A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade

The anti-tumour effect of immune checkpoint inhibitors is potentiated by CD137 agonists in preclinical models, but translation of these results to the clinical practice is hampered by toxicity. Authors describe here a human CD137xPD-L1 bispecific antibody with improved anti-cancer activity whilst ma...

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Autores principales: Cecile Geuijen, Paul Tacken, Liang-Chuan Wang, Rinse Klooster, Pieter Fokko van Loo, Jing Zhou, Arpita Mondal, Yao-bin Liu, Arjen Kramer, Thomas Condamine, Alla Volgina, Linda J. A. Hendriks, Hans van der Maaden, Eric Rovers, Steef Engels, Floris Fransen, Renate den Blanken-Smit, Vanessa Zondag-van der Zande, Abdul Basmeleh, Willem Bartelink, Ashwini Kulkarni, Wilfred Marissen, Cheng-Yen Huang, Leslie Hall, Shane Harvey, Soyeon Kim, Marina Martinez, Shaun O’Brien, Edmund Moon, Steven Albelda, Chrysi Kanellopoulou, Shaun Stewart, Horacio Nastri, Alexander B. H. Bakker, Peggy Scherle, Ton Logtenberg, Gregory Hollis, John de Kruif, Reid Huber, Patrick A. Mayes, Mark Throsby
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4044cbbb9c1d4937ac08f857eba69b30
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spelling oai:doaj.org-article:4044cbbb9c1d4937ac08f857eba69b302021-12-02T16:26:40ZA human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade10.1038/s41467-021-24767-52041-1723https://doaj.org/article/4044cbbb9c1d4937ac08f857eba69b302021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24767-5https://doaj.org/toc/2041-1723The anti-tumour effect of immune checkpoint inhibitors is potentiated by CD137 agonists in preclinical models, but translation of these results to the clinical practice is hampered by toxicity. Authors describe here a human CD137xPD-L1 bispecific antibody with improved anti-cancer activity whilst maintaining low toxicity in non-human primates.Cecile GeuijenPaul TackenLiang-Chuan WangRinse KloosterPieter Fokko van LooJing ZhouArpita MondalYao-bin LiuArjen KramerThomas CondamineAlla VolginaLinda J. A. HendriksHans van der MaadenEric RoversSteef EngelsFloris FransenRenate den Blanken-SmitVanessa Zondag-van der ZandeAbdul BasmelehWillem BartelinkAshwini KulkarniWilfred MarissenCheng-Yen HuangLeslie HallShane HarveySoyeon KimMarina MartinezShaun O’BrienEdmund MoonSteven AlbeldaChrysi KanellopoulouShaun StewartHoracio NastriAlexander B. H. BakkerPeggy ScherleTon LogtenbergGregory HollisJohn de KruifReid HuberPatrick A. MayesMark ThrosbyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Cecile Geuijen
Paul Tacken
Liang-Chuan Wang
Rinse Klooster
Pieter Fokko van Loo
Jing Zhou
Arpita Mondal
Yao-bin Liu
Arjen Kramer
Thomas Condamine
Alla Volgina
Linda J. A. Hendriks
Hans van der Maaden
Eric Rovers
Steef Engels
Floris Fransen
Renate den Blanken-Smit
Vanessa Zondag-van der Zande
Abdul Basmeleh
Willem Bartelink
Ashwini Kulkarni
Wilfred Marissen
Cheng-Yen Huang
Leslie Hall
Shane Harvey
Soyeon Kim
Marina Martinez
Shaun O’Brien
Edmund Moon
Steven Albelda
Chrysi Kanellopoulou
Shaun Stewart
Horacio Nastri
Alexander B. H. Bakker
Peggy Scherle
Ton Logtenberg
Gregory Hollis
John de Kruif
Reid Huber
Patrick A. Mayes
Mark Throsby
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
description The anti-tumour effect of immune checkpoint inhibitors is potentiated by CD137 agonists in preclinical models, but translation of these results to the clinical practice is hampered by toxicity. Authors describe here a human CD137xPD-L1 bispecific antibody with improved anti-cancer activity whilst maintaining low toxicity in non-human primates.
format article
author Cecile Geuijen
Paul Tacken
Liang-Chuan Wang
Rinse Klooster
Pieter Fokko van Loo
Jing Zhou
Arpita Mondal
Yao-bin Liu
Arjen Kramer
Thomas Condamine
Alla Volgina
Linda J. A. Hendriks
Hans van der Maaden
Eric Rovers
Steef Engels
Floris Fransen
Renate den Blanken-Smit
Vanessa Zondag-van der Zande
Abdul Basmeleh
Willem Bartelink
Ashwini Kulkarni
Wilfred Marissen
Cheng-Yen Huang
Leslie Hall
Shane Harvey
Soyeon Kim
Marina Martinez
Shaun O’Brien
Edmund Moon
Steven Albelda
Chrysi Kanellopoulou
Shaun Stewart
Horacio Nastri
Alexander B. H. Bakker
Peggy Scherle
Ton Logtenberg
Gregory Hollis
John de Kruif
Reid Huber
Patrick A. Mayes
Mark Throsby
author_facet Cecile Geuijen
Paul Tacken
Liang-Chuan Wang
Rinse Klooster
Pieter Fokko van Loo
Jing Zhou
Arpita Mondal
Yao-bin Liu
Arjen Kramer
Thomas Condamine
Alla Volgina
Linda J. A. Hendriks
Hans van der Maaden
Eric Rovers
Steef Engels
Floris Fransen
Renate den Blanken-Smit
Vanessa Zondag-van der Zande
Abdul Basmeleh
Willem Bartelink
Ashwini Kulkarni
Wilfred Marissen
Cheng-Yen Huang
Leslie Hall
Shane Harvey
Soyeon Kim
Marina Martinez
Shaun O’Brien
Edmund Moon
Steven Albelda
Chrysi Kanellopoulou
Shaun Stewart
Horacio Nastri
Alexander B. H. Bakker
Peggy Scherle
Ton Logtenberg
Gregory Hollis
John de Kruif
Reid Huber
Patrick A. Mayes
Mark Throsby
author_sort Cecile Geuijen
title A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
title_short A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
title_full A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
title_fullStr A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
title_full_unstemmed A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
title_sort human cd137×pd-l1 bispecific antibody promotes anti-tumor immunity via context-dependent t cell costimulation and checkpoint blockade
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4044cbbb9c1d4937ac08f857eba69b30
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