Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study

The influence of hypertension and aging alone on brain structure has been described extensively. Our understanding of the interaction of hypertension with aging to brain morphology is still limited. We aimed to detect the synergistic effects of hypertension and aging on brain morphology and to descr...

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Autores principales: Yingying Yang, Quan Zhang, Jialiang Ren, Qingfeng Zhu, Lixin Wang, Yongzhi Zhang, Zuojun Geng
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Publicado: Frontiers Media S.A. 2021
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spelling oai:doaj.org-article:4011ce878578437d8f6d16a4905d0ccc2021-12-01T19:47:49ZEvolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study1663-436510.3389/fnagi.2021.757808https://doaj.org/article/4011ce878578437d8f6d16a4905d0ccc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.757808/fullhttps://doaj.org/toc/1663-4365The influence of hypertension and aging alone on brain structure has been described extensively. Our understanding of the interaction of hypertension with aging to brain morphology is still limited. We aimed to detect the synergistic effects of hypertension and aging on brain morphology and to describe the evolution patterns of cerebral atrophy from spatial and temporal perspectives. In 8 spontaneously hypertensive rats (SHRs) and 5 Wistar-Kyoto rats, high-resolution magnetic resonance imaging scans were longitudinally acquired at 10, 24, 52, and 80 weeks. We analyzed the tissue volumes of gray matter, white matter, cerebral spinal fluid, and total intracranial volume (TIV), and then evaluated gray matter volume in detail using voxel-based morphometry (VBM) and region of interest-based methods. There were interactive effects on hypertension and aging in tissue volumes of gray matter, white matter, and TIV, of which gray matter atrophy was most pronounced, especially in elderly SHRs. We identified the vulnerable gray matter volume with combined effects of hypertension and aging in the septal region, bilateral caudate putamen, hippocampus, primary somatosensory cortex, cerebellum, periaqueductal gray, right accumbens nucleus, and thalamus. We automatically extracted the septal region, anterior cingulate cortex, primary somatosensory cortex, caudate putamen, hippocampus, and accumbens nucleus and revealed an inverted-U trajectory of volume change in SHRs, with volume increase at the early phase and decline at the late phase. Hypertension interacts with aging to affect brain volume changes such as severe atrophy in elderly SHRs.Yingying YangYingying YangQuan ZhangJialiang RenQingfeng ZhuLixin WangYongzhi ZhangZuojun GengFrontiers Media S.A.articlehypertensionagingmagnetic resonance imagingvoxel-based morphometrybrain atrophyspontaneously hypertensive ratNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution DOAJ
collection DOAJ
language EN
topic hypertension
aging
magnetic resonance imaging
voxel-based morphometry
brain atrophy
spontaneously hypertensive rat
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
spellingShingle hypertension
aging
magnetic resonance imaging
voxel-based morphometry
brain atrophy
spontaneously hypertensive rat
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Yingying Yang
Yingying Yang
Quan Zhang
Jialiang Ren
Qingfeng Zhu
Lixin Wang
Yongzhi Zhang
Zuojun Geng
Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study
description The influence of hypertension and aging alone on brain structure has been described extensively. Our understanding of the interaction of hypertension with aging to brain morphology is still limited. We aimed to detect the synergistic effects of hypertension and aging on brain morphology and to describe the evolution patterns of cerebral atrophy from spatial and temporal perspectives. In 8 spontaneously hypertensive rats (SHRs) and 5 Wistar-Kyoto rats, high-resolution magnetic resonance imaging scans were longitudinally acquired at 10, 24, 52, and 80 weeks. We analyzed the tissue volumes of gray matter, white matter, cerebral spinal fluid, and total intracranial volume (TIV), and then evaluated gray matter volume in detail using voxel-based morphometry (VBM) and region of interest-based methods. There were interactive effects on hypertension and aging in tissue volumes of gray matter, white matter, and TIV, of which gray matter atrophy was most pronounced, especially in elderly SHRs. We identified the vulnerable gray matter volume with combined effects of hypertension and aging in the septal region, bilateral caudate putamen, hippocampus, primary somatosensory cortex, cerebellum, periaqueductal gray, right accumbens nucleus, and thalamus. We automatically extracted the septal region, anterior cingulate cortex, primary somatosensory cortex, caudate putamen, hippocampus, and accumbens nucleus and revealed an inverted-U trajectory of volume change in SHRs, with volume increase at the early phase and decline at the late phase. Hypertension interacts with aging to affect brain volume changes such as severe atrophy in elderly SHRs.
format article
author Yingying Yang
Yingying Yang
Quan Zhang
Jialiang Ren
Qingfeng Zhu
Lixin Wang
Yongzhi Zhang
Zuojun Geng
author_facet Yingying Yang
Yingying Yang
Quan Zhang
Jialiang Ren
Qingfeng Zhu
Lixin Wang
Yongzhi Zhang
Zuojun Geng
author_sort Yingying Yang
title Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study
title_short Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study
title_full Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study
title_fullStr Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study
title_full_unstemmed Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study
title_sort evolution of brain morphology in spontaneously hypertensive and wistar-kyoto rats from early adulthood to aging: a longitudinal magnetic resonance imaging study
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/4011ce878578437d8f6d16a4905d0ccc
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