A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide

Abstract There is an urgent need for disinfection and sterilization devices accessible to the public that can be fulfilled by innovative strategies for using cold atmospheric pressure plasmas. Here, we demonstrate a successful novel combination of a flexible printed circuit design of a dielectric ba...

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Autores principales:	Sophia Gershman, Maria B. Harreguy, Shurik Yatom, Yevgeny Raitses, Phillip Efthimion, Gal Haspel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4002af737b1f4778b16386699271bc39
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spelling	oai:doaj.org-article:4002af737b1f4778b16386699271bc392021-12-02T13:35:03ZA low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide10.1038/s41598-021-84086-z2045-2322https://doaj.org/article/4002af737b1f4778b16386699271bc392021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84086-zhttps://doaj.org/toc/2045-2322Abstract There is an urgent need for disinfection and sterilization devices accessible to the public that can be fulfilled by innovative strategies for using cold atmospheric pressure plasmas. Here, we demonstrate a successful novel combination of a flexible printed circuit design of a dielectric barrier discharge (flex-DBD) with an environmentally safe chemical reagent for surface decontamination from bacterial contaminants. Flex-DBD operates in ambient air, atmospheric pressure, and room temperature without any additional gas flow at a power density not exceeding 0.5 W/cm2. The flex-DBD activation of a 3% hydrogen peroxide solution results in the reduction in the bacterial load of a surface contaminant of > 6log10 in 90 s, about 3log10 and 2log10 better than hydrogen peroxide alone or the flex-DBD alone, respectively, for the same treatment time. We propose that the synergy between plasma and hydrogen peroxide is based on the combined action of plasma-generated OH · radicals in the hydrogen peroxide solution and the reactive nitrogen species supplied by the plasma effluent. A scavenger method verified a significant increase in OH · concentration due to plasma treatment. Novel in-situ FTIR absorption spectra show the presence of O3, NO2, N2O, and other nitrogen species. Ozone dissolving in the H2O2 solution can effectively generate OH · through a peroxone process. The addition of the reactive nitrogen species increases the disinfection efficiency of the hydroxyl radicals and other oxygen species. Hence, plasma activation of a low concentration hydrogen peroxide solution, using a hand-held flexible DBD device results in a dramatic improvement in disinfection.Sophia GershmanMaria B. HarreguyShurik YatomYevgeny RaitsesPhillip EfthimionGal HaspelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sophia Gershman Maria B. Harreguy Shurik Yatom Yevgeny Raitses Phillip Efthimion Gal Haspel A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
description	Abstract There is an urgent need for disinfection and sterilization devices accessible to the public that can be fulfilled by innovative strategies for using cold atmospheric pressure plasmas. Here, we demonstrate a successful novel combination of a flexible printed circuit design of a dielectric barrier discharge (flex-DBD) with an environmentally safe chemical reagent for surface decontamination from bacterial contaminants. Flex-DBD operates in ambient air, atmospheric pressure, and room temperature without any additional gas flow at a power density not exceeding 0.5 W/cm2. The flex-DBD activation of a 3% hydrogen peroxide solution results in the reduction in the bacterial load of a surface contaminant of > 6log10 in 90 s, about 3log10 and 2log10 better than hydrogen peroxide alone or the flex-DBD alone, respectively, for the same treatment time. We propose that the synergy between plasma and hydrogen peroxide is based on the combined action of plasma-generated OH · radicals in the hydrogen peroxide solution and the reactive nitrogen species supplied by the plasma effluent. A scavenger method verified a significant increase in OH · concentration due to plasma treatment. Novel in-situ FTIR absorption spectra show the presence of O3, NO2, N2O, and other nitrogen species. Ozone dissolving in the H2O2 solution can effectively generate OH · through a peroxone process. The addition of the reactive nitrogen species increases the disinfection efficiency of the hydroxyl radicals and other oxygen species. Hence, plasma activation of a low concentration hydrogen peroxide solution, using a hand-held flexible DBD device results in a dramatic improvement in disinfection.
format	article
author	Sophia Gershman Maria B. Harreguy Shurik Yatom Yevgeny Raitses Phillip Efthimion Gal Haspel
author_facet	Sophia Gershman Maria B. Harreguy Shurik Yatom Yevgeny Raitses Phillip Efthimion Gal Haspel
author_sort	Sophia Gershman
title	A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
title_short	A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
title_full	A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
title_fullStr	A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
title_full_unstemmed	A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
title_sort	low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4002af737b1f4778b16386699271bc39
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A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide

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