Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study
The influence of hypertension and aging alone on brain structure has been described extensively. Our understanding of the interaction of hypertension with aging to brain morphology is still limited. We aimed to detect the synergistic effects of hypertension and aging on brain morphology and to descr...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:4011ce878578437d8f6d16a4905d0ccc2021-12-01T19:47:49ZEvolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study1663-436510.3389/fnagi.2021.757808https://doaj.org/article/4011ce878578437d8f6d16a4905d0ccc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.757808/fullhttps://doaj.org/toc/1663-4365The influence of hypertension and aging alone on brain structure has been described extensively. Our understanding of the interaction of hypertension with aging to brain morphology is still limited. We aimed to detect the synergistic effects of hypertension and aging on brain morphology and to describe the evolution patterns of cerebral atrophy from spatial and temporal perspectives. In 8 spontaneously hypertensive rats (SHRs) and 5 Wistar-Kyoto rats, high-resolution magnetic resonance imaging scans were longitudinally acquired at 10, 24, 52, and 80 weeks. We analyzed the tissue volumes of gray matter, white matter, cerebral spinal fluid, and total intracranial volume (TIV), and then evaluated gray matter volume in detail using voxel-based morphometry (VBM) and region of interest-based methods. There were interactive effects on hypertension and aging in tissue volumes of gray matter, white matter, and TIV, of which gray matter atrophy was most pronounced, especially in elderly SHRs. We identified the vulnerable gray matter volume with combined effects of hypertension and aging in the septal region, bilateral caudate putamen, hippocampus, primary somatosensory cortex, cerebellum, periaqueductal gray, right accumbens nucleus, and thalamus. We automatically extracted the septal region, anterior cingulate cortex, primary somatosensory cortex, caudate putamen, hippocampus, and accumbens nucleus and revealed an inverted-U trajectory of volume change in SHRs, with volume increase at the early phase and decline at the late phase. Hypertension interacts with aging to affect brain volume changes such as severe atrophy in elderly SHRs.Yingying YangYingying YangQuan ZhangJialiang RenQingfeng ZhuLixin WangYongzhi ZhangZuojun GengFrontiers Media S.A.articlehypertensionagingmagnetic resonance imagingvoxel-based morphometrybrain atrophyspontaneously hypertensive ratNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021) |
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hypertension aging magnetic resonance imaging voxel-based morphometry brain atrophy spontaneously hypertensive rat Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
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hypertension aging magnetic resonance imaging voxel-based morphometry brain atrophy spontaneously hypertensive rat Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Yingying Yang Yingying Yang Quan Zhang Jialiang Ren Qingfeng Zhu Lixin Wang Yongzhi Zhang Zuojun Geng Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study |
description |
The influence of hypertension and aging alone on brain structure has been described extensively. Our understanding of the interaction of hypertension with aging to brain morphology is still limited. We aimed to detect the synergistic effects of hypertension and aging on brain morphology and to describe the evolution patterns of cerebral atrophy from spatial and temporal perspectives. In 8 spontaneously hypertensive rats (SHRs) and 5 Wistar-Kyoto rats, high-resolution magnetic resonance imaging scans were longitudinally acquired at 10, 24, 52, and 80 weeks. We analyzed the tissue volumes of gray matter, white matter, cerebral spinal fluid, and total intracranial volume (TIV), and then evaluated gray matter volume in detail using voxel-based morphometry (VBM) and region of interest-based methods. There were interactive effects on hypertension and aging in tissue volumes of gray matter, white matter, and TIV, of which gray matter atrophy was most pronounced, especially in elderly SHRs. We identified the vulnerable gray matter volume with combined effects of hypertension and aging in the septal region, bilateral caudate putamen, hippocampus, primary somatosensory cortex, cerebellum, periaqueductal gray, right accumbens nucleus, and thalamus. We automatically extracted the septal region, anterior cingulate cortex, primary somatosensory cortex, caudate putamen, hippocampus, and accumbens nucleus and revealed an inverted-U trajectory of volume change in SHRs, with volume increase at the early phase and decline at the late phase. Hypertension interacts with aging to affect brain volume changes such as severe atrophy in elderly SHRs. |
format |
article |
author |
Yingying Yang Yingying Yang Quan Zhang Jialiang Ren Qingfeng Zhu Lixin Wang Yongzhi Zhang Zuojun Geng |
author_facet |
Yingying Yang Yingying Yang Quan Zhang Jialiang Ren Qingfeng Zhu Lixin Wang Yongzhi Zhang Zuojun Geng |
author_sort |
Yingying Yang |
title |
Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study |
title_short |
Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study |
title_full |
Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study |
title_fullStr |
Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study |
title_full_unstemmed |
Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study |
title_sort |
evolution of brain morphology in spontaneously hypertensive and wistar-kyoto rats from early adulthood to aging: a longitudinal magnetic resonance imaging study |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doaj.org/article/4011ce878578437d8f6d16a4905d0ccc |
work_keys_str_mv |
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