The characteristic AgcoreAushell nanoparticles as SERS substrates in detecting dopamine molecules at various pH ranges

Yanru Bu,1 Sang-Wha Lee2 1Department of Chemical Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, Australia; 2Department of Chemical and Biochemical Engineering, Gachon University, Seongnam-si, Gyeonggi-do, Republic of Korea Abstract: AgcoreAushell nanoparticles (NPs) are a...

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Autores principales:	Bu Y, Lee SW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/403a3b31c73e4a5baa7acc5ce35768c9
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spelling	oai:doaj.org-article:403a3b31c73e4a5baa7acc5ce35768c92021-12-02T00:04:48ZThe characteristic AgcoreAushell nanoparticles as SERS substrates in detecting dopamine molecules at various pH ranges1178-2013https://doaj.org/article/403a3b31c73e4a5baa7acc5ce35768c92015-08-01T00:00:00Zhttp://www.dovepress.com/the-characteristic-agcoreaushell-nanoparticles-as-sers-substrates-in-d-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yanru Bu,1 Sang-Wha Lee2 1Department of Chemical Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, Australia; 2Department of Chemical and Biochemical Engineering, Gachon University, Seongnam-si, Gyeonggi-do, Republic of Korea Abstract: AgcoreAushell nanoparticles (NPs) are a promising surface-enhanced Raman scattering (SERS) substrate, which can offer a high enhancement factor through the combined effect of the high SERS activity of the Ag core and the biocompatibility of the Au shell. In this study, AgcoreAushell NPs were examined as SERS substrates for the sensitive detection of dopamine (DA) molecules in an aqueous solution. The SERS activity of the AgcoreAushell NPs was strongly dependent on the pH of the solution. When the pH of the solution was acidic (pH <5) or basic (pH >9), the AgcoreAushell NPs exhibited negligible SERS activity toward the DA molecules, due to the weakened interactions (or repulsive forces) between the DA molecules and the core–shell NPs. On the other hand, the AgcoreAushell NPs exhibited a high SERS activity in the intermediate pH ranges (pH 7–9), due to the molecular bridging effect of DA molecules, which allows probe molecules to be located at the interstitial junctions (so-called hot spots) between the core–shell NPs. The results of this study highlight the importance of probe-induced clustering of core–shell NPs in the SERS measurements at physiological pH. Keywords: dopamine, AgcoreAushell NPs, solution pH, SERS activityBu YLee SWDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Special Issue on diverse applications in Nano-Theranostics, Pp 47-54 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Bu Y Lee SW The characteristic AgcoreAushell nanoparticles as SERS substrates in detecting dopamine molecules at various pH ranges
description	Yanru Bu,1 Sang-Wha Lee2 1Department of Chemical Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, Australia; 2Department of Chemical and Biochemical Engineering, Gachon University, Seongnam-si, Gyeonggi-do, Republic of Korea Abstract: AgcoreAushell nanoparticles (NPs) are a promising surface-enhanced Raman scattering (SERS) substrate, which can offer a high enhancement factor through the combined effect of the high SERS activity of the Ag core and the biocompatibility of the Au shell. In this study, AgcoreAushell NPs were examined as SERS substrates for the sensitive detection of dopamine (DA) molecules in an aqueous solution. The SERS activity of the AgcoreAushell NPs was strongly dependent on the pH of the solution. When the pH of the solution was acidic (pH <5) or basic (pH >9), the AgcoreAushell NPs exhibited negligible SERS activity toward the DA molecules, due to the weakened interactions (or repulsive forces) between the DA molecules and the core–shell NPs. On the other hand, the AgcoreAushell NPs exhibited a high SERS activity in the intermediate pH ranges (pH 7–9), due to the molecular bridging effect of DA molecules, which allows probe molecules to be located at the interstitial junctions (so-called hot spots) between the core–shell NPs. The results of this study highlight the importance of probe-induced clustering of core–shell NPs in the SERS measurements at physiological pH. Keywords: dopamine, AgcoreAushell NPs, solution pH, SERS activity
format	article
author	Bu Y Lee SW
author_facet	Bu Y Lee SW
author_sort	Bu Y
title	The characteristic AgcoreAushell nanoparticles as SERS substrates in detecting dopamine molecules at various pH ranges
title_short	The characteristic AgcoreAushell nanoparticles as SERS substrates in detecting dopamine molecules at various pH ranges
title_full	The characteristic AgcoreAushell nanoparticles as SERS substrates in detecting dopamine molecules at various pH ranges
title_fullStr	The characteristic AgcoreAushell nanoparticles as SERS substrates in detecting dopamine molecules at various pH ranges
title_full_unstemmed	The characteristic AgcoreAushell nanoparticles as SERS substrates in detecting dopamine molecules at various pH ranges
title_sort	characteristic agcoreaushell nanoparticles as sers substrates in detecting dopamine molecules at various ph ranges
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/403a3b31c73e4a5baa7acc5ce35768c9
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The characteristic AgcoreAushell nanoparticles as SERS substrates in detecting dopamine molecules at various pH ranges

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