B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms

Heather L Wilson1,21Vaccine and Infectious Disease Organization-International Vaccine Center, 2Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaAbstract: For many years, central dogma defined multiple sclerosis (MS) as a T cell-driven autoimmune disorder; howeve...

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Autor principal:	Wilson HL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/400d9164ef974cdf94417d89ef0858e3
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spelling	oai:doaj.org-article:400d9164ef974cdf94417d89ef0858e32021-12-02T07:18:40ZB cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms1177-54751177-5491https://doaj.org/article/400d9164ef974cdf94417d89ef0858e32012-05-01T00:00:00Zhttp://www.dovepress.com/b-cells-contribute-to-ms-pathogenesis-through-antibody-dependent-and-a-a9833https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Heather L Wilson1,21Vaccine and Infectious Disease Organization-International Vaccine Center, 2Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaAbstract: For many years, central dogma defined multiple sclerosis (MS) as a T cell-driven autoimmune disorder; however, over the past decade there has been a burgeoning recognition that B cells contribute to the pathogenesis of certain MS disease subtypes. B cells may contribute to MS pathogenesis through production of autoantibodies (or antibodies directed at foreign bodies, which unfortunately cross-react with self-antigens), through promotion of T cell activation via antigen presentation, or through production of cytokines. This review highlights evidence for antibody-dependent and antibody-independent B cell involvement in MS pathogenesis.Keywords: autoantibodies, antibody targets, clinically isolated MS, primary progressive MS, secondary progressive MS, relapsing and remitting MS, T cells, T regulatory cellsWilson HLDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2012, Iss default, Pp 117-123 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wilson HL B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms
description	Heather L Wilson1,21Vaccine and Infectious Disease Organization-International Vaccine Center, 2Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaAbstract: For many years, central dogma defined multiple sclerosis (MS) as a T cell-driven autoimmune disorder; however, over the past decade there has been a burgeoning recognition that B cells contribute to the pathogenesis of certain MS disease subtypes. B cells may contribute to MS pathogenesis through production of autoantibodies (or antibodies directed at foreign bodies, which unfortunately cross-react with self-antigens), through promotion of T cell activation via antigen presentation, or through production of cytokines. This review highlights evidence for antibody-dependent and antibody-independent B cell involvement in MS pathogenesis.Keywords: autoantibodies, antibody targets, clinically isolated MS, primary progressive MS, secondary progressive MS, relapsing and remitting MS, T cells, T regulatory cells
format	article
author	Wilson HL
author_facet	Wilson HL
author_sort	Wilson HL
title	B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms
title_short	B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms
title_full	B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms
title_fullStr	B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms
title_full_unstemmed	B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms
title_sort	b cells contribute to ms pathogenesis through antibody-dependent and antibody-independent mechanisms
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/400d9164ef974cdf94417d89ef0858e3
work_keys_str_mv	AT wilsonhl bcellscontributetomspathogenesisthroughantibodydependentandantibodyindependentmechanisms
_version_	1718399513258885120

B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms

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