Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate

A ten year old mongrel bitch was diagnosed with a primary vulvar transmissible venereal tumor (TVT) causing subcutaneous, mammary and splenic metastasis and it was successfully treated with vincristine. Four months later the animal presented neurological disturbances, brain metastases were suspected...

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Autores principales:	Pedro PINCZOWSKI, Marina GIMENO, Carmen ACEÑA, Ainara VILLEGAS, Alba de MARTINO, Lluís LUJÁN
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2015
Materias:	blood-brain barrier brain metastases dog immunohistochemistry tvt vincristine Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/404ceb83a5c04d9fb06b0144df19b608
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spelling	oai:doaj.org-article:404ceb83a5c04d9fb06b0144df19b6082021-11-17T21:27:50ZBrain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate1820-744810.1515/acve-2015-0011https://doaj.org/article/404ceb83a5c04d9fb06b0144df19b6082015-03-01T00:00:00Zhttps://doi.org/10.1515/acve-2015-0011https://doaj.org/toc/1820-7448A ten year old mongrel bitch was diagnosed with a primary vulvar transmissible venereal tumor (TVT) causing subcutaneous, mammary and splenic metastasis and it was successfully treated with vincristine. Four months later the animal presented neurological disturbances, brain metastases were suspected and the animal was euthanized. A TVT metastatic mass was found in the brain and confirmed with immunohistochemical results, being positive for vimentin and lysozyme and negative for S-100, CD3 and cytokeratin. TVT metastases in the brain are a rare event and cannot be treated with usual chemotherapy as vincristine does not cross the blood-brain barrier, thus allowing the re-emergence of the tumor after a period of time.Pedro PINCZOWSKIMarina GIMENOCarmen ACEÑAAinara VILLEGASAlba de MARTINOLluís LUJÁNSciendoarticleblood-brain barrierbrain metastasesdogimmunohistochemistrytvtvincristineVeterinary medicineSF600-1100ENActa Veterinaria, Vol 65, Iss 1, Pp 137-142 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood-brain barrier brain metastases dog immunohistochemistry tvt vincristine Veterinary medicine SF600-1100
spellingShingle	blood-brain barrier brain metastases dog immunohistochemistry tvt vincristine Veterinary medicine SF600-1100 Pedro PINCZOWSKI Marina GIMENO Carmen ACEÑA Ainara VILLEGAS Alba de MARTINO Lluís LUJÁN Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate
description	A ten year old mongrel bitch was diagnosed with a primary vulvar transmissible venereal tumor (TVT) causing subcutaneous, mammary and splenic metastasis and it was successfully treated with vincristine. Four months later the animal presented neurological disturbances, brain metastases were suspected and the animal was euthanized. A TVT metastatic mass was found in the brain and confirmed with immunohistochemical results, being positive for vimentin and lysozyme and negative for S-100, CD3 and cytokeratin. TVT metastases in the brain are a rare event and cannot be treated with usual chemotherapy as vincristine does not cross the blood-brain barrier, thus allowing the re-emergence of the tumor after a period of time.
format	article
author	Pedro PINCZOWSKI Marina GIMENO Carmen ACEÑA Ainara VILLEGAS Alba de MARTINO Lluís LUJÁN
author_facet	Pedro PINCZOWSKI Marina GIMENO Carmen ACEÑA Ainara VILLEGAS Alba de MARTINO Lluís LUJÁN
author_sort	Pedro PINCZOWSKI
title	Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate
title_short	Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate
title_full	Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate
title_fullStr	Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate
title_full_unstemmed	Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate
title_sort	brain metastasis in a case of canine transmissible venereal tumor after a supposed successful treatment with vincristine sulfate
publisher	Sciendo
publishDate	2015
url	https://doaj.org/article/404ceb83a5c04d9fb06b0144df19b608
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Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate

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