Interferon mediated prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine lacking non-structural protein 1

Interferon mediated prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine lacking non-structural protein 1

Abstract The influenza A non-structural protein 1 (NS1) is known for its ability to hinder the synthesis of type I interferon (IFN) during viral infection. Influenza viruses lacking NS1 (ΔNS1) are under clinical development as live attenuated human influenza virus vaccines and induce potent influenz...

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Autores principales: Raveen Rathnasinghe, Mirella Salvatore, Hongyong Zheng, Sonia Jangra, Thomas Kehrer, Ignacio Mena, Michael Schotsaert, Thomas Muster, Peter Palese, Adolfo García-Sastre
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/40093ba6def04ffd8471e4167f233f58
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