A PHARMACEUTICAL FORMULATION DEVELOPMENT USING A EXPERIMENTAL MIXTURE DESIGN

The principal aim of this paper is to apply the experimental design of mixtures to formulate a solid dosage form (ibuprofen) through the study of the excipients and their proportion in the formulation. Besides it shows to the research and development teams in the pharmaceutical national companies h...

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Autores principales:	Juan F. PINILLOS M., Carlos M. LOPERA G.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	experimental design of mixtures research and development surface of response. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/402253b752b44c088cd18057ed1d8884
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spelling	oai:doaj.org-article:402253b752b44c088cd18057ed1d88842021-11-19T04:14:53ZA PHARMACEUTICAL FORMULATION DEVELOPMENT USING A EXPERIMENTAL MIXTURE DESIGN0121-40042145-2660https://doaj.org/article/402253b752b44c088cd18057ed1d88842009-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/2804https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 The principal aim of this paper is to apply the experimental design of mixtures to formulate a solid dosage form (ibuprofen) through the study of the excipients and their proportion in the formulation. Besides it shows to the research and development teams in the pharmaceutical national companies how they can use statistical tools like the experimental design of mixtures to obtain a product with the required characteristics. The optimization of this one reduces not only the costs of investigation but also the costs of production. The experimental design of mixtures allows to typify the performance of the ibuprofeno formulation from the pharmatechnic point of view, as well as the angle of rest, hardness of the nucleus and friability. Besides Carr’s’s index, characterizing a surface of response that allows an efficient utilization of this methodology for the resolution of the problem of formulation. The angle of rest shows that it is necessary to improve the fluency of the formulation to guarantee a correct filling of the counterfoils in the rattling process on an industrial scale. The parameters of hardness and friability show that the formulations are correct and that it is possible to continue with a process to optimize the formulation. Juan F. PINILLOS M.Carlos M. LOPERA G.Universidad de Antioquiaarticleexperimental design of mixturesresearch and developmentsurface of response.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 16, Iss 3 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	experimental design of mixtures research and development surface of response. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	experimental design of mixtures research and development surface of response. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Juan F. PINILLOS M. Carlos M. LOPERA G. A PHARMACEUTICAL FORMULATION DEVELOPMENT USING A EXPERIMENTAL MIXTURE DESIGN
description	The principal aim of this paper is to apply the experimental design of mixtures to formulate a solid dosage form (ibuprofen) through the study of the excipients and their proportion in the formulation. Besides it shows to the research and development teams in the pharmaceutical national companies how they can use statistical tools like the experimental design of mixtures to obtain a product with the required characteristics. The optimization of this one reduces not only the costs of investigation but also the costs of production. The experimental design of mixtures allows to typify the performance of the ibuprofeno formulation from the pharmatechnic point of view, as well as the angle of rest, hardness of the nucleus and friability. Besides Carr’s’s index, characterizing a surface of response that allows an efficient utilization of this methodology for the resolution of the problem of formulation. The angle of rest shows that it is necessary to improve the fluency of the formulation to guarantee a correct filling of the counterfoils in the rattling process on an industrial scale. The parameters of hardness and friability show that the formulations are correct and that it is possible to continue with a process to optimize the formulation.
format	article
author	Juan F. PINILLOS M. Carlos M. LOPERA G.
author_facet	Juan F. PINILLOS M. Carlos M. LOPERA G.
author_sort	Juan F. PINILLOS M.
title	A PHARMACEUTICAL FORMULATION DEVELOPMENT USING A EXPERIMENTAL MIXTURE DESIGN
title_short	A PHARMACEUTICAL FORMULATION DEVELOPMENT USING A EXPERIMENTAL MIXTURE DESIGN
title_full	A PHARMACEUTICAL FORMULATION DEVELOPMENT USING A EXPERIMENTAL MIXTURE DESIGN
title_fullStr	A PHARMACEUTICAL FORMULATION DEVELOPMENT USING A EXPERIMENTAL MIXTURE DESIGN
title_full_unstemmed	A PHARMACEUTICAL FORMULATION DEVELOPMENT USING A EXPERIMENTAL MIXTURE DESIGN
title_sort	pharmaceutical formulation development using a experimental mixture design
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/402253b752b44c088cd18057ed1d8884
work_keys_str_mv	AT juanfpinillosm apharmaceuticalformulationdevelopmentusingaexperimentalmixturedesign AT carlosmloperag apharmaceuticalformulationdevelopmentusingaexperimentalmixturedesign AT juanfpinillosm pharmaceuticalformulationdevelopmentusingaexperimentalmixturedesign AT carlosmloperag pharmaceuticalformulationdevelopmentusingaexperimentalmixturedesign
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A PHARMACEUTICAL FORMULATION DEVELOPMENT USING A EXPERIMENTAL MIXTURE DESIGN

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