Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells
Single strand breaks represent the most common form of DNA damage yet no methods to map them in a genome-wide fashion at single nucleotide resolution exist. Here the authors develop such a method and apply to uncover patterns of single-strand DNA “breakome” in different biological conditions.
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Nature Portfolio
2019
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oai:doaj.org-article:3feb697ac4a94e7e834ab5f5f7ce2e502021-12-02T17:02:19ZNovel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells10.1038/s41467-019-13602-72041-1723https://doaj.org/article/3feb697ac4a94e7e834ab5f5f7ce2e502019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13602-7https://doaj.org/toc/2041-1723Single strand breaks represent the most common form of DNA damage yet no methods to map them in a genome-wide fashion at single nucleotide resolution exist. Here the authors develop such a method and apply to uncover patterns of single-strand DNA “breakome” in different biological conditions.Huifen CaoLorena Salazar-GarcíaFan GaoThor WahlestedtChun-Lin WuXueer HanYe CaiDongyang XuFang WangLu TangNatalie RicciardiDingDing CaiHuifang WangMario P. S. ChinJames A. TimmonsClaes WahlestedtPhilipp KapranovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Huifen Cao Lorena Salazar-García Fan Gao Thor Wahlestedt Chun-Lin Wu Xueer Han Ye Cai Dongyang Xu Fang Wang Lu Tang Natalie Ricciardi DingDing Cai Huifang Wang Mario P. S. Chin James A. Timmons Claes Wahlestedt Philipp Kapranov Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells |
| description |
Single strand breaks represent the most common form of DNA damage yet no methods to map them in a genome-wide fashion at single nucleotide resolution exist. Here the authors develop such a method and apply to uncover patterns of single-strand DNA “breakome” in different biological conditions. |
| format |
article |
| author |
Huifen Cao Lorena Salazar-García Fan Gao Thor Wahlestedt Chun-Lin Wu Xueer Han Ye Cai Dongyang Xu Fang Wang Lu Tang Natalie Ricciardi DingDing Cai Huifang Wang Mario P. S. Chin James A. Timmons Claes Wahlestedt Philipp Kapranov |
| author_facet |
Huifen Cao Lorena Salazar-García Fan Gao Thor Wahlestedt Chun-Lin Wu Xueer Han Ye Cai Dongyang Xu Fang Wang Lu Tang Natalie Ricciardi DingDing Cai Huifang Wang Mario P. S. Chin James A. Timmons Claes Wahlestedt Philipp Kapranov |
| author_sort |
Huifen Cao |
| title |
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells |
| title_short |
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells |
| title_full |
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells |
| title_fullStr |
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells |
| title_full_unstemmed |
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells |
| title_sort |
novel approach reveals genomic landscapes of single-strand dna breaks with nucleotide resolution in human cells |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/3feb697ac4a94e7e834ab5f5f7ce2e50 |
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