LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames

Blythe et al investigate the patterns of oxidized forms of the 5-methylcytosine DNA modification during spermatogenesis. They find that open reading frames of evolutionarily young and transcriptionally active LINE-1 retrotransposons are enriched in 5-carboxylcytosine (5caC) during spermatid maturati...

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Autores principales:	Martin J. Blythe, Ayhan Kocer, Alejandro Rubio-Roldan, Tom Giles, Abdulkadir Abakir, Côme Ialy-Radio, Lee M. Wheldon, Oxana Bereshchenko, Stefano Bruscoli, Alexander Kondrashov, Joël R. Drevet, Richard D. Emes, Andrew D. Johnson, John R. McCarrey, Daniel Gackowski, Ryszard Olinski, Julie Cocquet, Jose L. Garcia-Perez, Alexey Ruzov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/404f4300a2c74fb1b5b1fc739c852701
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spelling	oai:doaj.org-article:404f4300a2c74fb1b5b1fc739c8527012021-12-02T17:52:31ZLINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames10.1038/s42003-021-02217-82399-3642https://doaj.org/article/404f4300a2c74fb1b5b1fc739c8527012021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02217-8https://doaj.org/toc/2399-3642Blythe et al investigate the patterns of oxidized forms of the 5-methylcytosine DNA modification during spermatogenesis. They find that open reading frames of evolutionarily young and transcriptionally active LINE-1 retrotransposons are enriched in 5-carboxylcytosine (5caC) during spermatid maturation, suggesting a link between 5cac and LINE-1 activity.Martin J. BlytheAyhan KocerAlejandro Rubio-RoldanTom GilesAbdulkadir AbakirCôme Ialy-RadioLee M. WheldonOxana BereshchenkoStefano BruscoliAlexander KondrashovJoël R. DrevetRichard D. EmesAndrew D. JohnsonJohn R. McCarreyDaniel GackowskiRyszard OlinskiJulie CocquetJose L. Garcia-PerezAlexey RuzovNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Martin J. Blythe Ayhan Kocer Alejandro Rubio-Roldan Tom Giles Abdulkadir Abakir Côme Ialy-Radio Lee M. Wheldon Oxana Bereshchenko Stefano Bruscoli Alexander Kondrashov Joël R. Drevet Richard D. Emes Andrew D. Johnson John R. McCarrey Daniel Gackowski Ryszard Olinski Julie Cocquet Jose L. Garcia-Perez Alexey Ruzov LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames
description	Blythe et al investigate the patterns of oxidized forms of the 5-methylcytosine DNA modification during spermatogenesis. They find that open reading frames of evolutionarily young and transcriptionally active LINE-1 retrotransposons are enriched in 5-carboxylcytosine (5caC) during spermatid maturation, suggesting a link between 5cac and LINE-1 activity.
format	article
author	Martin J. Blythe Ayhan Kocer Alejandro Rubio-Roldan Tom Giles Abdulkadir Abakir Côme Ialy-Radio Lee M. Wheldon Oxana Bereshchenko Stefano Bruscoli Alexander Kondrashov Joël R. Drevet Richard D. Emes Andrew D. Johnson John R. McCarrey Daniel Gackowski Ryszard Olinski Julie Cocquet Jose L. Garcia-Perez Alexey Ruzov
author_facet	Martin J. Blythe Ayhan Kocer Alejandro Rubio-Roldan Tom Giles Abdulkadir Abakir Côme Ialy-Radio Lee M. Wheldon Oxana Bereshchenko Stefano Bruscoli Alexander Kondrashov Joël R. Drevet Richard D. Emes Andrew D. Johnson John R. McCarrey Daniel Gackowski Ryszard Olinski Julie Cocquet Jose L. Garcia-Perez Alexey Ruzov
author_sort	Martin J. Blythe
title	LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames
title_short	LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames
title_full	LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames
title_fullStr	LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames
title_full_unstemmed	LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames
title_sort	line-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/404f4300a2c74fb1b5b1fc739c852701
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LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames

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