APRESS: apical regulatory super system, serotonin, and dopamine interaction

Marty Hinz1, Alvin Stein2, Thomas Uncini31Clinical Research, NeuroResearch Clinics, Inc, Cape Coral, FL, USA; 2Stein Orthopedic Associates, Plantation, FL, USA; 3DBS Labs, Duluth, MN, USABackground: The monoamines serotonin and dopamine are known to exist in two separate states: the endogenous state...

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Autores principales:	Hinz M, Stein A, Uncini T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/402af5f391d345199f49691fd31cec1d
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spelling	oai:doaj.org-article:402af5f391d345199f49691fd31cec1d2021-12-02T03:48:19ZAPRESS: apical regulatory super system, serotonin, and dopamine interaction1176-63281178-2021https://doaj.org/article/402af5f391d345199f49691fd31cec1d2011-08-01T00:00:00Zhttp://www.dovepress.com/apress-apical-regulatory-super-system-serotonin-and-dopamine-interacti-a8030https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Marty Hinz1, Alvin Stein2, Thomas Uncini31Clinical Research, NeuroResearch Clinics, Inc, Cape Coral, FL, USA; 2Stein Orthopedic Associates, Plantation, FL, USA; 3DBS Labs, Duluth, MN, USABackground: The monoamines serotonin and dopamine are known to exist in two separate states: the endogenous state and the competitive inhibition state. The presence of the competitive inhibition state has been known to science for many years, but from a functional standpoint it has been noted in the literature as being &quot;meaningless.&quot;Methods: A large database of monoamine transporter response to amino acid precursor administration variations with clinical outcomes was accumulated. In the process, a new organic cation transporter (OCT) model has been published, and OCT functional status determination along with amino acid precursor manipulation methods have been invented and refined.Results: Methodology was developed whereby manipulation of the OCT, in the competitive inhibition state, is carried out in a predictable manner. This, in turn, has disproved the long-held assertion that the monoamine competitive inhibition state is functionally meaningless.Conclusion: The most significant aspect of this paper is the documentation of newly recognized relationships between serotonin and dopamine. When transport of serotonin and dopamine are both in the competitive inhibition state, manipulation of the concentrations of one will lead to predictable changes in concentrations of the other. From a functional standpoint, processes regulated and controlled by changes to only serotonin can now be controlled by changes to dopamine, and vice versa, in a predictable manner.Keywords: catecholamine, monoamine, competitive inhibition stateHinz MStein AUncini TDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2011, Iss Issue 1, Pp 457-463 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hinz M Stein A Uncini T APRESS: apical regulatory super system, serotonin, and dopamine interaction
description	Marty Hinz1, Alvin Stein2, Thomas Uncini31Clinical Research, NeuroResearch Clinics, Inc, Cape Coral, FL, USA; 2Stein Orthopedic Associates, Plantation, FL, USA; 3DBS Labs, Duluth, MN, USABackground: The monoamines serotonin and dopamine are known to exist in two separate states: the endogenous state and the competitive inhibition state. The presence of the competitive inhibition state has been known to science for many years, but from a functional standpoint it has been noted in the literature as being &quot;meaningless.&quot;Methods: A large database of monoamine transporter response to amino acid precursor administration variations with clinical outcomes was accumulated. In the process, a new organic cation transporter (OCT) model has been published, and OCT functional status determination along with amino acid precursor manipulation methods have been invented and refined.Results: Methodology was developed whereby manipulation of the OCT, in the competitive inhibition state, is carried out in a predictable manner. This, in turn, has disproved the long-held assertion that the monoamine competitive inhibition state is functionally meaningless.Conclusion: The most significant aspect of this paper is the documentation of newly recognized relationships between serotonin and dopamine. When transport of serotonin and dopamine are both in the competitive inhibition state, manipulation of the concentrations of one will lead to predictable changes in concentrations of the other. From a functional standpoint, processes regulated and controlled by changes to only serotonin can now be controlled by changes to dopamine, and vice versa, in a predictable manner.Keywords: catecholamine, monoamine, competitive inhibition state
format	article
author	Hinz M Stein A Uncini T
author_facet	Hinz M Stein A Uncini T
author_sort	Hinz M
title	APRESS: apical regulatory super system, serotonin, and dopamine interaction
title_short	APRESS: apical regulatory super system, serotonin, and dopamine interaction
title_full	APRESS: apical regulatory super system, serotonin, and dopamine interaction
title_fullStr	APRESS: apical regulatory super system, serotonin, and dopamine interaction
title_full_unstemmed	APRESS: apical regulatory super system, serotonin, and dopamine interaction
title_sort	apress: apical regulatory super system, serotonin, and dopamine interaction
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/402af5f391d345199f49691fd31cec1d
work_keys_str_mv	AT hinzm apressapicalregulatorysupersystemserotoninanddopamineinteraction AT steina apressapicalregulatorysupersystemserotoninanddopamineinteraction AT uncinit apressapicalregulatorysupersystemserotoninanddopamineinteraction
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APRESS: apical regulatory super system, serotonin, and dopamine interaction

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