The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat

Nicotine and alcohol use is highly prevalent among patients with serious mental illness, including those with schizophrenia (SCZ), and this co-occurrence can lead to a worsening of medical and psychiatric morbidity. While the mechanistic drivers of co-occurring SCZ, nicotine use and alcohol use are...

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Autores principales:	Emily D. K. Sullivan, Liam N. Locke, Diana J. Wallin, Jibran Y. Khokhar, Elise M. Bragg, Angela M. Henricks, Wilder T. Doucette
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	adolescent alcohol NVHL co-occurring disorders mental illness smoking nicotine behavioral sensitization Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/4036d534bb2a4eb9b84a90d2858fcf55
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spelling	oai:doaj.org-article:4036d534bb2a4eb9b84a90d2858fcf552021-11-11T10:25:18ZThe Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat1662-515310.3389/fnbeh.2021.760791https://doaj.org/article/4036d534bb2a4eb9b84a90d2858fcf552021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.760791/fullhttps://doaj.org/toc/1662-5153Nicotine and alcohol use is highly prevalent among patients with serious mental illness, including those with schizophrenia (SCZ), and this co-occurrence can lead to a worsening of medical and psychiatric morbidity. While the mechanistic drivers of co-occurring SCZ, nicotine use and alcohol use are unknown, emerging evidence suggests that the use of drugs during adolescence may increase the probability of developing psychiatric disorders. The current study used the neonatal ventral hippocampal lesion (NVHL) rat model of SCZ, which has previously been shown to have enhanced nicotine behavioral sensitization and, following adolescent alcohol, increased alcohol consumption. Given how commonly alcohol is used by adolescents that develop SCZ, we used the NVHL rat to determine how exposure to adolescent alcohol impacts the development of nicotine behavioral sensitization in adulthood. Male Sprague-Dawley rats underwent the NVHL surgery or a sham (control) surgery and subsequently, half of each group was allowed to drink alcohol during adolescence. Nicotine behavioral sensitization was assessed in adulthood with rats receiving subcutaneous injections of nicotine (0.5 mg/kg) each day for 3 weeks followed by a nicotine challenge session 2 weeks later. We demonstrate that all groups of rats became sensitized to nicotine and there were no NVHL-specific increases in nicotine behavioral sensitization. We also found that NVHL rats appeared to develop sensitization to the nicotine paired context and that adolescent alcohol exposure blocked this context sensitization. The current findings suggest that exposure to alcohol during adolescence can influence behaviors that manifest in the adult NVHL rat (i.e., context sensitization). Interestingly, nicotine behavioral sensitization levels were not altered in the NVHL groups regardless of adolescent alcohol exposure in contrast to prior reports.Emily D. K. SullivanEmily D. K. SullivanLiam N. LockeDiana J. WallinDiana J. WallinJibran Y. KhokharJibran Y. KhokharElise M. BraggAngela M. HenricksAngela M. HenricksWilder T. DoucetteWilder T. DoucetteFrontiers Media S.A.articleadolescent alcoholNVHLco-occurring disordersmental illnesssmokingnicotine behavioral sensitizationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adolescent alcohol NVHL co-occurring disorders mental illness smoking nicotine behavioral sensitization Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	adolescent alcohol NVHL co-occurring disorders mental illness smoking nicotine behavioral sensitization Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Emily D. K. Sullivan Emily D. K. Sullivan Liam N. Locke Diana J. Wallin Diana J. Wallin Jibran Y. Khokhar Jibran Y. Khokhar Elise M. Bragg Angela M. Henricks Angela M. Henricks Wilder T. Doucette Wilder T. Doucette The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat
description	Nicotine and alcohol use is highly prevalent among patients with serious mental illness, including those with schizophrenia (SCZ), and this co-occurrence can lead to a worsening of medical and psychiatric morbidity. While the mechanistic drivers of co-occurring SCZ, nicotine use and alcohol use are unknown, emerging evidence suggests that the use of drugs during adolescence may increase the probability of developing psychiatric disorders. The current study used the neonatal ventral hippocampal lesion (NVHL) rat model of SCZ, which has previously been shown to have enhanced nicotine behavioral sensitization and, following adolescent alcohol, increased alcohol consumption. Given how commonly alcohol is used by adolescents that develop SCZ, we used the NVHL rat to determine how exposure to adolescent alcohol impacts the development of nicotine behavioral sensitization in adulthood. Male Sprague-Dawley rats underwent the NVHL surgery or a sham (control) surgery and subsequently, half of each group was allowed to drink alcohol during adolescence. Nicotine behavioral sensitization was assessed in adulthood with rats receiving subcutaneous injections of nicotine (0.5 mg/kg) each day for 3 weeks followed by a nicotine challenge session 2 weeks later. We demonstrate that all groups of rats became sensitized to nicotine and there were no NVHL-specific increases in nicotine behavioral sensitization. We also found that NVHL rats appeared to develop sensitization to the nicotine paired context and that adolescent alcohol exposure blocked this context sensitization. The current findings suggest that exposure to alcohol during adolescence can influence behaviors that manifest in the adult NVHL rat (i.e., context sensitization). Interestingly, nicotine behavioral sensitization levels were not altered in the NVHL groups regardless of adolescent alcohol exposure in contrast to prior reports.
format	article
author	Emily D. K. Sullivan Emily D. K. Sullivan Liam N. Locke Diana J. Wallin Diana J. Wallin Jibran Y. Khokhar Jibran Y. Khokhar Elise M. Bragg Angela M. Henricks Angela M. Henricks Wilder T. Doucette Wilder T. Doucette
author_facet	Emily D. K. Sullivan Emily D. K. Sullivan Liam N. Locke Diana J. Wallin Diana J. Wallin Jibran Y. Khokhar Jibran Y. Khokhar Elise M. Bragg Angela M. Henricks Angela M. Henricks Wilder T. Doucette Wilder T. Doucette
author_sort	Emily D. K. Sullivan
title	The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat
title_short	The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat
title_full	The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat
title_fullStr	The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat
title_full_unstemmed	The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat
title_sort	impact of adolescent alcohol exposure on nicotine behavioral sensitization in the adult male neonatal ventral hippocampal lesion rat
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4036d534bb2a4eb9b84a90d2858fcf55
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The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat

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