Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

Single strand breaks represent the most common form of DNA damage yet no methods to map them in a genome-wide fashion at single nucleotide resolution exist. Here the authors develop such a method and apply to uncover patterns of single-strand DNA “breakome” in different biological conditions.

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Detalles Bibliográficos
Autores principales: Huifen Cao, Lorena Salazar-García, Fan Gao, Thor Wahlestedt, Chun-Lin Wu, Xueer Han, Ye Cai, Dongyang Xu, Fang Wang, Lu Tang, Natalie Ricciardi, DingDing Cai, Huifang Wang, Mario P. S. Chin, James A. Timmons, Claes Wahlestedt, Philipp Kapranov
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/3feb697ac4a94e7e834ab5f5f7ce2e50
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