MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

Exosomes are involved in the development of metastasis but how their composition is regulated is not well known. Here the authors propose that major vault protein-dependent loading of miR-193a into exosomes could be a general mechanism by which cancer cells get rid of oncosuppressor miRNAs.

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Autores principales:	Yun Teng, Yi Ren, Xin Hu, Jingyao Mu, Abhilash Samykutty, Xiaoying Zhuang, Zhongbin Deng, Anil Kumar, Lifeng Zhang, Michael L. Merchant, Jun Yan, Donald M. Miller, Huang-Ge Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/403d807f4d76457f9f8de1dbcd525283
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spelling	oai:doaj.org-article:403d807f4d76457f9f8de1dbcd5252832021-12-02T17:06:09ZMVP-mediated exosomal sorting of miR-193a promotes colon cancer progression10.1038/ncomms144482041-1723https://doaj.org/article/403d807f4d76457f9f8de1dbcd5252832017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14448https://doaj.org/toc/2041-1723Exosomes are involved in the development of metastasis but how their composition is regulated is not well known. Here the authors propose that major vault protein-dependent loading of miR-193a into exosomes could be a general mechanism by which cancer cells get rid of oncosuppressor miRNAs.Yun TengYi RenXin HuJingyao MuAbhilash SamykuttyXiaoying ZhuangZhongbin DengAnil KumarLifeng ZhangMichael L. MerchantJun YanDonald M. MillerHuang-Ge ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yun Teng Yi Ren Xin Hu Jingyao Mu Abhilash Samykutty Xiaoying Zhuang Zhongbin Deng Anil Kumar Lifeng Zhang Michael L. Merchant Jun Yan Donald M. Miller Huang-Ge Zhang MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression
description	Exosomes are involved in the development of metastasis but how their composition is regulated is not well known. Here the authors propose that major vault protein-dependent loading of miR-193a into exosomes could be a general mechanism by which cancer cells get rid of oncosuppressor miRNAs.
format	article
author	Yun Teng Yi Ren Xin Hu Jingyao Mu Abhilash Samykutty Xiaoying Zhuang Zhongbin Deng Anil Kumar Lifeng Zhang Michael L. Merchant Jun Yan Donald M. Miller Huang-Ge Zhang
author_facet	Yun Teng Yi Ren Xin Hu Jingyao Mu Abhilash Samykutty Xiaoying Zhuang Zhongbin Deng Anil Kumar Lifeng Zhang Michael L. Merchant Jun Yan Donald M. Miller Huang-Ge Zhang
author_sort	Yun Teng
title	MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression
title_short	MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression
title_full	MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression
title_fullStr	MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression
title_full_unstemmed	MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression
title_sort	mvp-mediated exosomal sorting of mir-193a promotes colon cancer progression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/403d807f4d76457f9f8de1dbcd525283
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MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

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