A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells

The differentiation of naive T cells to immune suppressing induced regulatory T (iTreg) cells requires TGF-beta-1 and downregulation of mTORC1 activity, which inhibits mRNA translation. Here the authors show that iTreg cell differentiation uses an alternate mRNA translation mechanism involving trans...

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Autores principales:	Viviana Volta, Sandra Pérez-Baos, Columba de la Parra, Olga Katsara, Amanda Ernlund, Sophie Dornbaum, Robert J. Schneider
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4045d5672d59446ca9d6d5c7a59cca09
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spelling	oai:doaj.org-article:4045d5672d59446ca9d6d5c7a59cca092021-12-05T12:21:53ZA DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells10.1038/s41467-021-27087-w2041-1723https://doaj.org/article/4045d5672d59446ca9d6d5c7a59cca092021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27087-whttps://doaj.org/toc/2041-1723The differentiation of naive T cells to immune suppressing induced regulatory T (iTreg) cells requires TGF-beta-1 and downregulation of mTORC1 activity, which inhibits mRNA translation. Here the authors show that iTreg cell differentiation uses an alternate mRNA translation mechanism involving translation factors DAP5 and eIF3d.Viviana VoltaSandra Pérez-BaosColumba de la ParraOlga KatsaraAmanda ErnlundSophie DornbaumRobert J. SchneiderNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Viviana Volta Sandra Pérez-Baos Columba de la Parra Olga Katsara Amanda Ernlund Sophie Dornbaum Robert J. Schneider A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells
description	The differentiation of naive T cells to immune suppressing induced regulatory T (iTreg) cells requires TGF-beta-1 and downregulation of mTORC1 activity, which inhibits mRNA translation. Here the authors show that iTreg cell differentiation uses an alternate mRNA translation mechanism involving translation factors DAP5 and eIF3d.
format	article
author	Viviana Volta Sandra Pérez-Baos Columba de la Parra Olga Katsara Amanda Ernlund Sophie Dornbaum Robert J. Schneider
author_facet	Viviana Volta Sandra Pérez-Baos Columba de la Parra Olga Katsara Amanda Ernlund Sophie Dornbaum Robert J. Schneider
author_sort	Viviana Volta
title	A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells
title_short	A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells
title_full	A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells
title_fullStr	A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells
title_full_unstemmed	A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells
title_sort	dap5/eif3d alternate mrna translation mechanism promotes differentiation and immune suppression by human regulatory t cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4045d5672d59446ca9d6d5c7a59cca09
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A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells

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