adrenocortical (HPA) axis was highly correlated with performance in the open field test and the social interaction test, suggesting that comorbidity of epilepsy and emotional behaviors might also be related to other factors such as HPA axis function. Our results indicate that altered emotional behaviors are not inherent to the epileptic condition in experimental TLE; instead, they likely reflect alterations in anxiety levels related to model-dependent dysregulation of the HPA axis.Marion InostrozaElena CidLiset Menendez de la PridaCarmen SandiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e38959 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marion Inostroza Elena Cid Liset Menendez de la Prida Carmen Sandi Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.
description	Affective symptoms such as anxiety and depression are frequently observed in patients with epilepsy. The mechanisms of comorbidity of epilepsy and affective disorders, however, remain unclear. Diverse models are traditionally used in epilepsy research, including the status epilepticus (SE) model in rats, which are aimed at generating chronic epileptic animals; however, the implications of different SE models and rat strains in emotional behaviors has not been reported. To address this issue, we examined the emotional sequelae of two SE models of temporal lobe epilepsy (TLE)--the lithium-pilocarpine (LIP) model and the kainic acid (KA) model--in two different rat strains (Wistar and Sprague-Dawley), which differ significantly in the pattern and extent of TLE-associated brain lesions. We found differences between LIP- and KA-treated animals in tests for depression-like and anxiety-like behaviors, as well as differences in plasma corticosterone levels. Whereas only LIP-treated rats displayed increased motivation to consume saccharin, both SE models led to reduced motivation for social contact, with LIP-treated animals being particularly affected. Evaluation of behavior in the open field test indicated very low levels of anxiety in LIP-treated rats and a mild decrease in KA-treated rats compared to controls. After exposure to a battery of behavioral tests, plasma corticosterone levels were increased only in LIP-treated animals. This hyperactivity in the hypothalamus-pituitary-adrenocortical (HPA) axis was highly correlated with performance in the open field test and the social interaction test, suggesting that comorbidity of epilepsy and emotional behaviors might also be related to other factors such as HPA axis function. Our results indicate that altered emotional behaviors are not inherent to the epileptic condition in experimental TLE; instead, they likely reflect alterations in anxiety levels related to model-dependent dysregulation of the HPA axis.
format	article
author	Marion Inostroza Elena Cid Liset Menendez de la Prida Carmen Sandi
author_facet	Marion Inostroza Elena Cid Liset Menendez de la Prida Carmen Sandi
author_sort	Marion Inostroza
title	Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.
title_short	Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.
title_full	Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.
title_fullStr	Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.
title_full_unstemmed	Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.
title_sort	different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3fe9ac71a84c4063a5a46c174e62c05f
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_version_	1718423720749432832

Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.

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