A Combinatorial Approach for the Fabrication of Magneto-Optical Hybrid Nanoparticles

Dmitry S Koktysh,1,2 Wellington Pham3–5 1Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA; 2Vanderbilt Institute for Nanoscale Science and Engineering, Vanderbilt University, Nashville, TN 37235, USA; 3Institute of Imaging Science, Vanderbilt University, Nashville,...

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Autores principales:	Koktysh DS, Pham W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	magnetic nanoparticles quantum dots imaging agents hybrid nanoparticles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/404cfcc4fb7b44608f0b1b18b23192bc
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spelling	oai:doaj.org-article:404cfcc4fb7b44608f0b1b18b23192bc2021-12-02T11:14:46ZA Combinatorial Approach for the Fabrication of Magneto-Optical Hybrid Nanoparticles1178-2013https://doaj.org/article/404cfcc4fb7b44608f0b1b18b23192bc2019-12-01T00:00:00Zhttps://www.dovepress.com/a-combinatorial-approach-for-the-fabrication-of-magneto-optical-hybrid-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Dmitry S Koktysh,1,2 Wellington Pham3–5 1Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA; 2Vanderbilt Institute for Nanoscale Science and Engineering, Vanderbilt University, Nashville, TN 37235, USA; 3Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA; 4Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA; 5Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USACorrespondence: Dmitry S KoktyshDepartment of Chemistry, Vanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University Station B 351822, Nashville, TN 37235-1822, USATel +1615 343-6763Email dmitry.koktysh@vanderbilt.eduWellington PhamInstitute of Imaging Science, Vanderbilt University School of Medicine, 1161, 21st Avenue South, Nashville, TN 37232-2310, USATel +1615 936-7621Email wellington.pham@vumc.orgIntroduction: The increasing demands for better resolution combined with anatomical information in biomedical imaging necessitate the development of multimodal contrast agents. In this respect, the multivalency of nanotechnology enables the integration of nanomaterials with distinct biophysical properties into a unique probe, capable to exert superior imaging characterstics through synergistic enhancement unmatched by any single modality.Materials and methods: Novel magneto-optical hybrid nanoparticles (MOHNPs), comprise semiconductor quantum dots (QDs) tethered on the surface of superparamagnetic iron oxide (SPIO) NPs, were synthesized using a combinatorial approach. The semiconductor components utilized for the synthesis of the hybrid NPs contained cadmium-free QDs, which were stabilized by a variety of functional ligands including thiols, polyethyleneimine (PEI) and amphiphilic polymers. While SPIO NPs were further modified with silica or PEI on the outermost layer. The main mechanism to assemble semiconductor QDs onto the SPIO NPs employed a core-shell approach, in which covalent bonding and electrostatic interaction held the components together.Results: The versatility of the NP assembling mechanism described in this work offered a robust and flexible fabrication of MOHNPs. A proof-of-concept study demonstrated desterous coating of folic acid onto the surface of MOHNPs to create a targeted imaging probe. The emission of the resulted hybrid NPs extended in the near-infrared region, suitable for in vivo applications.Conclusion: This novel assembling technology offers far-reaching capabilities to generate complex multimodal nanoiamging probes.Keywords: magnetic nanoparticles, quantum dots, imaging agents, hybrid nanoparticles  Koktysh DSPham WDove Medical Pressarticlemagnetic nanoparticlesquantum dotsimaging agentshybrid nanoparticlesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 9855-9863 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic nanoparticles quantum dots imaging agents hybrid nanoparticles Medicine (General) R5-920
spellingShingle	magnetic nanoparticles quantum dots imaging agents hybrid nanoparticles Medicine (General) R5-920 Koktysh DS Pham W A Combinatorial Approach for the Fabrication of Magneto-Optical Hybrid Nanoparticles
description	Dmitry S Koktysh,1,2 Wellington Pham3–5 1Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA; 2Vanderbilt Institute for Nanoscale Science and Engineering, Vanderbilt University, Nashville, TN 37235, USA; 3Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA; 4Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA; 5Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USACorrespondence: Dmitry S KoktyshDepartment of Chemistry, Vanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University Station B 351822, Nashville, TN 37235-1822, USATel +1615 343-6763Email dmitry.koktysh@vanderbilt.eduWellington PhamInstitute of Imaging Science, Vanderbilt University School of Medicine, 1161, 21st Avenue South, Nashville, TN 37232-2310, USATel +1615 936-7621Email wellington.pham@vumc.orgIntroduction: The increasing demands for better resolution combined with anatomical information in biomedical imaging necessitate the development of multimodal contrast agents. In this respect, the multivalency of nanotechnology enables the integration of nanomaterials with distinct biophysical properties into a unique probe, capable to exert superior imaging characterstics through synergistic enhancement unmatched by any single modality.Materials and methods: Novel magneto-optical hybrid nanoparticles (MOHNPs), comprise semiconductor quantum dots (QDs) tethered on the surface of superparamagnetic iron oxide (SPIO) NPs, were synthesized using a combinatorial approach. The semiconductor components utilized for the synthesis of the hybrid NPs contained cadmium-free QDs, which were stabilized by a variety of functional ligands including thiols, polyethyleneimine (PEI) and amphiphilic polymers. While SPIO NPs were further modified with silica or PEI on the outermost layer. The main mechanism to assemble semiconductor QDs onto the SPIO NPs employed a core-shell approach, in which covalent bonding and electrostatic interaction held the components together.Results: The versatility of the NP assembling mechanism described in this work offered a robust and flexible fabrication of MOHNPs. A proof-of-concept study demonstrated desterous coating of folic acid onto the surface of MOHNPs to create a targeted imaging probe. The emission of the resulted hybrid NPs extended in the near-infrared region, suitable for in vivo applications.Conclusion: This novel assembling technology offers far-reaching capabilities to generate complex multimodal nanoiamging probes.Keywords: magnetic nanoparticles, quantum dots, imaging agents, hybrid nanoparticles
format	article
author	Koktysh DS Pham W
author_facet	Koktysh DS Pham W
author_sort	Koktysh DS
title	A Combinatorial Approach for the Fabrication of Magneto-Optical Hybrid Nanoparticles
title_short	A Combinatorial Approach for the Fabrication of Magneto-Optical Hybrid Nanoparticles
title_full	A Combinatorial Approach for the Fabrication of Magneto-Optical Hybrid Nanoparticles
title_fullStr	A Combinatorial Approach for the Fabrication of Magneto-Optical Hybrid Nanoparticles
title_full_unstemmed	A Combinatorial Approach for the Fabrication of Magneto-Optical Hybrid Nanoparticles
title_sort	combinatorial approach for the fabrication of magneto-optical hybrid nanoparticles
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/404cfcc4fb7b44608f0b1b18b23192bc
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A Combinatorial Approach for the Fabrication of Magneto-Optical Hybrid Nanoparticles

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