Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth

Changes in glucose metabolism can lead to tumor development, but the involvement of splicing factors is unclear. Here, the authors screened for SR proteins and identified SRSF5 stability is enhanced in response to glucose elevation to promote alternative splicing of CCAR1 which facilitates tumor gro...

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Autores principales:	Yuhan Chen, Qingyang Huang, Wen Liu, Qiong Zhu, Chun-Ping Cui, Liang Xu, Xing Guo, Ping Wang, Jingwen Liu, Guanglong Dong, Wenyi Wei, Cui Hua Liu, Zhichun Feng, Fuchu He, Lingqiang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/400fb7c1b7a24274a07f85d7e3997f10
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spelling	oai:doaj.org-article:400fb7c1b7a24274a07f85d7e3997f102021-12-02T17:33:16ZMutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth10.1038/s41467-018-04815-32041-1723https://doaj.org/article/400fb7c1b7a24274a07f85d7e3997f102018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04815-3https://doaj.org/toc/2041-1723Changes in glucose metabolism can lead to tumor development, but the involvement of splicing factors is unclear. Here, the authors screened for SR proteins and identified SRSF5 stability is enhanced in response to glucose elevation to promote alternative splicing of CCAR1 which facilitates tumor growth.Yuhan ChenQingyang HuangWen LiuQiong ZhuChun-Ping CuiLiang XuXing GuoPing WangJingwen LiuGuanglong DongWenyi WeiCui Hua LiuZhichun FengFuchu HeLingqiang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuhan Chen Qingyang Huang Wen Liu Qiong Zhu Chun-Ping Cui Liang Xu Xing Guo Ping Wang Jingwen Liu Guanglong Dong Wenyi Wei Cui Hua Liu Zhichun Feng Fuchu He Lingqiang Zhang Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth
description	Changes in glucose metabolism can lead to tumor development, but the involvement of splicing factors is unclear. Here, the authors screened for SR proteins and identified SRSF5 stability is enhanced in response to glucose elevation to promote alternative splicing of CCAR1 which facilitates tumor growth.
format	article
author	Yuhan Chen Qingyang Huang Wen Liu Qiong Zhu Chun-Ping Cui Liang Xu Xing Guo Ping Wang Jingwen Liu Guanglong Dong Wenyi Wei Cui Hua Liu Zhichun Feng Fuchu He Lingqiang Zhang
author_facet	Yuhan Chen Qingyang Huang Wen Liu Qiong Zhu Chun-Ping Cui Liang Xu Xing Guo Ping Wang Jingwen Liu Guanglong Dong Wenyi Wei Cui Hua Liu Zhichun Feng Fuchu He Lingqiang Zhang
author_sort	Yuhan Chen
title	Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth
title_short	Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth
title_full	Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth
title_fullStr	Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth
title_full_unstemmed	Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth
title_sort	mutually exclusive acetylation and ubiquitylation of the splicing factor srsf5 control tumor growth
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/400fb7c1b7a24274a07f85d7e3997f10
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Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth

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