FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH RECURRENT HERPETIC INFECTION

Abstract. Cytokines play an important role in resistance to herpesvirus infections. Therefore, studies of cytokine profile are necessary in recurrent herpetic infection. However, functional studies of cytokine network upon remission of the disease yielded controversial results. In this paper, we pro...

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Autores principales:	I. A. Novikovа, O. A. Romanivа
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	herpes infection remission cytokine production Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/402ba171664044f295d33b6a09a43ed4
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spelling	oai:doaj.org-article:402ba171664044f295d33b6a09a43ed42021-11-18T08:03:43ZFEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH RECURRENT HERPETIC INFECTION1563-06252313-741X10.15789/1563-0625-2013-6-571-576https://doaj.org/article/402ba171664044f295d33b6a09a43ed42014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/666https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Cytokines play an important role in resistance to herpesvirus infections. Therefore, studies of cytokine profile are necessary in recurrent herpetic infection. However, functional studies of cytokine network upon remission of the disease yielded controversial results. In this paper, we provide some results concerning comprehensive evaluation of ex vivo cytokine production by whole blood leukocytes drawn from 15 patients observed during clinical remission of recurrent Herpes Simplex virus infection. We have found a decrease of IL-1β, IL-8 and IL-10 production, as well as imbalance of cytokine profile, with predominance of IFNγ and IL-8 synthesis over IL-10 production, along with increased IL-4 and IL-13 levels to IL-1β contents. Differently directed correlations between the content of activated lymphocytes (CD3+HLA-DR+ and CD3+CD4+CD25+), natural killers (СD3-СD16/56+), NKT-cells and cytokine production levels were found in the groups of patients and healthy individuals. These differences may be due to shifts in major cytokineproducing populations in herpesvirus infections.I. A. NovikovаO. A. RomanivаSPb RAACIarticleherpes infectionremissioncytokine productionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 6, Pp 571-576 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	herpes infection remission cytokine production Immunologic diseases. Allergy RC581-607
spellingShingle	herpes infection remission cytokine production Immunologic diseases. Allergy RC581-607 I. A. Novikovа O. A. Romanivа FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH RECURRENT HERPETIC INFECTION
description	Abstract. Cytokines play an important role in resistance to herpesvirus infections. Therefore, studies of cytokine profile are necessary in recurrent herpetic infection. However, functional studies of cytokine network upon remission of the disease yielded controversial results. In this paper, we provide some results concerning comprehensive evaluation of ex vivo cytokine production by whole blood leukocytes drawn from 15 patients observed during clinical remission of recurrent Herpes Simplex virus infection. We have found a decrease of IL-1β, IL-8 and IL-10 production, as well as imbalance of cytokine profile, with predominance of IFNγ and IL-8 synthesis over IL-10 production, along with increased IL-4 and IL-13 levels to IL-1β contents. Differently directed correlations between the content of activated lymphocytes (CD3+HLA-DR+ and CD3+CD4+CD25+), natural killers (СD3-СD16/56+), NKT-cells and cytokine production levels were found in the groups of patients and healthy individuals. These differences may be due to shifts in major cytokineproducing populations in herpesvirus infections.
format	article
author	I. A. Novikovа O. A. Romanivа
author_facet	I. A. Novikovа O. A. Romanivа
author_sort	I. A. Novikovа
title	FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH RECURRENT HERPETIC INFECTION
title_short	FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH RECURRENT HERPETIC INFECTION
title_full	FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH RECURRENT HERPETIC INFECTION
title_fullStr	FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH RECURRENT HERPETIC INFECTION
title_full_unstemmed	FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH RECURRENT HERPETIC INFECTION
title_sort	features of cytokine production in patients with recurrent herpetic infection
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/402ba171664044f295d33b6a09a43ed4
work_keys_str_mv	AT ianovikova featuresofcytokineproductioninpatientswithrecurrentherpeticinfection AT oaromaniva featuresofcytokineproductioninpatientswithrecurrentherpeticinfection
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FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH RECURRENT HERPETIC INFECTION

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