The Bioactive Compound and Mechanism of Action of Sea Cucumber (Holothuridae) as Anticancer: A Review

The extreme development and resistance towards cancer drugs, and also the high toxicity, drug resistense and side effects of some cancer chemotherapy drug triggers us to develop new drugs as one of the alternative substitutes or combinations of cancer drugs, one of the resources come frome marine bi...

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Autores principales:	Diah Anggraini Wulandari, Gita Syahputra, Masteria Yunovilsa Putra
Formato:	article
Lenguaje:	EN
Publicado:	University of Brawijaya 2020
Materias:	anticancer bioprospecting holothuridae mechanism of action sea cucumber Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/400ee447ade14ecfa2f8fd402a1055a3
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spelling	oai:doaj.org-article:400ee447ade14ecfa2f8fd402a1055a32021-11-10T06:20:29ZThe Bioactive Compound and Mechanism of Action of Sea Cucumber (Holothuridae) as Anticancer: A Review2302-46902541-0733https://doaj.org/article/400ee447ade14ecfa2f8fd402a1055a32020-11-01T00:00:00Zhttps://jpacr.ub.ac.id/index.php/jpacr/article/view/534/pdfhttps://doaj.org/toc/2302-4690https://doaj.org/toc/2541-0733The extreme development and resistance towards cancer drugs, and also the high toxicity, drug resistense and side effects of some cancer chemotherapy drug triggers us to develop new drugs as one of the alternative substitutes or combinations of cancer drugs, one of the resources come frome marine biodiversity especially sea cucumber. The bioactive compound from sea cucumber can inhibit cencer cell growth with the various mechanism. This study aims to analyze chemichal composition, bioactive compound from sea cucumber to inhibit cancer cell line and to analyze mechanism of action of sea cucumber as anticancer wih the most recent research studies. The result shows sea cucumber contained protein 44-82%, amino acid, fatty acid, collagen, peptide, micro essential. Each sea cucumber species produce the different secondary metabolites that can use as anticancer. Sea cucumbers contain triterpene glycosides, saponins, Holothurin A, sti-choposides, frondoside, cucumariosides, Dsechinoside, fucoidan, triterpenoid aglycones (philinopgeni), non-glycosaminoglycan, sulfated glycans, sulfated polysacchidides,non-glycosaminosides) that can inhibit cancer cell line. That bioactive compound had a various mechanism such as apoptosis in cell line and mitocondria, Antioksidan mechanism,and membranolitic.Diah Anggraini WulandariGita SyahputraMasteria Yunovilsa PutraUniversity of Brawijayaarticleanticancerbioprospectingholothuridaemechanism of actionsea cucumberChemistryQD1-999ENJournal of Pure and Applied Chemistry Research, Vol 09, Iss 3, Pp 153-170 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	anticancer bioprospecting holothuridae mechanism of action sea cucumber Chemistry QD1-999
spellingShingle	anticancer bioprospecting holothuridae mechanism of action sea cucumber Chemistry QD1-999 Diah Anggraini Wulandari Gita Syahputra Masteria Yunovilsa Putra The Bioactive Compound and Mechanism of Action of Sea Cucumber (Holothuridae) as Anticancer: A Review
description	The extreme development and resistance towards cancer drugs, and also the high toxicity, drug resistense and side effects of some cancer chemotherapy drug triggers us to develop new drugs as one of the alternative substitutes or combinations of cancer drugs, one of the resources come frome marine biodiversity especially sea cucumber. The bioactive compound from sea cucumber can inhibit cencer cell growth with the various mechanism. This study aims to analyze chemichal composition, bioactive compound from sea cucumber to inhibit cancer cell line and to analyze mechanism of action of sea cucumber as anticancer wih the most recent research studies. The result shows sea cucumber contained protein 44-82%, amino acid, fatty acid, collagen, peptide, micro essential. Each sea cucumber species produce the different secondary metabolites that can use as anticancer. Sea cucumbers contain triterpene glycosides, saponins, Holothurin A, sti-choposides, frondoside, cucumariosides, Dsechinoside, fucoidan, triterpenoid aglycones (philinopgeni), non-glycosaminoglycan, sulfated glycans, sulfated polysacchidides,non-glycosaminosides) that can inhibit cancer cell line. That bioactive compound had a various mechanism such as apoptosis in cell line and mitocondria, Antioksidan mechanism,and membranolitic.
format	article
author	Diah Anggraini Wulandari Gita Syahputra Masteria Yunovilsa Putra
author_facet	Diah Anggraini Wulandari Gita Syahputra Masteria Yunovilsa Putra
author_sort	Diah Anggraini Wulandari
title	The Bioactive Compound and Mechanism of Action of Sea Cucumber (Holothuridae) as Anticancer: A Review
title_short	The Bioactive Compound and Mechanism of Action of Sea Cucumber (Holothuridae) as Anticancer: A Review
title_full	The Bioactive Compound and Mechanism of Action of Sea Cucumber (Holothuridae) as Anticancer: A Review
title_fullStr	The Bioactive Compound and Mechanism of Action of Sea Cucumber (Holothuridae) as Anticancer: A Review
title_full_unstemmed	The Bioactive Compound and Mechanism of Action of Sea Cucumber (Holothuridae) as Anticancer: A Review
title_sort	bioactive compound and mechanism of action of sea cucumber (holothuridae) as anticancer: a review
publisher	University of Brawijaya
publishDate	2020
url	https://doaj.org/article/400ee447ade14ecfa2f8fd402a1055a3
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The Bioactive Compound and Mechanism of Action of Sea Cucumber (Holothuridae) as Anticancer: A Review

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