Euphorbia Factor L2 ameliorates the Progression of K/BxN Serum-Induced Arthritis by Blocking TLR7 Mediated IRAK4/IKKβ/IRF5 and NF-kB Signaling Pathways

Toll like receptor (TLR)s have a central role in regulating innate immunity and their activation have been highlighted in the pathogenesis of rheumatoid arthritis (RA). EFL2, one of diterpenoids derived from Euphorbia seeds, is nearly unknown expect for its improving effect on acute lung injury. Our...

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Bibliographic Details
Main Authors: Jing Tang, Xiaolan Cheng, Shiyu Yi, Yuanyuan Zhang, Zhigang Tang, Yutong Zhong, Qiuping Zhang, Bin Pan, Yubin Luo
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
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Online Access:https://doaj.org/article/3fede43a673f4bdd8e00ddd84eef76c5
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