From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release

The purpose of this review is to examine the latest literature on the use of autologous platelet-rich fibrin as a drug and growth factor carrier system in maxillofacial surgery. Autologous platelet-rich fibrin (PRF) is a unique system that combines properties such as biocompatibility and biodegradab...

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Autores principales:	Karina Egle, Ilze Salma, Arita Dubnika
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	platelet-rich fibrin endogenous growth factors carrier systems drug delivery platelet concentrates tissue engineering Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/404040ba592c456790dcea70b912311c
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spelling	oai:doaj.org-article:404040ba592c456790dcea70b912311c2021-11-11T17:01:56ZFrom Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release10.3390/ijms2221115531422-00671661-6596https://doaj.org/article/404040ba592c456790dcea70b912311c2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11553https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The purpose of this review is to examine the latest literature on the use of autologous platelet-rich fibrin as a drug and growth factor carrier system in maxillofacial surgery. Autologous platelet-rich fibrin (PRF) is a unique system that combines properties such as biocompatibility and biodegradability, in addition to containing growth factors and peptides that provide tissue regeneration. This opens up new horizons for the use of all beneficial ingredients in the blood sample for biomedical purposes. By itself, PRF has an unstable effect on osteogenesis: therefore, advanced approaches, including the combination of PRF with materials or drugs, are of great interest in clinics. The main advantage of drug delivery systems is that by controlling drug release, high drug concentrations locally and fewer side effects within other tissue can be achieved. This is especially important in tissues with limited blood supply, such as bone tissue compared to soft tissue. The ability of PRF to degrade naturally is considered an advantage for its use as a “warehouse” of controlled drug release systems. We are focusing on this concentrate, as it is easy to use in manipulations and can be delivered directly to the surgical site. The target audience for this review are researchers and medical doctors who are involved in the development and research of PRFs further studies. Likewise, surgeons who use PRF in their work to treat patients and who advice patients to take the medicine orally.Karina EgleIlze SalmaArita DubnikaMDPI AGarticleplatelet-rich fibrinendogenous growth factorscarrier systemsdrug deliveryplatelet concentratestissue engineeringBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11553, p 11553 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	platelet-rich fibrin endogenous growth factors carrier systems drug delivery platelet concentrates tissue engineering Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	platelet-rich fibrin endogenous growth factors carrier systems drug delivery platelet concentrates tissue engineering Biology (General) QH301-705.5 Chemistry QD1-999 Karina Egle Ilze Salma Arita Dubnika From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release
description	The purpose of this review is to examine the latest literature on the use of autologous platelet-rich fibrin as a drug and growth factor carrier system in maxillofacial surgery. Autologous platelet-rich fibrin (PRF) is a unique system that combines properties such as biocompatibility and biodegradability, in addition to containing growth factors and peptides that provide tissue regeneration. This opens up new horizons for the use of all beneficial ingredients in the blood sample for biomedical purposes. By itself, PRF has an unstable effect on osteogenesis: therefore, advanced approaches, including the combination of PRF with materials or drugs, are of great interest in clinics. The main advantage of drug delivery systems is that by controlling drug release, high drug concentrations locally and fewer side effects within other tissue can be achieved. This is especially important in tissues with limited blood supply, such as bone tissue compared to soft tissue. The ability of PRF to degrade naturally is considered an advantage for its use as a “warehouse” of controlled drug release systems. We are focusing on this concentrate, as it is easy to use in manipulations and can be delivered directly to the surgical site. The target audience for this review are researchers and medical doctors who are involved in the development and research of PRFs further studies. Likewise, surgeons who use PRF in their work to treat patients and who advice patients to take the medicine orally.
format	article
author	Karina Egle Ilze Salma Arita Dubnika
author_facet	Karina Egle Ilze Salma Arita Dubnika
author_sort	Karina Egle
title	From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release
title_short	From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release
title_full	From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release
title_fullStr	From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release
title_full_unstemmed	From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release
title_sort	from blood to regenerative tissue: how autologous platelet-rich fibrin can be combined with other materials to ensure controlled drug and growth factor release
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/404040ba592c456790dcea70b912311c
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From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release

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