G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer

SPOP functions as a tumour suppressor in prostate cancer but how the protein is regulated is unclear. Here, the authors identify G3BP1 as a competitive inhibitor of SPOP and show that G3BP1-SPOP axis activates androgen signalling to drive tumorigenesis.

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Autores principales:	Chandrani Mukhopadhyay, Chenyi Yang, Limei Xu, Deli Liu, Yu Wang, Dennis Huang, Lesa Dayal Deonarine, Joanna Cyrta, Elai Davicioni, Andrea Sboner, Brian. D. Robinson, Arul M. Chinnaiyan, Mark A. Rubin, Christopher E. Barbieri, Pengbo Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3fedf5b03c0240298b8eebd7424bc58a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:3fedf5b03c0240298b8eebd7424bc58a2021-11-21T12:35:52ZG3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer10.1038/s41467-021-27024-x2041-1723https://doaj.org/article/3fedf5b03c0240298b8eebd7424bc58a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27024-xhttps://doaj.org/toc/2041-1723SPOP functions as a tumour suppressor in prostate cancer but how the protein is regulated is unclear. Here, the authors identify G3BP1 as a competitive inhibitor of SPOP and show that G3BP1-SPOP axis activates androgen signalling to drive tumorigenesis.Chandrani MukhopadhyayChenyi YangLimei XuDeli LiuYu WangDennis HuangLesa Dayal DeonarineJoanna CyrtaElai DavicioniAndrea SbonerBrian. D. RobinsonArul M. ChinnaiyanMark A. RubinChristopher E. BarbieriPengbo ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chandrani Mukhopadhyay Chenyi Yang Limei Xu Deli Liu Yu Wang Dennis Huang Lesa Dayal Deonarine Joanna Cyrta Elai Davicioni Andrea Sboner Brian. D. Robinson Arul M. Chinnaiyan Mark A. Rubin Christopher E. Barbieri Pengbo Zhou G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer
description	SPOP functions as a tumour suppressor in prostate cancer but how the protein is regulated is unclear. Here, the authors identify G3BP1 as a competitive inhibitor of SPOP and show that G3BP1-SPOP axis activates androgen signalling to drive tumorigenesis.
format	article
author	Chandrani Mukhopadhyay Chenyi Yang Limei Xu Deli Liu Yu Wang Dennis Huang Lesa Dayal Deonarine Joanna Cyrta Elai Davicioni Andrea Sboner Brian. D. Robinson Arul M. Chinnaiyan Mark A. Rubin Christopher E. Barbieri Pengbo Zhou
author_facet	Chandrani Mukhopadhyay Chenyi Yang Limei Xu Deli Liu Yu Wang Dennis Huang Lesa Dayal Deonarine Joanna Cyrta Elai Davicioni Andrea Sboner Brian. D. Robinson Arul M. Chinnaiyan Mark A. Rubin Christopher E. Barbieri Pengbo Zhou
author_sort	Chandrani Mukhopadhyay
title	G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer
title_short	G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer
title_full	G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer
title_fullStr	G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer
title_full_unstemmed	G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer
title_sort	g3bp1 inhibits cul3spop to amplify ar signaling and promote prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3fedf5b03c0240298b8eebd7424bc58a
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G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer

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