No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses

Abstract The genetic element s2m has been acquired through horizontal transfer by many distantly related viruses, including the SARS-related coronaviruses. Here we show that s2m is evolutionarily conserved in these viruses. Though several lineages of severe acute respiratory syndrome coronavirus 2 (...

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Autores principales:	Clément Gilbert, Torstein Tengs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/400af4b6f37f43678f48659141394df5
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spelling	oai:doaj.org-article:400af4b6f37f43678f48659141394df52021-12-02T16:28:06ZNo species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses10.1038/s41598-021-95496-42045-2322https://doaj.org/article/400af4b6f37f43678f48659141394df52021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95496-4https://doaj.org/toc/2045-2322Abstract The genetic element s2m has been acquired through horizontal transfer by many distantly related viruses, including the SARS-related coronaviruses. Here we show that s2m is evolutionarily conserved in these viruses. Though several lineages of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) devoid of the element can be found, these variants seem to have been short lived, indicating that they were less evolutionary fit than their s2m-containing counterparts. On a species-level, however, there do not appear to be any losses and this pattern strongly suggests that the s2m element is essential to virus replication in SARS-CoV-2 and related viruses. Further experiments are needed to elucidate the function of s2m.Clément GilbertTorstein TengsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clément Gilbert Torstein Tengs No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
description	Abstract The genetic element s2m has been acquired through horizontal transfer by many distantly related viruses, including the SARS-related coronaviruses. Here we show that s2m is evolutionarily conserved in these viruses. Though several lineages of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) devoid of the element can be found, these variants seem to have been short lived, indicating that they were less evolutionary fit than their s2m-containing counterparts. On a species-level, however, there do not appear to be any losses and this pattern strongly suggests that the s2m element is essential to virus replication in SARS-CoV-2 and related viruses. Further experiments are needed to elucidate the function of s2m.
format	article
author	Clément Gilbert Torstein Tengs
author_facet	Clément Gilbert Torstein Tengs
author_sort	Clément Gilbert
title	No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
title_short	No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
title_full	No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
title_fullStr	No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
title_full_unstemmed	No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
title_sort	no species-level losses of s2m suggests critical role in replication of sars-related coronaviruses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/400af4b6f37f43678f48659141394df5
work_keys_str_mv	AT clementgilbert nospecieslevellossesofs2msuggestscriticalroleinreplicationofsarsrelatedcoronaviruses AT torsteintengs nospecieslevellossesofs2msuggestscriticalroleinreplicationofsarsrelatedcoronaviruses
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No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses

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