Associations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural China

Abstract We evaluated how metabolic disorders affected antihypertension therapy. 2,912 rural Chinese patients with hypertension who provided blood samples, demographic and clinical data at baseline and after 1 year of antihypertension therapy were evaluated. At baseline, 1,515 patients (52.0%) were...

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Autores principales:	Jing Xiao, Tianqi Hua, Huan Shen, Min Zhang, Xiao-Jian Wang, Yue-Xia Gao, Qinyun Lu, Chuanli Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/402f9885428345e790de1a4ae1007c2a
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spelling	oai:doaj.org-article:402f9885428345e790de1a4ae1007c2a2021-12-02T12:31:59ZAssociations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural China10.1038/s41598-017-00789-22045-2322https://doaj.org/article/402f9885428345e790de1a4ae1007c2a2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00789-2https://doaj.org/toc/2045-2322Abstract We evaluated how metabolic disorders affected antihypertension therapy. 2,912 rural Chinese patients with hypertension who provided blood samples, demographic and clinical data at baseline and after 1 year of antihypertension therapy were evaluated. At baseline, 1,515 patients (52.0%) were already receiving drug therapy and 11.4% of them had controlled blood pressure (BP). After 1 year, all 2,912 patients were receiving antihypertension therapy that was administered by community physicians, and 59.42% of them had controlled BP. Central obesity and abnormal triglyceride, high-density lipoprotein cholesterol, and glucose were associated with 15–70% higher risks of uncontrolled hypertension. Metabolic syndrome using the JIS criteria was associated with poor BP control (odds ratio: 1.71 and 1.54 for the baseline and follow-up datasets, respectively). The risk of uncontrolled hypertension increased with the number of metabolic disorders (p for trend <0.01). The presence of ≥3 metabolic disorder factors was associated with higher risks of poor BP control. The associations of metabolic factors and uncontrolled hypertension were stronger for the standard and modified ATP III criteria, compared to the IDF and JIS criteria. Metabolic factors were associated with less effective antihypertension therapy, and all definitions of metabolic syndrome helped identify patients with elevated risks of uncontrolled hypertension.Jing XiaoTianqi HuaHuan ShenMin ZhangXiao-Jian WangYue-Xia GaoQinyun LuChuanli WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Xiao Tianqi Hua Huan Shen Min Zhang Xiao-Jian Wang Yue-Xia Gao Qinyun Lu Chuanli Wu Associations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural China
description	Abstract We evaluated how metabolic disorders affected antihypertension therapy. 2,912 rural Chinese patients with hypertension who provided blood samples, demographic and clinical data at baseline and after 1 year of antihypertension therapy were evaluated. At baseline, 1,515 patients (52.0%) were already receiving drug therapy and 11.4% of them had controlled blood pressure (BP). After 1 year, all 2,912 patients were receiving antihypertension therapy that was administered by community physicians, and 59.42% of them had controlled BP. Central obesity and abnormal triglyceride, high-density lipoprotein cholesterol, and glucose were associated with 15–70% higher risks of uncontrolled hypertension. Metabolic syndrome using the JIS criteria was associated with poor BP control (odds ratio: 1.71 and 1.54 for the baseline and follow-up datasets, respectively). The risk of uncontrolled hypertension increased with the number of metabolic disorders (p for trend <0.01). The presence of ≥3 metabolic disorder factors was associated with higher risks of poor BP control. The associations of metabolic factors and uncontrolled hypertension were stronger for the standard and modified ATP III criteria, compared to the IDF and JIS criteria. Metabolic factors were associated with less effective antihypertension therapy, and all definitions of metabolic syndrome helped identify patients with elevated risks of uncontrolled hypertension.
format	article
author	Jing Xiao Tianqi Hua Huan Shen Min Zhang Xiao-Jian Wang Yue-Xia Gao Qinyun Lu Chuanli Wu
author_facet	Jing Xiao Tianqi Hua Huan Shen Min Zhang Xiao-Jian Wang Yue-Xia Gao Qinyun Lu Chuanli Wu
author_sort	Jing Xiao
title	Associations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural China
title_short	Associations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural China
title_full	Associations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural China
title_fullStr	Associations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural China
title_full_unstemmed	Associations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural China
title_sort	associations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural china
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/402f9885428345e790de1a4ae1007c2a
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Associations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural China

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