Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges

What if a new technology based on therapeutic deep eutectic systems would disrupt the current treatment of major economic and socially burden diseases? The classical definition of eutectic systems is that they are the combination of two or more compounds that interact via hydrogen bonds, from which...

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Autores principales:	Filipe Oliveira, Filipa Santos, Ana Rita C. Duarte
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	therapeutic deep eutectic systems active pharmaceutical ingredient tuberculosis colorectal cancer drug delivery Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/3ff970f3958749649a8456168bd53b08
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spelling	oai:doaj.org-article:3ff970f3958749649a8456168bd53b082021-11-25T18:29:15ZTherapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges10.3390/molecules262270221420-3049https://doaj.org/article/3ff970f3958749649a8456168bd53b082021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/7022https://doaj.org/toc/1420-3049What if a new technology based on therapeutic deep eutectic systems would disrupt the current treatment of major economic and socially burden diseases? The classical definition of eutectic systems is that they are the combination of two or more compounds that interact via hydrogen bonds, from which results a melting temperature depression in comparison with that of its individual components. Therapeutic deep eutectic systems are defined as eutectic systems in which at least one of the individual components is an active pharmaceutical ingredient, or a eutectic system in which the active pharmaceutical ingredient is dissolved. Current literature reports on tuberculosis have been mostly based on the most common anti-tuberculosis drugs prescribed. Using eutectic systems based on naturally occurring molecules known for their anti-microbial activity may also present a promising therapeutic strategy able to cope with the prevalence of <i>Mycobacterium tuberculosis</i> and prevent the appearance of multidrug resistance strains. With regards to colorectal cancer, literature has been unravelling combinations of terpenes with anti-inflammatory drugs that are selectively cytotoxic towards colorectal cancer cells and do not compromise the viability of normal intestinal cells. This technology could contribute to preventing tumor growth and metastasis while providing a patient compliance therapeutics, which will be crucial to the success of overcoming the challenges presented by cancers.Filipe OliveiraFilipa SantosAna Rita C. DuarteMDPI AGarticletherapeutic deep eutectic systemsactive pharmaceutical ingredienttuberculosiscolorectal cancerdrug deliveryOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 7022, p 7022 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	therapeutic deep eutectic systems active pharmaceutical ingredient tuberculosis colorectal cancer drug delivery Organic chemistry QD241-441
spellingShingle	therapeutic deep eutectic systems active pharmaceutical ingredient tuberculosis colorectal cancer drug delivery Organic chemistry QD241-441 Filipe Oliveira Filipa Santos Ana Rita C. Duarte Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges
description	What if a new technology based on therapeutic deep eutectic systems would disrupt the current treatment of major economic and socially burden diseases? The classical definition of eutectic systems is that they are the combination of two or more compounds that interact via hydrogen bonds, from which results a melting temperature depression in comparison with that of its individual components. Therapeutic deep eutectic systems are defined as eutectic systems in which at least one of the individual components is an active pharmaceutical ingredient, or a eutectic system in which the active pharmaceutical ingredient is dissolved. Current literature reports on tuberculosis have been mostly based on the most common anti-tuberculosis drugs prescribed. Using eutectic systems based on naturally occurring molecules known for their anti-microbial activity may also present a promising therapeutic strategy able to cope with the prevalence of <i>Mycobacterium tuberculosis</i> and prevent the appearance of multidrug resistance strains. With regards to colorectal cancer, literature has been unravelling combinations of terpenes with anti-inflammatory drugs that are selectively cytotoxic towards colorectal cancer cells and do not compromise the viability of normal intestinal cells. This technology could contribute to preventing tumor growth and metastasis while providing a patient compliance therapeutics, which will be crucial to the success of overcoming the challenges presented by cancers.
format	article
author	Filipe Oliveira Filipa Santos Ana Rita C. Duarte
author_facet	Filipe Oliveira Filipa Santos Ana Rita C. Duarte
author_sort	Filipe Oliveira
title	Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges
title_short	Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges
title_full	Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges
title_fullStr	Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges
title_full_unstemmed	Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges
title_sort	therapeutic deep eutectic systems towards the treatment of tuberculosis and colorectal cancer: opportunities and challenges
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3ff970f3958749649a8456168bd53b08
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Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges

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