Retrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate Alzheimer's disease

Retrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate Alzheimer's disease

Steven Douglas Maynard,1,2 Jeff Gelblum31Union Associated Physicians Clinic, 2Indiana University School of Medicine, Terre Haute, IN, 3Mt Sinai Medical Center of Miami, Aventura Hospital, Aventura, FL, USAAbstract: Under normal conditions, the adult human brain is fueled primarily by glucose. A prom...

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Autores principales: Maynard SD, Gelblum J
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/402888dbf20b4af4bd076c348d2c6989
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spelling oai:doaj.org-article:402888dbf20b4af4bd076c348d2c69892021-12-02T01:55:19ZRetrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate Alzheimer's disease1176-63281178-2021https://doaj.org/article/402888dbf20b4af4bd076c348d2c69892013-10-01T00:00:00Zhttp://www.dovepress.com/retrospective-case-studies-of-the-efficacy-of-caprylic-triglyceride-in-a14766https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Steven Douglas Maynard,1,2 Jeff Gelblum31Union Associated Physicians Clinic, 2Indiana University School of Medicine, Terre Haute, IN, 3Mt Sinai Medical Center of Miami, Aventura Hospital, Aventura, FL, USAAbstract: Under normal conditions, the adult human brain is fueled primarily by glucose. A prominent feature of Alzheimer's disease (AD) is region-specific decreases in cerebral glucose metabolism. Ketone bodies are a group of compounds produced from fat stores during periods of low glucose availability that can provide an alternative to glucose for brain metabolism. Consumption of sufficient quantities of caprylic triglyceride (CT) increases plasma concentrations of ketone bodies and may be beneficial in conditions of compromised glucose metabolism, such as AD. The present study describes the use of CT in mild-to-moderate AD in routine clinical practice. Case records from eight patients with extensive monitoring of cognitive function using the Mini-Mental State Examination (MMSE) and who had received CT for ≥6 months were reviewed. All were outpatients aged ≥50 years, cared for in standard practice, had a diagnosis of probable AD of mild-to-moderate severity (MMSE 14–24), and had received CT for at least 6 months in addition to other approved pharmacotherapy for AD. Response to CT administration as measured by MMSE scores varied by patient. However, the rate of decline in MMSE scores appeared slower than previously published reports for patients treated with pharmacotherapy alone. Profiling of individual patients may provide insight regarding those most likely to benefit from addition of CT to currently approved AD pharmacotherapy.Keywords: ketosis, cognition, Alzheimer's disease, metabolism, glucoseMaynard SDGelblum JDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 1629-1635 (2013)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Maynard SD
Gelblum J
Retrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate Alzheimer's disease
description Steven Douglas Maynard,1,2 Jeff Gelblum31Union Associated Physicians Clinic, 2Indiana University School of Medicine, Terre Haute, IN, 3Mt Sinai Medical Center of Miami, Aventura Hospital, Aventura, FL, USAAbstract: Under normal conditions, the adult human brain is fueled primarily by glucose. A prominent feature of Alzheimer's disease (AD) is region-specific decreases in cerebral glucose metabolism. Ketone bodies are a group of compounds produced from fat stores during periods of low glucose availability that can provide an alternative to glucose for brain metabolism. Consumption of sufficient quantities of caprylic triglyceride (CT) increases plasma concentrations of ketone bodies and may be beneficial in conditions of compromised glucose metabolism, such as AD. The present study describes the use of CT in mild-to-moderate AD in routine clinical practice. Case records from eight patients with extensive monitoring of cognitive function using the Mini-Mental State Examination (MMSE) and who had received CT for ≥6 months were reviewed. All were outpatients aged ≥50 years, cared for in standard practice, had a diagnosis of probable AD of mild-to-moderate severity (MMSE 14–24), and had received CT for at least 6 months in addition to other approved pharmacotherapy for AD. Response to CT administration as measured by MMSE scores varied by patient. However, the rate of decline in MMSE scores appeared slower than previously published reports for patients treated with pharmacotherapy alone. Profiling of individual patients may provide insight regarding those most likely to benefit from addition of CT to currently approved AD pharmacotherapy.Keywords: ketosis, cognition, Alzheimer's disease, metabolism, glucose
format article
author Maynard SD
Gelblum J
author_facet Maynard SD
Gelblum J
author_sort Maynard SD
title Retrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate Alzheimer's disease
title_short Retrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate Alzheimer's disease
title_full Retrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate Alzheimer's disease
title_fullStr Retrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate Alzheimer's disease
title_full_unstemmed Retrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate Alzheimer's disease
title_sort retrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate alzheimer's disease
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/402888dbf20b4af4bd076c348d2c6989
work_keys_str_mv AT maynardsd retrospectivecasestudiesoftheefficacyofcaprylictriglycerideinmildtomoderatealzheimer39sdisease
AT gelblumj retrospectivecasestudiesoftheefficacyofcaprylictriglycerideinmildtomoderatealzheimer39sdisease
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