A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
The anti-tumour effect of immune checkpoint inhibitors is potentiated by CD137 agonists in preclinical models, but translation of these results to the clinical practice is hampered by toxicity. Authors describe here a human CD137xPD-L1 bispecific antibody with improved anti-cancer activity whilst ma...
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Nature Portfolio
2021
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oai:doaj.org-article:4044cbbb9c1d4937ac08f857eba69b302021-12-02T16:26:40ZA human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade10.1038/s41467-021-24767-52041-1723https://doaj.org/article/4044cbbb9c1d4937ac08f857eba69b302021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24767-5https://doaj.org/toc/2041-1723The anti-tumour effect of immune checkpoint inhibitors is potentiated by CD137 agonists in preclinical models, but translation of these results to the clinical practice is hampered by toxicity. Authors describe here a human CD137xPD-L1 bispecific antibody with improved anti-cancer activity whilst maintaining low toxicity in non-human primates.Cecile GeuijenPaul TackenLiang-Chuan WangRinse KloosterPieter Fokko van LooJing ZhouArpita MondalYao-bin LiuArjen KramerThomas CondamineAlla VolginaLinda J. A. HendriksHans van der MaadenEric RoversSteef EngelsFloris FransenRenate den Blanken-SmitVanessa Zondag-van der ZandeAbdul BasmelehWillem BartelinkAshwini KulkarniWilfred MarissenCheng-Yen HuangLeslie HallShane HarveySoyeon KimMarina MartinezShaun O’BrienEdmund MoonSteven AlbeldaChrysi KanellopoulouShaun StewartHoracio NastriAlexander B. H. BakkerPeggy ScherleTon LogtenbergGregory HollisJohn de KruifReid HuberPatrick A. MayesMark ThrosbyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Cecile Geuijen Paul Tacken Liang-Chuan Wang Rinse Klooster Pieter Fokko van Loo Jing Zhou Arpita Mondal Yao-bin Liu Arjen Kramer Thomas Condamine Alla Volgina Linda J. A. Hendriks Hans van der Maaden Eric Rovers Steef Engels Floris Fransen Renate den Blanken-Smit Vanessa Zondag-van der Zande Abdul Basmeleh Willem Bartelink Ashwini Kulkarni Wilfred Marissen Cheng-Yen Huang Leslie Hall Shane Harvey Soyeon Kim Marina Martinez Shaun O’Brien Edmund Moon Steven Albelda Chrysi Kanellopoulou Shaun Stewart Horacio Nastri Alexander B. H. Bakker Peggy Scherle Ton Logtenberg Gregory Hollis John de Kruif Reid Huber Patrick A. Mayes Mark Throsby A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade |
| description |
The anti-tumour effect of immune checkpoint inhibitors is potentiated by CD137 agonists in preclinical models, but translation of these results to the clinical practice is hampered by toxicity. Authors describe here a human CD137xPD-L1 bispecific antibody with improved anti-cancer activity whilst maintaining low toxicity in non-human primates. |
| format |
article |
| author |
Cecile Geuijen Paul Tacken Liang-Chuan Wang Rinse Klooster Pieter Fokko van Loo Jing Zhou Arpita Mondal Yao-bin Liu Arjen Kramer Thomas Condamine Alla Volgina Linda J. A. Hendriks Hans van der Maaden Eric Rovers Steef Engels Floris Fransen Renate den Blanken-Smit Vanessa Zondag-van der Zande Abdul Basmeleh Willem Bartelink Ashwini Kulkarni Wilfred Marissen Cheng-Yen Huang Leslie Hall Shane Harvey Soyeon Kim Marina Martinez Shaun O’Brien Edmund Moon Steven Albelda Chrysi Kanellopoulou Shaun Stewart Horacio Nastri Alexander B. H. Bakker Peggy Scherle Ton Logtenberg Gregory Hollis John de Kruif Reid Huber Patrick A. Mayes Mark Throsby |
| author_facet |
Cecile Geuijen Paul Tacken Liang-Chuan Wang Rinse Klooster Pieter Fokko van Loo Jing Zhou Arpita Mondal Yao-bin Liu Arjen Kramer Thomas Condamine Alla Volgina Linda J. A. Hendriks Hans van der Maaden Eric Rovers Steef Engels Floris Fransen Renate den Blanken-Smit Vanessa Zondag-van der Zande Abdul Basmeleh Willem Bartelink Ashwini Kulkarni Wilfred Marissen Cheng-Yen Huang Leslie Hall Shane Harvey Soyeon Kim Marina Martinez Shaun O’Brien Edmund Moon Steven Albelda Chrysi Kanellopoulou Shaun Stewart Horacio Nastri Alexander B. H. Bakker Peggy Scherle Ton Logtenberg Gregory Hollis John de Kruif Reid Huber Patrick A. Mayes Mark Throsby |
| author_sort |
Cecile Geuijen |
| title |
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade |
| title_short |
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade |
| title_full |
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade |
| title_fullStr |
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade |
| title_full_unstemmed |
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade |
| title_sort |
human cd137×pd-l1 bispecific antibody promotes anti-tumor immunity via context-dependent t cell costimulation and checkpoint blockade |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/4044cbbb9c1d4937ac08f857eba69b30 |
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