Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study

Sensitive skin is a prevalent syndrome, characterized by discomfort in response to mild stimuli, which impacts on quality of life. Pruritus is one of the major symptoms of sensitive skin. However, the pathomechanism of sensitive skin is insufficiently understood. As an experimental model for pruritu...

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Autores principales:	Ying Zuo, Ping Jiang, Ruoyu Wan, Li Li, Qiyong Gong, Wei Hua
Formato:	article
Lenguaje:	EN
Publicado:	Society for Publication of Acta Dermato-Venereologica 2021
Materias:	sensitive skin pruritus cowhage Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/4050c78b604047048d8f325422e7fef5
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spelling	oai:doaj.org-article:4050c78b604047048d8f325422e7fef52021-11-10T12:26:27ZCharacterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study10.2340/actadv.v101.4130001-55551651-2057https://doaj.org/article/4050c78b604047048d8f325422e7fef52021-11-01T00:00:00Zhttps://medicaljournalssweden.se/actadv/article/view/413https://doaj.org/toc/0001-5555https://doaj.org/toc/1651-2057Sensitive skin is a prevalent syndrome, characterized by discomfort in response to mild stimuli, which impacts on quality of life. Pruritus is one of the major symptoms of sensitive skin. However, the pathomechanism of sensitive skin is insufficiently understood. As an experimental model for pruritus, the cowhage skin prick test might provide insight into the understanding of sensitive skin. This study aimed to specify the characteristics of cowhage-induced pruritus in sensitive skin. Female volunteers, 20 with sensitive skin and 20 controls, were recruited. Self-report questionnaires were distributed and the responses evaluated; moreover, alongside assessments by dermatologists, skin physiology assessments, lactic acid sting test, capsaicin test and cowhage skin challenge were performed. Pruritus in sensitive skin was perceived as more intense and longer-lasting than in normal skin, with different qualities of accompanying sensations. Cowhage skin challenge results showed moderate consistency with clinical assessments. The results suggest that cowhage skin challenge could be a new tool for the assessment of sensitive skin. Ying ZuoPing JiangRuoyu WanLi LiQiyong GongWei HuaSociety for Publication of Acta Dermato-Venereologicaarticlesensitive skinprurituscowhageDermatologyRL1-803ENActa Dermato-Venereologica, Vol 101, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sensitive skin pruritus cowhage Dermatology RL1-803
spellingShingle	sensitive skin pruritus cowhage Dermatology RL1-803 Ying Zuo Ping Jiang Ruoyu Wan Li Li Qiyong Gong Wei Hua Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study
description	Sensitive skin is a prevalent syndrome, characterized by discomfort in response to mild stimuli, which impacts on quality of life. Pruritus is one of the major symptoms of sensitive skin. However, the pathomechanism of sensitive skin is insufficiently understood. As an experimental model for pruritus, the cowhage skin prick test might provide insight into the understanding of sensitive skin. This study aimed to specify the characteristics of cowhage-induced pruritus in sensitive skin. Female volunteers, 20 with sensitive skin and 20 controls, were recruited. Self-report questionnaires were distributed and the responses evaluated; moreover, alongside assessments by dermatologists, skin physiology assessments, lactic acid sting test, capsaicin test and cowhage skin challenge were performed. Pruritus in sensitive skin was perceived as more intense and longer-lasting than in normal skin, with different qualities of accompanying sensations. Cowhage skin challenge results showed moderate consistency with clinical assessments. The results suggest that cowhage skin challenge could be a new tool for the assessment of sensitive skin.
format	article
author	Ying Zuo Ping Jiang Ruoyu Wan Li Li Qiyong Gong Wei Hua
author_facet	Ying Zuo Ping Jiang Ruoyu Wan Li Li Qiyong Gong Wei Hua
author_sort	Ying Zuo
title	Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study
title_short	Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study
title_full	Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study
title_fullStr	Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study
title_full_unstemmed	Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study
title_sort	characterization of cowhage-induced pruritus in sensitive skin: an observational laboratory study
publisher	Society for Publication of Acta Dermato-Venereologica
publishDate	2021
url	https://doaj.org/article/4050c78b604047048d8f325422e7fef5
work_keys_str_mv	AT yingzuo characterizationofcowhageinducedpruritusinsensitiveskinanobservationallaboratorystudy AT pingjiang characterizationofcowhageinducedpruritusinsensitiveskinanobservationallaboratorystudy AT ruoyuwan characterizationofcowhageinducedpruritusinsensitiveskinanobservationallaboratorystudy AT lili characterizationofcowhageinducedpruritusinsensitiveskinanobservationallaboratorystudy AT qiyonggong characterizationofcowhageinducedpruritusinsensitiveskinanobservationallaboratorystudy AT weihua characterizationofcowhageinducedpruritusinsensitiveskinanobservationallaboratorystudy
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Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study

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