Anxiety disorders therapy in general practice

Anxiety disorders among general practice patients are the most common. We examined the efficacy and safety of Buspirone in patients with anxiety disorders in outpatient practice. In accordance with lCD-10, the patients were distributed as follows: generalized anxiety disorder - 38.7 %, panic disorde...

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Autor principal:	L. A. Ivanova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	anxiety disorders buspirone Science Q
Acceso en línea:	https://doaj.org/article/40027748423c4d55b5d4588c4dcf8d5c
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spelling	oai:doaj.org-article:40027748423c4d55b5d4588c4dcf8d5c2021-11-23T06:14:38ZAnxiety disorders therapy in general practice2541-94202587-959610.12737/article_5a3a0e7b6a3885.64967546https://doaj.org/article/40027748423c4d55b5d4588c4dcf8d5c2017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/519https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Anxiety disorders among general practice patients are the most common. We examined the efficacy and safety of Buspirone in patients with anxiety disorders in outpatient practice. In accordance with lCD-10, the patients were distributed as follows: generalized anxiety disorder - 38.7 %, panic disorder - 29 %, adjustment disorder in the form of mixed depressive and anxiety reaction - 32.3 %. In order to evaluate the impact of therapy the following research methods were used: clinical, clinical-psychopathological, psychometric (Hamilton anxiety scale (HaM-А), Spielberger-Hanin anxiety level self-evaluation scale, Shihan anxiety self-evaluation scale, Clinical Global lmpression-Severity Scale (CGl-S), and Clinical Global Impression of Improvement (CGl-l) Scale. Among patients with anxiety disorders 28 people (90.3 %) have finished the study, three persons (9.7 %) dropped out of the study with regard to the ineffectiveness of Buspirone therapy. Analysis of the values on the HAM-А scale revealed statistically significant reduction in composite score by the end of day 14 (by 23.4 %, p < 0.05) and a statistically significant increase in differences by day 35 of therapy and reduction of scores by 51.5 % (p < 0.01). A statistically significant reduction (by 21.9 %, p < 0.05) of points on the Shihan anxiety scale was revealed by day 21 of therapy. Reduction of the mean values of the total score of reactive and personal anxiety by the Spielberger - Hanin scale was recorded from day 21 of therapy (p < 0.05). CGl-S scale statistically reliable reduction of patients with moderate degree of severity to 26.6 % (p < 0.05) and a statistically significant increase in the number of patients with mild degrees of severity by 20 % (p < 0.05) were revealed on day 14 of therapy. On the CGl-l scale, a marked improvement (26.7 %, p < 0.05) and a slight improvement (33.3 %, p < 0.05) is achieved by day 14 of therapy. Undesirable effects in the form of motor coordination disturbance, drowsiness, dizziness leveled during the therapy and did not require additional prescriptions for their correction. Buspirone can be recommended as an effective anxiolytic drug with safe portability profile for the treatment of anxiety disorders.L. A. IvanovaScientific Сentre for Family Health and Human Reproduction Problemsarticleanxiety disordersbuspironeScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(2), Pp 121-124 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	anxiety disorders buspirone Science Q
spellingShingle	anxiety disorders buspirone Science Q L. A. Ivanova Anxiety disorders therapy in general practice
description	Anxiety disorders among general practice patients are the most common. We examined the efficacy and safety of Buspirone in patients with anxiety disorders in outpatient practice. In accordance with lCD-10, the patients were distributed as follows: generalized anxiety disorder - 38.7 %, panic disorder - 29 %, adjustment disorder in the form of mixed depressive and anxiety reaction - 32.3 %. In order to evaluate the impact of therapy the following research methods were used: clinical, clinical-psychopathological, psychometric (Hamilton anxiety scale (HaM-А), Spielberger-Hanin anxiety level self-evaluation scale, Shihan anxiety self-evaluation scale, Clinical Global lmpression-Severity Scale (CGl-S), and Clinical Global Impression of Improvement (CGl-l) Scale. Among patients with anxiety disorders 28 people (90.3 %) have finished the study, three persons (9.7 %) dropped out of the study with regard to the ineffectiveness of Buspirone therapy. Analysis of the values on the HAM-А scale revealed statistically significant reduction in composite score by the end of day 14 (by 23.4 %, p < 0.05) and a statistically significant increase in differences by day 35 of therapy and reduction of scores by 51.5 % (p < 0.01). A statistically significant reduction (by 21.9 %, p < 0.05) of points on the Shihan anxiety scale was revealed by day 21 of therapy. Reduction of the mean values of the total score of reactive and personal anxiety by the Spielberger - Hanin scale was recorded from day 21 of therapy (p < 0.05). CGl-S scale statistically reliable reduction of patients with moderate degree of severity to 26.6 % (p < 0.05) and a statistically significant increase in the number of patients with mild degrees of severity by 20 % (p < 0.05) were revealed on day 14 of therapy. On the CGl-l scale, a marked improvement (26.7 %, p < 0.05) and a slight improvement (33.3 %, p < 0.05) is achieved by day 14 of therapy. Undesirable effects in the form of motor coordination disturbance, drowsiness, dizziness leveled during the therapy and did not require additional prescriptions for their correction. Buspirone can be recommended as an effective anxiolytic drug with safe portability profile for the treatment of anxiety disorders.
format	article
author	L. A. Ivanova
author_facet	L. A. Ivanova
author_sort	L. A. Ivanova
title	Anxiety disorders therapy in general practice
title_short	Anxiety disorders therapy in general practice
title_full	Anxiety disorders therapy in general practice
title_fullStr	Anxiety disorders therapy in general practice
title_full_unstemmed	Anxiety disorders therapy in general practice
title_sort	anxiety disorders therapy in general practice
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/40027748423c4d55b5d4588c4dcf8d5c
work_keys_str_mv	AT laivanova anxietydisorderstherapyingeneralpractice
_version_	1718417000720498688

Anxiety disorders therapy in general practice

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