Metabolic disorders associated with early menopause in the female population of Eastern Siberia: results of a cross-sectional study

Background. Menopause is an independent predictor of the development of metabolic syndrome, in the pathogenesis of which insulin resistance plays a leading role. Early menopause occurs in 5 % of women and, according to several studies, is associated with an increased risk of cardiovascular disease (...

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Autores principales:	Ia. G. Nadeliaeva, M. D. Salimova, I. N. Danusevich, L. M. Lasareva, L. F. Sholokhov, L. V. Belenkaya, N. I. Vilson, A. V. Atalyan, L. V. Natyaganova, L. V. Suturina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	early menopause metabolic syndrome cardiovascular diseases Science Q
Acceso en línea:	https://doaj.org/article/401fb5ffad4542a98e8e795abf73a633
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spelling	oai:doaj.org-article:401fb5ffad4542a98e8e795abf73a6332021-11-23T06:14:46ZMetabolic disorders associated with early menopause in the female population of Eastern Siberia: results of a cross-sectional study2541-94202587-959610.29413/ABS.2021-6.5.2https://doaj.org/article/401fb5ffad4542a98e8e795abf73a6332021-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/3025https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Menopause is an independent predictor of the development of metabolic syndrome, in the pathogenesis of which insulin resistance plays a leading role. Early menopause occurs in 5 % of women and, according to several studies, is associated with an increased risk of cardiovascular disease (CVD), which is one of the leading causes of death. The features of the course of metabolic syndrome in women with early menopause have not been sufficiently studied.The aim: to establish the prevalence of early menopause and its metabolic complications in the female population of Eastern Siberia.Materials and methods. The study population included 2695 women aged 18 to 80 years, who underwent the annual medical examination. The period of the study was March 2016 – December 2019. Among the surveyed women of 41–45 years old, a group of patients with early menopause (n = 18) and controls (n = 25) were identified. The diagnosis was made according to the STRAW criteria. The study used clinical, instrumental and laboratory research methods, including the assessment of hormonal and biochemical parameters, as well as the assessment of questionnaire data and statistical analysis.Results. The examined women with early menopause have an increase in BMI, waist volume, arterial hypertension, and an increase in the level of triglycerides and gonadotropic hormones. These changes potentially underlie the relationship between menopause and cardio-metabolic disease.Conclusion. These findings indicate the need to monitor the hormonal and metabolic parameters in this category of women to ensure timely prevention and correction of long-term complications associated with early menopause.Ia. G. NadeliaevaM. D. SalimovaI. N. DanusevichL. M. LasarevaL. F. SholokhovL. V. BelenkayaN. I. VilsonA. V. AtalyanL. V. NatyaganovaL. V. SuturinaScientific Сentre for Family Health and Human Reproduction Problemsarticleearly menopausemetabolic syndromecardiovascular diseasesScienceQRUActa Biomedica Scientifica, Vol 6, Iss 5, Pp 12-18 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	early menopause metabolic syndrome cardiovascular diseases Science Q
spellingShingle	early menopause metabolic syndrome cardiovascular diseases Science Q Ia. G. Nadeliaeva M. D. Salimova I. N. Danusevich L. M. Lasareva L. F. Sholokhov L. V. Belenkaya N. I. Vilson A. V. Atalyan L. V. Natyaganova L. V. Suturina Metabolic disorders associated with early menopause in the female population of Eastern Siberia: results of a cross-sectional study
description	Background. Menopause is an independent predictor of the development of metabolic syndrome, in the pathogenesis of which insulin resistance plays a leading role. Early menopause occurs in 5 % of women and, according to several studies, is associated with an increased risk of cardiovascular disease (CVD), which is one of the leading causes of death. The features of the course of metabolic syndrome in women with early menopause have not been sufficiently studied.The aim: to establish the prevalence of early menopause and its metabolic complications in the female population of Eastern Siberia.Materials and methods. The study population included 2695 women aged 18 to 80 years, who underwent the annual medical examination. The period of the study was March 2016 – December 2019. Among the surveyed women of 41–45 years old, a group of patients with early menopause (n = 18) and controls (n = 25) were identified. The diagnosis was made according to the STRAW criteria. The study used clinical, instrumental and laboratory research methods, including the assessment of hormonal and biochemical parameters, as well as the assessment of questionnaire data and statistical analysis.Results. The examined women with early menopause have an increase in BMI, waist volume, arterial hypertension, and an increase in the level of triglycerides and gonadotropic hormones. These changes potentially underlie the relationship between menopause and cardio-metabolic disease.Conclusion. These findings indicate the need to monitor the hormonal and metabolic parameters in this category of women to ensure timely prevention and correction of long-term complications associated with early menopause.
format	article
author	Ia. G. Nadeliaeva M. D. Salimova I. N. Danusevich L. M. Lasareva L. F. Sholokhov L. V. Belenkaya N. I. Vilson A. V. Atalyan L. V. Natyaganova L. V. Suturina
author_facet	Ia. G. Nadeliaeva M. D. Salimova I. N. Danusevich L. M. Lasareva L. F. Sholokhov L. V. Belenkaya N. I. Vilson A. V. Atalyan L. V. Natyaganova L. V. Suturina
author_sort	Ia. G. Nadeliaeva
title	Metabolic disorders associated with early menopause in the female population of Eastern Siberia: results of a cross-sectional study
title_short	Metabolic disorders associated with early menopause in the female population of Eastern Siberia: results of a cross-sectional study
title_full	Metabolic disorders associated with early menopause in the female population of Eastern Siberia: results of a cross-sectional study
title_fullStr	Metabolic disorders associated with early menopause in the female population of Eastern Siberia: results of a cross-sectional study
title_full_unstemmed	Metabolic disorders associated with early menopause in the female population of Eastern Siberia: results of a cross-sectional study
title_sort	metabolic disorders associated with early menopause in the female population of eastern siberia: results of a cross-sectional study
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/401fb5ffad4542a98e8e795abf73a633
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Metabolic disorders associated with early menopause in the female population of Eastern Siberia: results of a cross-sectional study

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