CYCLIN D1 PROTEIN EXPRESSION IN VARIOUS GRADES OF SALIVARY MUCOEPIDERMOID CARCINOMA

Objective: To assess the expression of Cyclin D1 in Mucoepidermoid Carcinoma (MEC) and its association with various histological grades. Study Design: Case series. Place and Duration of Study: AFIP Rawalpindi, from Nov 2017 to Apr 2018. Material and Methods: A total of 30 cases of MEC were...

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Autores principales:	Saadia Muneer Malik, Zainab Niazi, Mehreen Ali Khan, Shoain Naiyyar Hashmi
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	cyclin d1 mucoepidermoid carcinoma (mec) Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/40007560fc8f43a28becd88c5e5bd356
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spelling	oai:doaj.org-article:40007560fc8f43a28becd88c5e5bd3562021-11-11T05:35:21ZCYCLIN D1 PROTEIN EXPRESSION IN VARIOUS GRADES OF SALIVARY MUCOEPIDERMOID CARCINOMA0030-96482411-8842https://doaj.org/article/40007560fc8f43a28becd88c5e5bd3562019-08-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3225/2333https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To assess the expression of Cyclin D1 in Mucoepidermoid Carcinoma (MEC) and its association with various histological grades. Study Design: Case series. Place and Duration of Study: AFIP Rawalpindi, from Nov 2017 to Apr 2018. Material and Methods: A total of 30 cases of MEC were included in this study. Paraffin embedded blocks of patients of both genders, diagnosed with salivary gland mucoepidermoid carcinoma were included as experimental samples while necrotic, scarce and autolysed cases were not included. Tumor was graded as per the grading criteria of Auclair et al. Cyclin D1 was applied and the results were analyzed using chi-square test. Results: Of the 30 selected cases, 21 (70%) were male and 9 (30%) were female patients. According to histological grades, 14 (46.67%) comprised of low grade, 06 (20%) intermediate grade and 10 (33.34%) high grade tumors. Among these cases 6 (20%) were positive and 24 (80%) had altered results. In low grade MEC all 14 (0%) cases had negative results and none was positive. Among the 6 intermediate grade cases 3 (50%) showed positive and 3 (50%) showed altered expression and in high grade tumors 7 (70%) out of 10 had altered results and 3 (30%) showed positive results. A significant association (p-value=0.02) was seen between expression of Cyclin D1 and grades of MEC. Conclusion: A significant association was seen between Cyclin D1 expression and grades of MEC (p=0.02). Cyclin d1 showed an increase in expression with increase in grade of tumor. Hence it can serve as a potential marker for grading of mucoepidermoid carcinoma.Saadia Muneer MalikZainab NiaziMehreen Ali KhanShoain Naiyyar HashmiArmy Medical College Rawalpindiarticlecyclin d1mucoepidermoid carcinoma (mec)MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 4, Pp 920-925 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	cyclin d1 mucoepidermoid carcinoma (mec) Medicine R Medicine (General) R5-920
spellingShingle	cyclin d1 mucoepidermoid carcinoma (mec) Medicine R Medicine (General) R5-920 Saadia Muneer Malik Zainab Niazi Mehreen Ali Khan Shoain Naiyyar Hashmi CYCLIN D1 PROTEIN EXPRESSION IN VARIOUS GRADES OF SALIVARY MUCOEPIDERMOID CARCINOMA
description	Objective: To assess the expression of Cyclin D1 in Mucoepidermoid Carcinoma (MEC) and its association with various histological grades. Study Design: Case series. Place and Duration of Study: AFIP Rawalpindi, from Nov 2017 to Apr 2018. Material and Methods: A total of 30 cases of MEC were included in this study. Paraffin embedded blocks of patients of both genders, diagnosed with salivary gland mucoepidermoid carcinoma were included as experimental samples while necrotic, scarce and autolysed cases were not included. Tumor was graded as per the grading criteria of Auclair et al. Cyclin D1 was applied and the results were analyzed using chi-square test. Results: Of the 30 selected cases, 21 (70%) were male and 9 (30%) were female patients. According to histological grades, 14 (46.67%) comprised of low grade, 06 (20%) intermediate grade and 10 (33.34%) high grade tumors. Among these cases 6 (20%) were positive and 24 (80%) had altered results. In low grade MEC all 14 (0%) cases had negative results and none was positive. Among the 6 intermediate grade cases 3 (50%) showed positive and 3 (50%) showed altered expression and in high grade tumors 7 (70%) out of 10 had altered results and 3 (30%) showed positive results. A significant association (p-value=0.02) was seen between expression of Cyclin D1 and grades of MEC. Conclusion: A significant association was seen between Cyclin D1 expression and grades of MEC (p=0.02). Cyclin d1 showed an increase in expression with increase in grade of tumor. Hence it can serve as a potential marker for grading of mucoepidermoid carcinoma.
format	article
author	Saadia Muneer Malik Zainab Niazi Mehreen Ali Khan Shoain Naiyyar Hashmi
author_facet	Saadia Muneer Malik Zainab Niazi Mehreen Ali Khan Shoain Naiyyar Hashmi
author_sort	Saadia Muneer Malik
title	CYCLIN D1 PROTEIN EXPRESSION IN VARIOUS GRADES OF SALIVARY MUCOEPIDERMOID CARCINOMA
title_short	CYCLIN D1 PROTEIN EXPRESSION IN VARIOUS GRADES OF SALIVARY MUCOEPIDERMOID CARCINOMA
title_full	CYCLIN D1 PROTEIN EXPRESSION IN VARIOUS GRADES OF SALIVARY MUCOEPIDERMOID CARCINOMA
title_fullStr	CYCLIN D1 PROTEIN EXPRESSION IN VARIOUS GRADES OF SALIVARY MUCOEPIDERMOID CARCINOMA
title_full_unstemmed	CYCLIN D1 PROTEIN EXPRESSION IN VARIOUS GRADES OF SALIVARY MUCOEPIDERMOID CARCINOMA
title_sort	cyclin d1 protein expression in various grades of salivary mucoepidermoid carcinoma
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/40007560fc8f43a28becd88c5e5bd356
work_keys_str_mv	AT saadiamuneermalik cyclind1proteinexpressioninvariousgradesofsalivarymucoepidermoidcarcinoma AT zainabniazi cyclind1proteinexpressioninvariousgradesofsalivarymucoepidermoidcarcinoma AT mehreenalikhan cyclind1proteinexpressioninvariousgradesofsalivarymucoepidermoidcarcinoma AT shoainnaiyyarhashmi cyclind1proteinexpressioninvariousgradesofsalivarymucoepidermoidcarcinoma
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CYCLIN D1 PROTEIN EXPRESSION IN VARIOUS GRADES OF SALIVARY MUCOEPIDERMOID CARCINOMA

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