Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death

Abstract Long-standing clinical findings report a dramatic surge of vasopressin in umbilical cord blood of the human neonate, but the neural underpinnings and function(s) of this phenomenon remain obscure. We studied neural activation in perinatal mice and rats, and found that birth triggers activat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yarely C. Hoffiz, Alexandra Castillo-Ruiz, Megan A. L. Hall, Taylor A. Hite, Jennifer M. Gray, Carla D. Cisternas, Laura R. Cortes, Andrew J. Jacobs, Nancy G. Forger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ffec8c8a6a547f1966ab65d7e48170b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3ffec8c8a6a547f1966ab65d7e48170b
record_format	dspace
spelling	oai:doaj.org-article:3ffec8c8a6a547f1966ab65d7e48170b2021-12-02T13:57:58ZBirth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death10.1038/s41598-021-81511-12045-2322https://doaj.org/article/3ffec8c8a6a547f1966ab65d7e48170b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81511-1https://doaj.org/toc/2045-2322Abstract Long-standing clinical findings report a dramatic surge of vasopressin in umbilical cord blood of the human neonate, but the neural underpinnings and function(s) of this phenomenon remain obscure. We studied neural activation in perinatal mice and rats, and found that birth triggers activation of the suprachiasmatic, supraoptic, and paraventricular nuclei of the hypothalamus. This was seen whether mice were born vaginally or via Cesarean section (C-section), and when birth timing was experimentally manipulated. Neuronal phenotyping showed that the activated neurons were predominantly vasopressinergic, and vasopressin mRNA increased fivefold in the hypothalamus during the 2–3 days before birth. Copeptin, a surrogate marker of vasopressin, was elevated 30-to 50-fold in plasma of perinatal mice, with higher levels after a vaginal than a C-section birth. We also found an acute decrease in plasma osmolality after a vaginal, but not C-section birth, suggesting that the difference in vasopressin release between birth modes is functionally meaningful. When vasopressin was administered centrally to newborns, we found an ~ 50% reduction in neuronal cell death in specific brain areas. Collectively, our results identify a conserved neuroendocrine response to birth that is sensitive to birth mode, and influences peripheral physiology and neurodevelopment.Yarely C. HoffizAlexandra Castillo-RuizMegan A. L. HallTaylor A. HiteJennifer M. GrayCarla D. CisternasLaura R. CortesAndrew J. JacobsNancy G. ForgerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yarely C. Hoffiz Alexandra Castillo-Ruiz Megan A. L. Hall Taylor A. Hite Jennifer M. Gray Carla D. Cisternas Laura R. Cortes Andrew J. Jacobs Nancy G. Forger Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
description	Abstract Long-standing clinical findings report a dramatic surge of vasopressin in umbilical cord blood of the human neonate, but the neural underpinnings and function(s) of this phenomenon remain obscure. We studied neural activation in perinatal mice and rats, and found that birth triggers activation of the suprachiasmatic, supraoptic, and paraventricular nuclei of the hypothalamus. This was seen whether mice were born vaginally or via Cesarean section (C-section), and when birth timing was experimentally manipulated. Neuronal phenotyping showed that the activated neurons were predominantly vasopressinergic, and vasopressin mRNA increased fivefold in the hypothalamus during the 2–3 days before birth. Copeptin, a surrogate marker of vasopressin, was elevated 30-to 50-fold in plasma of perinatal mice, with higher levels after a vaginal than a C-section birth. We also found an acute decrease in plasma osmolality after a vaginal, but not C-section birth, suggesting that the difference in vasopressin release between birth modes is functionally meaningful. When vasopressin was administered centrally to newborns, we found an ~ 50% reduction in neuronal cell death in specific brain areas. Collectively, our results identify a conserved neuroendocrine response to birth that is sensitive to birth mode, and influences peripheral physiology and neurodevelopment.
format	article
author	Yarely C. Hoffiz Alexandra Castillo-Ruiz Megan A. L. Hall Taylor A. Hite Jennifer M. Gray Carla D. Cisternas Laura R. Cortes Andrew J. Jacobs Nancy G. Forger
author_facet	Yarely C. Hoffiz Alexandra Castillo-Ruiz Megan A. L. Hall Taylor A. Hite Jennifer M. Gray Carla D. Cisternas Laura R. Cortes Andrew J. Jacobs Nancy G. Forger
author_sort	Yarely C. Hoffiz
title	Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_short	Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_full	Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_fullStr	Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_full_unstemmed	Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_sort	birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ffec8c8a6a547f1966ab65d7e48170b
work_keys_str_mv	AT yarelychoffiz birthelicitsaconservedneuroendocrineresponsewithimplicationsforperinatalosmoregulationandneuronalcelldeath AT alexandracastilloruiz birthelicitsaconservedneuroendocrineresponsewithimplicationsforperinatalosmoregulationandneuronalcelldeath AT meganalhall birthelicitsaconservedneuroendocrineresponsewithimplicationsforperinatalosmoregulationandneuronalcelldeath AT taylorahite birthelicitsaconservedneuroendocrineresponsewithimplicationsforperinatalosmoregulationandneuronalcelldeath AT jennifermgray birthelicitsaconservedneuroendocrineresponsewithimplicationsforperinatalosmoregulationandneuronalcelldeath AT carladcisternas birthelicitsaconservedneuroendocrineresponsewithimplicationsforperinatalosmoregulationandneuronalcelldeath AT laurarcortes birthelicitsaconservedneuroendocrineresponsewithimplicationsforperinatalosmoregulationandneuronalcelldeath AT andrewjjacobs birthelicitsaconservedneuroendocrineresponsewithimplicationsforperinatalosmoregulationandneuronalcelldeath AT nancygforger birthelicitsaconservedneuroendocrineresponsewithimplicationsforperinatalosmoregulationandneuronalcelldeath
_version_	1718392255430000640

Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death

Ejemplares similares