Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer

Over the last several years, many advances have been made in understanding the role of bacteria in the pathogenesis of gastrointestinal cancers. Beginning with Helicobacter pylori being recognized as the first bacterial carcinogen and the causative agent of most gastric cancers, more recent studies...

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Autores principales:	Laure Campillo-Gimenez, David Rios-Covian, Jesus Rivera-Nieves, Hiroshi Kiyono, Hiutung Chu, Peter B. Ernst
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	microbiome IBD CRC T/B cell repertoire immune memory microbiome-editing Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/402cce078615446388cc41b23d1f8e2c
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spelling	oai:doaj.org-article:402cce078615446388cc41b23d1f8e2c2021-11-12T05:42:58ZMicrobial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer2235-298810.3389/fcimb.2021.752304https://doaj.org/article/402cce078615446388cc41b23d1f8e2c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.752304/fullhttps://doaj.org/toc/2235-2988Over the last several years, many advances have been made in understanding the role of bacteria in the pathogenesis of gastrointestinal cancers. Beginning with Helicobacter pylori being recognized as the first bacterial carcinogen and the causative agent of most gastric cancers, more recent studies have examined the role of enteric microbes in colorectal cancer. In the digestive tract, these communities are numerous and have a complex interrelationship with local immune/inflammatory responses that impact the health of the host. As modifying the microbiome in the stomach has decreased the risk of gastric cancer, modifying the distal microbiome may decrease the risk of colorectal cancers. To date, very few studies have considered the notion that mucosal lymphocyte-dependent immune memory may confound attempts to change the microbial components in these communities. The goal of this review is to consider some of the factors impacting host-microbial interactions that affect colorectal cancer and raise questions about how immune memory responses to the local microbial consortium affect any attempt to modify the composition of the intestinal microbiome.Laure Campillo-GimenezDavid Rios-CovianJesus Rivera-NievesJesus Rivera-NievesHiroshi KiyonoHiroshi KiyonoHiroshi KiyonoHiutung ChuHiutung ChuPeter B. ErnstPeter B. ErnstPeter B. ErnstPeter B. ErnstFrontiers Media S.A.articlemicrobiomeIBDCRCT/B cell repertoireimmune memorymicrobiome-editingMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microbiome IBD CRC T/B cell repertoire immune memory microbiome-editing Microbiology QR1-502
spellingShingle	microbiome IBD CRC T/B cell repertoire immune memory microbiome-editing Microbiology QR1-502 Laure Campillo-Gimenez David Rios-Covian Jesus Rivera-Nieves Jesus Rivera-Nieves Hiroshi Kiyono Hiroshi Kiyono Hiroshi Kiyono Hiutung Chu Hiutung Chu Peter B. Ernst Peter B. Ernst Peter B. Ernst Peter B. Ernst Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer
description	Over the last several years, many advances have been made in understanding the role of bacteria in the pathogenesis of gastrointestinal cancers. Beginning with Helicobacter pylori being recognized as the first bacterial carcinogen and the causative agent of most gastric cancers, more recent studies have examined the role of enteric microbes in colorectal cancer. In the digestive tract, these communities are numerous and have a complex interrelationship with local immune/inflammatory responses that impact the health of the host. As modifying the microbiome in the stomach has decreased the risk of gastric cancer, modifying the distal microbiome may decrease the risk of colorectal cancers. To date, very few studies have considered the notion that mucosal lymphocyte-dependent immune memory may confound attempts to change the microbial components in these communities. The goal of this review is to consider some of the factors impacting host-microbial interactions that affect colorectal cancer and raise questions about how immune memory responses to the local microbial consortium affect any attempt to modify the composition of the intestinal microbiome.
format	article
author	Laure Campillo-Gimenez David Rios-Covian Jesus Rivera-Nieves Jesus Rivera-Nieves Hiroshi Kiyono Hiroshi Kiyono Hiroshi Kiyono Hiutung Chu Hiutung Chu Peter B. Ernst Peter B. Ernst Peter B. Ernst Peter B. Ernst
author_facet	Laure Campillo-Gimenez David Rios-Covian Jesus Rivera-Nieves Jesus Rivera-Nieves Hiroshi Kiyono Hiroshi Kiyono Hiroshi Kiyono Hiutung Chu Hiutung Chu Peter B. Ernst Peter B. Ernst Peter B. Ernst Peter B. Ernst
author_sort	Laure Campillo-Gimenez
title	Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer
title_short	Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer
title_full	Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer
title_fullStr	Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer
title_full_unstemmed	Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer
title_sort	microbial-driven immunological memory and its potential role in microbiome editing for the prevention of colorectal cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/402cce078615446388cc41b23d1f8e2c
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Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer

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