Enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications

Phong Tran1, Thomas J Webster21Physics Department; 2Division of Engineering and Department of Orthopedics, Brown University, Providence, USAAbstract: Metallic bone implants possess numerous problems limiting their long-term efficacy, such as poor prolonged osseointegration, stress shielding, and cor...

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Autores principales:	Phong Tran, Thomas J Webster
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/40392741245e438481a8e1c33c3136d8
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spelling	oai:doaj.org-article:40392741245e438481a8e1c33c3136d82021-12-02T05:10:24ZEnhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications1176-91141178-2013https://doaj.org/article/40392741245e438481a8e1c33c3136d82008-10-01T00:00:00Zhttp://www.dovepress.com/enhanced-osteoblast-adhesion-on-nanostructured-selenium-compacts-for-a-a2440https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Phong Tran1, Thomas J Webster21Physics Department; 2Division of Engineering and Department of Orthopedics, Brown University, Providence, USAAbstract: Metallic bone implants possess numerous problems limiting their long-term efficacy, such as poor prolonged osseointegration, stress shielding, and corrosion under in vivo environments. Such problems are compounded for bone cancer patients since numerous patients receive orthopedic implants after cancerous bone resection. Unfortunately, current orthopedic materials were not originally developed to simultaneously increase healthy bone growth (as in traditional orthopedic implant applications) while inhibiting cancerous bone growth. The long-term objective of the present research is to investigate the use of nano-rough selenium to prevent bone cancer from re-occurring while promoting healthy bone growth for this select group of cancer patients. Selenium is a well known anti-cancer chemical. However, what is not known is how healthy bone cells interact with selenium. To determine this, selenium, spherical or semispherical shots, were pressed into cylindrical compacts and these compacts were then etched using 1N NaOH to obtain various surface structures ranging from the micron, submicron to nano scales. Changes in surface chemistry were also analyzed. Through these etching techniques, results of this study showed that biologically inspired surface roughness values were created on selenium compacts to match that of natural bone roughness. Moreover, results showed that healthy bone cell adhesion increased with greater nanometer selenium roughness (more closely matching that of titanium). In this manner, this study suggests that nano-rough selenium should be further tested for orthopedic applications involving bone cancer treatment.Keywords: selenium, nano-rough, osteoblast, cancer, chemopreventive Phong TranThomas J WebsterDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 3, Pp 391-396 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Phong Tran Thomas J Webster Enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications
description	Phong Tran1, Thomas J Webster21Physics Department; 2Division of Engineering and Department of Orthopedics, Brown University, Providence, USAAbstract: Metallic bone implants possess numerous problems limiting their long-term efficacy, such as poor prolonged osseointegration, stress shielding, and corrosion under in vivo environments. Such problems are compounded for bone cancer patients since numerous patients receive orthopedic implants after cancerous bone resection. Unfortunately, current orthopedic materials were not originally developed to simultaneously increase healthy bone growth (as in traditional orthopedic implant applications) while inhibiting cancerous bone growth. The long-term objective of the present research is to investigate the use of nano-rough selenium to prevent bone cancer from re-occurring while promoting healthy bone growth for this select group of cancer patients. Selenium is a well known anti-cancer chemical. However, what is not known is how healthy bone cells interact with selenium. To determine this, selenium, spherical or semispherical shots, were pressed into cylindrical compacts and these compacts were then etched using 1N NaOH to obtain various surface structures ranging from the micron, submicron to nano scales. Changes in surface chemistry were also analyzed. Through these etching techniques, results of this study showed that biologically inspired surface roughness values were created on selenium compacts to match that of natural bone roughness. Moreover, results showed that healthy bone cell adhesion increased with greater nanometer selenium roughness (more closely matching that of titanium). In this manner, this study suggests that nano-rough selenium should be further tested for orthopedic applications involving bone cancer treatment.Keywords: selenium, nano-rough, osteoblast, cancer, chemopreventive
format	article
author	Phong Tran Thomas J Webster
author_facet	Phong Tran Thomas J Webster
author_sort	Phong Tran
title	Enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications
title_short	Enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications
title_full	Enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications
title_fullStr	Enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications
title_full_unstemmed	Enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications
title_sort	enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/40392741245e438481a8e1c33c3136d8
work_keys_str_mv	AT phongtran enhancedosteoblastadhesiononnanostructuredseleniumcompactsforanticancerorthopedicapplications AT thomasjwebster enhancedosteoblastadhesiononnanostructuredseleniumcompactsforanticancerorthopedicapplications
_version_	1718400525866631168

Enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications

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