Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome

Abstract Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studies have used the sequencing of the bacterial 16S marker gene but have not reported the metabolic function of the gut microbiome, which may mediate biological effects on the host. H...

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Autores principales:	Petri Vänni, Mysore V. Tejesvi, Sofia Ainonen, Marjo Renko, Katja Korpela, Jarmo Salo, Niko Paalanne, Terhi Tapiainen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40221b33d55d47e69d856b3718448e23
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spelling	oai:doaj.org-article:40221b33d55d47e69d856b3718448e232021-12-02T17:51:21ZDelivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome10.1038/s41598-021-97007-x2045-2322https://doaj.org/article/40221b33d55d47e69d856b3718448e232021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97007-xhttps://doaj.org/toc/2045-2322Abstract Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studies have used the sequencing of the bacterial 16S marker gene but have not reported the metabolic function of the gut microbiome, which may mediate biological effects on the host. Here, we used the PICRUSt2 bioinformatics tool to predict the functional profiles of the gut microbiome based on 16S sequencing in two child cohorts. Both Caesarean section and perinatal antibiotics markedly influenced the functional profiles of the gut microbiome at the age of 1 year. In machine learning analysis, bacterial fatty acid, phospholipid, and biotin biosynthesis were the most important pathways that differed according to delivery mode. Proteinogenic amino acid biosynthesis, carbohydrate degradation, pyrimidine deoxyribonucleotide and biotin biosynthesis were the most important pathways differing according to antibiotic exposure. Our study shows that both Caesarean section and perinatal antibiotics markedly influence the predicted metabolic profiles of the gut microbiome at the age of 1 year.Petri VänniMysore V. TejesviSofia AinonenMarjo RenkoKatja KorpelaJarmo SaloNiko PaalanneTerhi TapiainenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Petri Vänni Mysore V. Tejesvi Sofia Ainonen Marjo Renko Katja Korpela Jarmo Salo Niko Paalanne Terhi Tapiainen Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome
description	Abstract Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studies have used the sequencing of the bacterial 16S marker gene but have not reported the metabolic function of the gut microbiome, which may mediate biological effects on the host. Here, we used the PICRUSt2 bioinformatics tool to predict the functional profiles of the gut microbiome based on 16S sequencing in two child cohorts. Both Caesarean section and perinatal antibiotics markedly influenced the functional profiles of the gut microbiome at the age of 1 year. In machine learning analysis, bacterial fatty acid, phospholipid, and biotin biosynthesis were the most important pathways that differed according to delivery mode. Proteinogenic amino acid biosynthesis, carbohydrate degradation, pyrimidine deoxyribonucleotide and biotin biosynthesis were the most important pathways differing according to antibiotic exposure. Our study shows that both Caesarean section and perinatal antibiotics markedly influence the predicted metabolic profiles of the gut microbiome at the age of 1 year.
format	article
author	Petri Vänni Mysore V. Tejesvi Sofia Ainonen Marjo Renko Katja Korpela Jarmo Salo Niko Paalanne Terhi Tapiainen
author_facet	Petri Vänni Mysore V. Tejesvi Sofia Ainonen Marjo Renko Katja Korpela Jarmo Salo Niko Paalanne Terhi Tapiainen
author_sort	Petri Vänni
title	Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome
title_short	Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome
title_full	Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome
title_fullStr	Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome
title_full_unstemmed	Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome
title_sort	delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40221b33d55d47e69d856b3718448e23
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Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome

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